OUT-OF-HOSPITAL CARDIAC ARREST

This study tests if using two defibrillator pads in different positions and giving two quick shocks instead of one can help more people survive a cardiac arrest. It includes 916 adults whose heart stopped outside a hospital and did not respond to the first standard shock. The goa…

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) to adults who suffer a sudden cardiac arrest outside the hospital can restart their heart better than the standard single drug (epinephrine). About 1,344 participants will be ra…

This study tests a simple procedure called remote ischemic post-conditioning (RIPOST) in 48 adults who suffered a cardiac arrest outside the hospital. RIPOST involves briefly inflating and deflating a blood pressure cuff on the leg to protect the brain from damage caused by blood…

This study tests whether cooling the brain immediately after a cardiac arrest, using a special nasal device, helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randomly assigned to either receive this ultra-…

This study observes 300 adults who survived a cardiac arrest outside the hospital and are now in the intensive care unit. Researchers will measure how much pain patients experience using special pain scales, even if they are unconscious or on a breathing machine. The goal is to u…

This study looks at whether a simpler form of CPR—using only chest compressions—works as well as standard CPR (compressions plus rescue breaths) for people who collapse from cardiac arrest outside a hospital. About 3,260 adults with witnessed cardiac arrest will be included, and …

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside the hospital due to a heart problem. The goal is to track their treatment and recovery to find ways to improve survival and quality of life. No new treatments are bein…

This study tests whether cooling cardiac arrest patients right after their heartbeat returns, using a special vest in the ambulance, is practical and safe. About 50 adults who remain unconscious after cardiac arrest will be cooled by paramedics before reaching the hospital. The g…

This study looks at 840 adults in Paris whose hearts stopped and did not restart with standard CPR. They received a special machine called ECMO that pumps blood for the body while doctors try to restart the heart. The goal is to see how many people survive for one year and how we…

This study looks at whether using a balloon to block the aorta (a major blood vessel) during a heart attack outside the hospital can help blood flow to the heart and brain. It involves 40 adults who are in cardiac arrest and receiving standard emergency care. The goal is to see i…

This study explores using drones to bring automated external defibrillators (AEDs) to people helping someone having a cardiac arrest outside a hospital. Researchers will test the delivery process with training manikins and interview people with and without cardiac arrest experien…

This study creates a training program using simulation and artificial intelligence to teach doctors how to perform heart ultrasound (TEE) during cardiac arrest. About 60 junior emergency physicians will take the course and be tested on their skills. The goal is to see if the AI c…

This study looks at 3500 adults who survived a cardiac arrest outside the hospital and are now in intensive care. Researchers want to see how different treatments—like sedation, body temperature control, and blood pressure management—affect kidney health. The goal is to find bett…

This study aims to see if giving community first responders real-time video support from emergency dispatchers can improve the quality of CPR they provide. About 165 trained volunteers in Singapore will be randomly assigned to use either the current system or an enhanced version …

This study looks at rules used by emergency workers to decide when to stop trying to restart a person's heart after a cardiac arrest outside a hospital. These rules were made in Western countries, and researchers want to see if they work well for people in Asia. They will study 1…