CARDIAC ARREST (CA)

This study tests whether giving a special life-support machine (ECMO) at the scene of a cardiac arrest helps more people survive than waiting until they reach the hospital. About 90 adults under 70 who have a witnessed heart attack and receive bystander CPR will be included. The …

This study tests a new balloon device, called NEURESCUE, that is placed in a leg artery and inflated to redirect blood to the heart and brain during cardiac arrest. The goal is to see if using this device along with standard CPR and life support helps more people regain a heartbe…

This study tests a special breathing method (called the OPTI-VENT bundle) for children whose hearts stop beating in the hospital. The goal is to see if this method helps more children survive and have better brain function compared to standard care. About 1,530 children receiving…

This study tests whether adding a small amount of air pressure (called PEEP) to the breathing tube during CPR helps restart the heart and improves survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive either standard …

This study tests a new CT scan method to check for blocked heart arteries in people who survive a cardiac arrest. The scan uses existing images and special software, so no extra medication or monitoring is needed. Researchers will compare the CT results with standard angiography …

This study tests two resilience-building programs for cardiac arrest survivors and their caregivers. The goal is to reduce anxiety, depression, and emotional distress while improving quality of life. About 84 pairs (survivor plus caregiver) will participate in a series of session…

This study tests a new type of talk therapy called AMBET for people who have PTSD after surviving a cardiac arrest. About 90 adults will be randomly assigned to either AMBET or another therapy (PCT) for 12 weeks. Researchers will track PTSD symptoms, mood, sleep, and activity to …

This study looks at 50 adults who had a cardiac arrest to see if new blood tests and brain ultrasounds can better predict how well their brain will recover. Current methods are limited, so doctors hope these tools will help them make more informed decisions about care. The goal i…

This study tests whether artificial intelligence can help emergency call operators quickly identify serious conditions like heart attack, stroke, or breathing trouble. Researchers will analyze millions of past emergency calls to build and compare AI models. The goal is to reduce …

This study looks at the spinal fluid of 60 people who had a cardiac arrest to find out what causes brain damage afterward. Researchers will use advanced lab tests to spot changes in genes, proteins, and other molecules. The goal is to identify new drug targets and design future t…

This study looks at data from 150 people who had a cardiac arrest outside the hospital and received CPR. Researchers want to measure how often the airway closes during chest compressions, which can make breathing support less effective. They hope to find a link between airway ope…

This study tests whether improved phone instructions for CPR, which also guide the use of an AED, can reduce time without chest compressions during a cardiac arrest. About 80 volunteers (healthcare workers and laypeople) will perform CPR in a simulated emergency, following either…

This study looks at how to reduce major complications and improve survival for people on ECMO, a machine that helps the heart and lungs when they fail. Researchers will compare different treatments in 600 adults to see which ones lead to better outcomes, like needing less organ s…

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18-50. Researchers will analyze blood samples from 1,725 patients in Lombardy, Italy, and check their family members for inherited heart disease risks. The goal is to better understand these g…

This study watches 250 adults who are unconscious after a cardiac arrest to find early signs that predict when they will wake up. Researchers use brain wave tests, eye exams, and ultrasound to gather clues. The goal is to help doctors better understand recovery, not to test a new…

This study looks at 3500 adults who survived a cardiac arrest outside the hospital and are now in intensive care. Researchers want to see how different treatments—like sedation, body temperature control, and blood pressure management—affect kidney health. The goal is to find bett…

This study watches how breathing support (ventilation) is given during CPR to adults whose hearts stop in the hospital. Researchers want to find which breathing rate and volume gives the best chance of restarting the heart. The study will track 900 patients and compare different …

This study looks for brain injury in patients who had a cardiac arrest, using a portable MRI machine that can be used at the bedside. Researchers will take multiple scans over several days to see how the injury changes. The goal is to make brain imaging available at hospitals wit…

This study compares a new mixed reality (MR) system for learning CPR to standard instructor-led training. Researchers want to see if the MR method is just as effective at teaching CPR skills. The study will involve 120 adults aged 18-50 who haven't had CPR training in the last ye…

This study follows 12 cardiac arrest survivors for 5 years to see how they are doing after receiving ultra-rapid cooling treatment. The cooling was done using a special system that lowers body temperature quickly to protect the brain and heart. Researchers will check if participa…

This study will follow 10,000 people with heart conditions (like heart failure, heart attack, or bypass surgery) who are going through cardiac rehab at a clinic in Davos, Switzerland. Researchers will collect health data, blood samples, and patient reports to learn what helps peo…

This study looks at whether long-term stress plays a role in cardiac arrest. Researchers will measure the stress hormone cortisol in hair samples from 136 people who survived a cardiac arrest or heart attack. The goal is to see if higher stress levels are linked to worse outcomes…