New study tests repatha® combo to slash heart risks in 7,000 chinese patients
NCT ID NCT06295679
First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 1 time
Summary
This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are either prescribed Repatha® plus standard care or standard care alone, based on their doctor's decision. The goal is to learn how well this combination works in everyday practice.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Repatha® (evolocumab), a cholesterol-lowering injection
- What this could lead to
- If it works, this could show that adding Repatha® to usual care significantly lowers the risk of major heart problems like heart attacks and strokes in Chinese patients.
- What could go wrong
- This is an observational study, not a controlled trial, so results may be less reliable. The study is still recruiting and outcomes won't be known for years.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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7,000 people
The number who actually took part.
- Started
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Dec 2022
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population comprises Chinese participants with established ASCVD treated with Repatha® in combination with SOC or with SOC alone in a clinical setting which includes any primary through tertiary healthcare setting where Repatha® is prescribed.
- Ages
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18 to 150 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult participants ≥ 18 years of age. * Participants or participant's legally authorized representative has provided informed consent to participate in this study. * Participants who meet one of the following: * Prescribed Repatha® in addition to an existing SOC treatment according to local guidelines and approved label. OR * Already received SOC treatment prior to enrollment. * Participants with ANY of the following. * Diagnosis of MI OR stroke within 2 years before enrollment. * 2 MIs OR ≥ 2 strokes OR (≥ 1 MI AND ≥ 1 stroke) any time before enrollment. * Diagnosis of (MI OR stroke) AND diabetes. * Diagnosis of (MI OR stroke) AND documented multivessel disease (defined as \> 50% stenosis of ≥ 2 major coronary arteries on coronary angiography or coronary artery contrast enhanced computed tomography). * Diagnosis of symptomatic peripheral arterial disease. * Most recent fasting LDL-C ≥ 70 mg/dL (≥ 1.8 mmol/L) or nonhigh-density lipoprotein cholesterol (non-HDL-C) ≥ 100 mg/dL (≥ 2.6 mmol/L) within 6 months prior to enrollment. * Most recent fasting triglycerides ≤ 400 mg/dL (≤ 4.5 mmol/L) within 6 months prior to enrollment. Exclusion Criteria: * Stroke within past 1 month. * Known hemorrhagic stroke at any time. * Stroke due to thromboembolic event. * Any prior use of Repatha® or other proprotein convertase subtilisin/kexin type 9 inhibition treatments within past 6 months prior to enrollment. * Participants currently enrolled in another study involving any investigational procedure, device or drug. * Participants prescribed Repatha® with a history of severe hypersensitivity or allergy to any subsidiary.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Affiliated hospital of Jining Medical University
Jining, Shandong, 272009, China
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Beijing Anzhen Hospital, Capital Medical University
Beijing, Beijing Municipality, 100029, China
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Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, 100050, China
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Beijing Haidian Hospital
Beijing, Beijing Municipality, 100086, China
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Beijing Hospital
Beijing, Beijing Municipality, 100730, China
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Cangzhou Central Hospital
Cangzhou, Hebei, 061001, China
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Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Dalian, Liaoning, 116000, China
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Changshu No1 Peoples Hospital
Changshu, Jiangsu, 215500, China
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Changshu No2 Peoples Hospital
Changshu, Jiangsu, 215523, China
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Chengdu First Peoples Hospital
Chengdu, Sichuan, 610041, China
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Chengdu Third Peoples Hospital
Chengdu, Sichuan, 61031, China
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China Japan Friendship Hospital
Beijing, Beijing Municipality, 100029, China
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Chongqing Emergency Medical Center
Chongqing, Chongqing Municipality, 400014, China
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Chongqing General Hospital
Chongqing, Chongqing Municipality, 401121, China
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Dongguan Songshan Lake Central Hospital
Dongguan, Guangdong, 523127, China
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First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, 650032, China
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First Hospital of Shanxi Medical University
Taiyuan, Shanxi, 030000, China
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Fuwai Central China Cardiovascular Hospital
Zhengzhou, Henan, 450018, China
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Fuwai Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100037, China
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General Hospital of Northern Theater Command
Shenyang, Liaoning, 110016, China
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Heilongjiang Provincial Hospital
Haerbin, Heilongjiang, 150036, China
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Huaihe Hospital of Henan University
Kaifeng, Henan, 475000, China
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Hunan Provincial Peoples Hospital
Changsha, Hunan, 410005, China
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Huzhou Central Hospital
Huzhou, Zhejiang, 310005, China
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Jiangxi Provincial Peoples Hospital
Nanchang, Jiangxi, 330006, China
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Jiaxing Second Hospital
Jiaxing, Zhejiang, 314000, China
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Jinan Central Hospital
Jinan, Shandong, 250013, China
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Nanfang Hospital Southern Medical University
Guangzhou, Guangdong, 510515, China
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Nantong First Peoples Hospital
Nantong, Jiangsu, 226000, China
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Nanyang Central Hospital
Nanyang, Henan, 473000, China
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Ningbo Medical Center Lihuili Hospital
Ningbo, Zhejiang, 315046, China
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Peking University First Hospital
Beijing, Beijing Municipality, 100034, China
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Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
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Provincial Hospital Affiliated to Shandong First Medical University
Jinan, Shandong, 250021, China
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Qilu Hospital of Shandong University
Jinan, Shandong, 250012, China
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Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi, 710068, China
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Shaoxing Second Hospital
Shaoxing, Zhejiang, 312000, China
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Sichuan Academy of Medical Sciences Sichuan Provincial Peoples Hospital
Chengdu, Sichuan, 610031, China
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Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Hangzhou, Zhejiang, 310016, China
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Tangdu Hospital of Air Force Medical University
Xi'an, Shaanxi, 710038, China
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Tangshan Gongren Hospital
Tangshan, Hebei, 63000, China
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The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, 550001, China
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The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, 221006, China
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The Central Hospital of Wuhan
Wuhan, Hubei, 430014, China
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The First Affiliated Hospital Sun-Yat Sen University
Guangzhou, Guangdong, 510080, China
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The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, 116000, China
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The First Affiliated Hospital of Jinan University
Guangzhou, Guangdong, 510630, China
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The First Affiliated Hospital of Jinzhou Medical University
Jinzhou, Liaoning, 121000, China
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The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, 330006, China
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The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, 315010, China
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The First Affiliated Hospital of Shandong First Medical University
Jinan, Shandong, 250014, China
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The First Affiliated Hospital of Shantou University Medical College
Guangzhou, Guangdong, 510280, China
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The First Affiliated Hospital of Xi An Jiaotong University
Xi’an, Shanxi, 710061, China
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The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, 830054, China
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The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, 450052, China
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The First Hospital of Nanchang
Nanchang, Jiangxi, 330008, China
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The First Peoples Hospital of Foshan
Foshan, Guangdong, 528000, China
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The First Peoples Hospital of Huzhou
Huzhou, Zhejiang, 313000, China
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The First Peoples Hospital of Kunshan
Suzhou, Jiangsu, 215300, China
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The First Peoples Hospital of Yulin
Yulin, Guangxi, 537006, China
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The First Peoples Hospital of Yunnan Province
Kunming, Yunnan, 650032, China
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The Fourth Affiliated Hospital of China Medical University
Shenyang, Liaoning, 110032, China
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The Fourth Hospital of Harbin Medical University
Harbin, Heilongjiang, 150001, China
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The Second Affiliated Hospital of Guilin Medical University
Guilin, Guangxi, 541199, China
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The Second Hospital of Dalian Medical University
Dalian, Liaoning, 116027, China
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The Second Hospital of Shanxi Medical University
Taiyuan, Shanxi, 030001, China
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The Second Norman Bethune Hospital of Jilin University
Changchun, Jilin, 130041, China
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The Seventh Peoples Hospital of Zhengzhou
Zhengzhou, Henan, 450016, China
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The Sixth Affiliated Hospital Sun Yat-sen University
Guangzhou, Guangdong, 510655, China
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The Third Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, 510630, China
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The Third Peoples Hospital of Huizhou
Huizhou, Guangdong, 516002, China
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Tianjin Chest Hospital
Tianjin, Tianjin Municipality, 300222, China
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Tianjin First Central Hospital
Tianjin, Tianjin Municipality, 300192, China
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Tianjin First Central Hospital
Tianjin, Tianjin Municipality, 300384, China
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Tianjin Huanhu Hospital
Tianjin, Tianjin Municipality, 300350, China
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Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, 300025, China
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Tianjin Peoples Hospital
Tianjin, Tianjin Municipality, 300120, China
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Tongji Hospital of Tongji University
Shanghai, Shanghai Municipality, 200065, China
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Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei, 430022, China
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Wuhan No 1 Hospital
Wuhan, Hubei, 430022, China
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Wuhan Third Hospital-Tongren Hospital of Wuhan University
Wuhan, Hubei, 430060, China
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Wuxi Peoples Hospital
Wuxi, Jiangsu, 214023, China
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Xiangya Hospital Central South University
Changsha, Hunan, 410008, China
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Xinhua Hospital Affiliated To Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, 200092, China
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Yanan Hospital of Kunming City
Kunming, Yunnan, 473009, China
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Zhuhai Peoples Hospital
Zhuhai, Guangdong, 519050, China
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Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, 510280, China
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Zibo central Hospital
Zibo, Shandong, 255030, China
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the First Peoples Hospital of Xiaoshan District Hangzhou
Hangzhou, Zhejiang, 311201, China
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