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Could a Three-Drug cocktail save more cardiac arrest patients?

NCT ID NCT06203847

Disease control Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a combination of three drugs (epinephrine, vasopressin, and a steroid) during emergency treatment for out-of-hospital cardiac arrest can restart the heart and improve survival compared to the standard drug epinephrine alone. About 1,344 adults in Taipei who suffer sudden cardiac arrest will be randomly assigned to receive either the drug combo or standard care. The main goal is to see if the combo leads to a sustained return of spontaneous circulation for at least 2 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
epinephrine, vasopressin, and methylprednisolone
What this could lead to
If it works, this could point toward a more effective emergency treatment for cardiac arrest, potentially saving more lives and improving recovery.
What could go wrong
This is an early-stage trial with 1,344 participants, and the drug combo may not improve outcomes or could have side effects. Results may not apply to all cardiac arrest cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,344 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (aged \>= 18 ) * Out-of-hospital cardiac arrest in the studied regions * Treated by paramedics authorized and capable of giving prehospital medication Exclusion Criteria: * OHCA with traumatic etiology * Obvious signs of death like decapitation, rigor mortis, livor mortis, decomposition, etc. * DNR (Do Not Resuscitation) or termination of resuscitation requested by the family * Patients with known or suspected pregnancy * No vascular access was established before hospital arrival * ROSC before the administrated medication * No patient contact (cancelled ambulance call or the patient was transported to the hospital before the arrival of trial-trained paramedics) * Received epinephrine prior to the arrival of trial-trained paramedics

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Conditions

The condition(s) this trial relates to.

cardiac arrest diabetes insipidus Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest Emergency medical services Out-of-hospital cardiac arrest

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 100, Taiwan

More trials for these conditions

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