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Could a tiny valve boost survival after cardiac arrest?

NCT ID NCT06939335

Disease control Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a small valve (PEEP) to the breathing bag during CPR helps restart the heart and improve survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive CPR with or without PEEP. The goal is to see if this simple change leads to better outcomes, including survival with good brain function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Positive End-Expiratory Pressure (PEEP) via a disposable valve set at 5 cm H2O
What this could lead to
If it works, this could improve survival and brain function after cardiac arrest by keeping airways open during CPR.
What could go wrong
This is a small, early-phase trial (132 participants), so results may not apply broadly. PEEP may also increase chest pressure or cause lung injury.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 132 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age: Adults aged 18 years and older. 2. Type of Cardiac Arrest: Patients who have experienced a non-traumatic out-of-hospital cardiac arrest. 3. CPR Administration: Patients receiving cardiopulmonary resuscitation from an advanced life support (ALS) team. 4. Intubation and Ventilation: Patients who are intubated and ventilated during resuscitation efforts. Exclusion Criteria: 1. Cardiac arrest in patient younger than 18 years of age. 2. Traumatic cardiac arrest, including drowning, penetrating or blunt injury, and burns. 3. Immediate Return of Spontaneous Circulation (ROSC): Patients who achieve ROSC before intubation and initiation of intubation. 4. Pregnancy. 5. Mechanical ventilation during arrest: patients already receiving mechanical ventilation at the moment of cardiac arrest, due to reasons other than their arrest, will be excluded. 6. Do Not Resuscitate (DNR) Orders: Patients with existing DNR orders or any advanced directive indicating that CPR should not be performed. 7. Failure to intubate: if intubation is unsuccessful, ventilation by any means (MBV, SGA) should take priority over the study protocol, and the patient is excluded. 8. Enrolment in Other Studies: Patients currently enrolled in another interventional clinical trial that could interfere with the outcomes of this study.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest (CA) Out-of-hospital cardiac arrest (OHCA) Positive end-expiratory pressure (PEEP) Ventilation during resuscitation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    6 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AZ Oostende

    RECRUITING

    Ostend, West-Flandres, 8400, Belgium

  • AZ Zeno

    RECRUITING

    Knokke, 8300, Belgium

    Contact Email: •••••@•••••

  • AZORG: Campus Moorselbaan

    RECRUITING

    Aalst, B-9300, Belgium

  • AZORG: campus Geraardsbergen

    RECRUITING

    Geraardsbergen, B-9500, Belgium

  • AZORG: campus Merestraat

    RECRUITING

    Aalst, B-9300, Belgium

  • Centre hospitalier universitaire (CHU) Besançon-Franche-Comté

    ACTIVE_NOT_RECRUITING

    Besançon, France

  • UZ Ghent

    RECRUITING

    Ghent, B-9240, Belgium

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