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Could a Heart-Lung machine at the scene of a cardiac arrest double survival?

NCT ID NCT07679737

Disease control Sponsor: Australian and New Zealand Intensive Care Research Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study looks at whether giving people a heart-lung machine (ECPR) right where they collapse from a cardiac arrest can help more of them survive to leave the hospital. Researchers will compare people who get this extra treatment with those who get standard CPR and care. The study includes adults who had a witnessed cardiac arrest, got bystander CPR, and did not recover quickly with standard efforts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Extracorporeal cardiopulmonary resuscitation (ECPR)
What this could lead to
If it works, this could point toward a way to save more people who suffer a cardiac arrest outside a hospital.
What could go wrong
This is an observational study, not a randomized trial, so results may be less reliable. ECPR carries risks like bleeding or infection, and it may not improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with refractory out-of-hospital cardiac arrest in the metropolitan regions of Sydney and Melbourne.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Witnessed cardiac arrest * Bystander CPR * Refractory cardiac arrest (failure to achieve sustained ROSC \>20 minutes) * Initial cardiac rhythm VF, VT or PEA * Within the hours of prehospital ECPR service operation Exclusion Criteria: * Initial cardiac rhythm asystole * ROSC with sustained recovery * Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest * Evidence of/suspected end-stage disease: * severe disability impairing activities of daily living * end-stage organ disease - cardiac, liver, lung, renal * other life-limiting diseases, e.g. malignancy, terminal illness * advance health care directive * Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extracorporeal cardiopulmonary resuscitation Out-of-hospital cardiac arrest

Contacts and locations

Locations

  • Monash University

    Melbourne, Victoria, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.