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6,464 patients join global hunt for bicuspid valve genes

NCT ID NCT01980797

Knowledge-focused Sponsor: Boston University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study gathers genetic and health information from over 6,400 people with bicuspid aortic valve, a common heart defect. Researchers aim to find the genes responsible for the condition and why some patients later develop serious aortic disease. No treatment is given; the goal is to better understand and predict the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

6,464 people

The number who actually took part.

Started

Nov 2013

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with and without bicuspid aortic valves disease

Ages

8 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed as having a bicuspid aortic valve * All ages ≥8 years * Able to provide fully informed consent Exclusion Criteria: * None

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Conditions

The condition(s) this trial relates to.

Bicuspid Aortic Valve Disease familial bicuspid aortic valve

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bicuspid aortic valve disease Thoracic aortic disease in patients with A bicuspid aortic valve

Contacts and locations

Locations

  • Boston Medical Center

    Boston, Massachusetts, 02218, United States

  • Hospital Vall d'Hebron

    Barcelona, 08035, Spain

  • Istituto Policlinico San Donato

    San Donato Milanese, Milan, 20097, Italy

  • Laval University

    Québec, Quebec, G1V 4G5, Canada

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Monaldi Hospital

    Naples, 80100, Italy

  • Second University of Naples

    Naples, 80131, Italy

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Oxford

    Oxford, OX3 9DU, United Kingdom

  • University of Salerno

    Salerno, 36-83023, Italy

  • University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.