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Blood pressure clues may predict early death after heart attack

NCT ID NCT07586878

Knowledge-focused Sponsor: Region Skane Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study examines whether a low pulse pressure (the difference between top and bottom blood pressure numbers) in the first hours after a cardiac arrest is linked to early death. Researchers will analyze data from 3500 patients who had a cardiac arrest outside the hospital and are already part of a larger trial. The goal is to better understand which patients are at highest risk, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify high-risk patients sooner after cardiac arrest, potentially guiding better care.
What could go wrong
This is an observational study, not a treatment trial. It only looks for associations, not cause and effect, so findings may not change practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

3,500 people

The number who actually took part.

Started

Aug 2023

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Randomized STEPCARE participants with available trial data for STEP-PRESS analyses. The STEP-PRESS source population consists of randomized STEPCARE participants excluding consent withdrawals. The primary analysis population is restricted to participants alive 12 hours after randomization, without mechanical circulatory support initiated before or within 24 hours after randomization, and with sufficient valid blood-pressure observations during 0 to 12 hours after randomization.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Randomized in the STEPCARE trial. * Out-of-hospital cardiac arrest. * Stable return of spontaneous circulation, defined in the parent STEPCARE protocol as at least 20 minutes without chest compressions. * Unconsciousness after sustained return of spontaneous circulation, defined as not being able to obey verbal commands, or intubated and sedated because of agitation. * Eligible for intensive care without restrictions or limitations. * Included in STEPCARE within the parent-trial inclusion window. * For STEP-PRESS analyses, availability of recorded STEPCARE blood-pressure data sufficient to calculate pulse pressure for the relevant analysis population. * For the primary STEP-PRESS analysis population: alive 12 hours after randomization, without mechanical circulatory support initiated before or within 24 hours after randomization, and with at least three valid recorded blood-pressure observations during 0 to 12 hours after randomization. Exclusion Criteria: * Withdrawal of consent for use of STEPCARE trial data. * Trauma or hemorrhage as the presumed cause of cardiac arrest. * Suspected or confirmed intracranial hemorrhage. * On extracorporeal membrane oxygenation before STEPCARE randomization. * Pregnancy. * Previously randomized in the STEPCARE trial. * For STEP-PRESS primary and 24-hour landmark analyses: mechanical circulatory support initiated before or within 24 hours after randomization. * For endpoint-specific analyses: missing data required to define the relevant exposure, outcome, or biomarker endpoint.

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Conditions

The condition(s) this trial relates to.

cardiac arrest Charcot-Marie-Tooth disease type 1F Out-of-Hospital Cardiac Arrest post-cardiac arrest syndrome sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Out-of-hospital cardiac arrest (OHCA) Post-cardiac arrest syndrome

Contacts and locations

Locations

  • Department of Intensive Care, Skåne University Hospital

    Malmö, 20205, Sweden

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