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Heart attack survivors' kidneys under microscope in massive study

NCT ID NCT07579390

Knowledge-focused Sponsor: Helsinki University Central Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examines how different hospital treatments—sedation, temperature control, and blood pressure management—after a cardiac arrest impact kidney function. Researchers will follow 3500 adults who were resuscitated from a heart attack outside the hospital. The goal is to understand which approaches lead to fewer kidney complications, not to test a new drug or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 3,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All patients included to the main STEPCARE-trial are also included to this substudy * Out-of-hospital cardiac arrest * Sustained return of spontaneous circulation, defined as 20 minutes with signs of circulation without the need for chest compressions * Unconsciousness (FOUR-score motor response \<4, inability to obey verbal commands), or being intubated and sedated due to agitation * Eligible for intensive care without restrictions or limitations * Inclusion within 4 hours of the return of spontaneous circulation Exclusion Criteria: * Out-of-hospital cardiac arrest of presumed traumatic or hemorrhagic origin * Confirmed or suspected intracranial hemorrhage * Pregnancy * Extracorporeal membrane oxygenation (ECMO) prior to randomization * No additional exclusion criteria are applied beyond those of the main STEPCARE trial

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Conditions

The condition(s) this trial relates to.

acute kidney injury cardiac arrest Fever hypertensive disorder Out-of-Hospital Cardiac Arrest sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney failure Blood pressure Cardiac arrest (CA) Fever Mean arterial pressure targets Out-of-hospital cardiac arrest Renal replacement therapy for acute kidney injury in icu Resuscitated sudden cardiac death Sedation in intensive care Sedation in intensive care unit patients Sedation in the icu Temperature

Contacts and locations

Locations

  • Austin Hospital

    Melbourne, Australia

  • Bern University Hospital

    Bern, Switzerland

  • Bristol Royal Infirmary

    Bristol, United Kingdom

  • Cardiff University Hospital

    Cardiff, United Kingdom

  • Centre Hospitalier de Luxembourg

    Luxembourg, Luxembourg

  • Charite University Hospital

    Berlin, Germany

  • Christchurch Hospital

    Christchurch, New Zealand

  • DCCM ICU

    Auckland, New Zealand

  • Essex Cardiothoracic Centre

    Basildon, United Kingdom

  • Ghent University Hospital

    Ghent, Belgium

  • HUB Hôpital Erasme

    Brussels, Belgium

  • Hallands hospital

    Halmstad, Sweden

  • Helsingborg Hospital

    Helsingborg, Sweden

  • Jorvi Hospital

    Espoo, Finland

  • Jyväskylä Hospital

    Jyväskylä, Finland

  • Kalnes Hospital

    Grålum, Norway

  • Karlstad hospital

    Karlstad, Sweden

  • Karolinska University Hospital

    Stockholm, Sweden

  • King Abdulaziz Medical City

    Riyadh, Saudi Arabia

  • Kings College Hospita

    London, United Kingdom

  • Kuopio University Hospital

    Kuopio, Finland

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Liverpool Hospital

    Liverpool, Australia

  • Lübeck University Hospital

    Lübeck, Germany

  • Meilahti Hospital

    Helsinki, 00290, Finland

  • Middlemore ICU

    Auckland, New Zealand

  • Nepean Hospital

    Kingswood, Australia

  • North Estonia Medical Centre

    Tallinn, Estonia

  • North Shore ICU NZ

    Auckland, New Zealand

  • Oslo University Hospital

    Oslo, Norway

  • Oulu University Hospital

    Oulu, Finland

  • Princess Alexandra Hospital

    Brisbane, Australia

  • Royal North Shore Hospital

    Sydney, Australia

  • Sahlgrenska University Hospital

    Gothenburg, Sweden

  • San Martino Hospital Genova

    Genova, Italy

  • Skaraborg Hospital Skovde

    Skövde, Sweden

  • Skåne University Hospital

    Lund, Sweden

  • Skåne University Hospital Malmö

    Malmö, Sweden

  • Soerlandet Hospital Arendal

    Arendal, Norway

  • St Bartholomew's Hospital

    London, United Kingdom

  • St Gallen Hospital

    Sankt Gallen, Switzerland

  • St George Hospital

    Sydney, Australia

  • St Georges University Hospital

    London, United Kingdom

  • Stavanger University Hospital

    Stavanger, Norway

  • Tan Tock Seng Hospital

    Singapore, Singapore

  • The Prince Charles Hospital

    Brisbane, Australia

  • The Sutherland Hospital

    Sydney, Australia

  • Tubingen University Hospital

    Tübingen, Germany

  • University Hospital Zürich

    Zurich, Switzerland

  • University Hospital of Umeå

    Umeå, Sweden

  • Wellington Hospital

    Wellington, New Zealand

  • Ziekenhuis Oost-Limburg Hospital

    Lanaken, Belgium

More trials for these conditions

Other studies related to the condition(s) this trial covers.