New CT technique could spare some cardiac arrest patients from invasive heart tests
NCT ID NCT07388342
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results will be compared to the standard invasive angiography. If the CT is accurate, it could help doctors decide who truly needs urgent angiography and who can safely wait.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 30 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* Inclusion: * Adults (≥18 years) with sustained return of spontaneous circulation (ROSC) following in/out-of-hospital cardiac arrest. * Informed consent from patient or representative obtained before invasive coronary angiography. * Exclusion * Patients on VA-ECMO * ACS STEMI or STEMI "equivalent" * New left/right bundle branch block * ST segment depression in leads V1-V3, when the terminal T wave is positive and concomitant ST-segment elevation ≥ 0,5mm recorded in leads V7-V9 (posterior MI) * ST-segment elevation in V7-V9 (posterior MI) or V3R-V4R (RV MI) * ACS NSTEMI with persistent ST depression despite optimal therapy, suggesting ongoing myocardial ischemia, with indication for an urgent ICA according to the treating physician. * Hemodynamic/electrical instability precluding CT imaging (as perceived by the treating physician) * Life-threatening arrhythmia potentially caused by acute myocardial ischemia * Absolute contraindications to iodinated contrast * Patients with a known non-cardiac cause of cardiac arrest (e.g., traumatic brain injury, overt hemorrhage, asphyxia/severe hypoxia due to known lung disease, trauma, severe metabolic/electrolyte derangement, or intoxication) as perceived by the treating physician, where chest CT is considered unnecessary. * Known or likely pregnancy or lactation * Severe bleeding issue (as perceived by the treating physician) precluding heparin administration during radial access coronary angiography. * Prior coronary intervention (stent implantation/CABG). * CT findings indicating a condition that precludes coronary angiography in the short term. * Patients with end-of-life care pathways. * Participation in another intervention study interfering with the research questions in OPEN CCT Arrest.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Universitair Ziekenhuis Brussel (UZB)
RECRUITINGBrussels, Vlaams Brabant, 1090, Belgium
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