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New imaging technique could save lives after heart attacks

NCT ID NCT05818475

Disease control Sponsor: University Hospital of Ferrara Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways to decide which blocked arteries to stent in heart attack patients who have multiple blockages. One method uses standard X-ray images; the other uses a computer analysis of those images to measure blood flow. About 1,800 patients will be randomly assigned to one approach. The goal is to see if the computer-guided method reduces deaths, heart attacks, strokes, or the need for repeat procedures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
angiography-derived fractional flow reserve (FFR) imaging
What this could lead to
If successful, this could lead to a more precise way to decide which blockages need stenting, potentially reducing deaths, heart attacks, and strokes in heart attack patients.
What could go wrong
This is a large trial, but the new method may not prove better than standard visual assessment. There is also a risk of kidney injury or bleeding from the procedure itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,823 people

The number who actually took part.

Started

May 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ST-segment elevation myocardial infarction with indication to invasive management * Multi-vessel disease defined as at least 1 non-culprit coronary artery lesion at least 2.5 mm in diameter deemed at visual estimation with a diameter stenosis % ranging from 50 to 99% amenable to successful treatment with PCI * Successful treatment of culprit lesion Exclusion Criteria: * Planned surgical revascularization * Left main as non-culprit lesion * Non-cardiovascular co-morbidity reducing life expectancy to \< 1 year * Any factor precluding 1-year follow-up * Prior Coronary Artery Bypass Graft (CABG) Surgery * Impossibility to identify a clear culprit lesion * Presence of a chronic total occlusion (CTO)

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Conditions

The condition(s) this trial relates to.

coronary artery disorder myocardial infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myocardial infarction

Contacts and locations

Locations

  • AORN Sant'Anna e San Sebastiano

    Caserta, Italy

  • ASST Papa Giovanni XXIII

    Bergamo, Italy

  • AUSL Bologna Ospedale Maggiore

    Bologna, BO, 40133, Italy

  • AUSL Piacenza

    Piacenza, PC, Italy

  • AUSL Romagna Ospedale degli Infermi Rimini

    Rimini, RN, Italy

  • AUSL Romagna Santa Maria delle Croci Ravenna

    Ravenna, Italy

  • Arcispedale Santa Maria Nuova di Reggio Emilia

    Reggio Emilia, RE, 42123, Italy

  • Azienda Ospedaliero Universitaria Integrata di Verona

    Verona, VR, Italy

  • Azienda Ospedaliero Universitaria Mater Domini

    Catanzaro, Italy, Italy

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, Italy

  • Azienda Ospedaliero Universitaria di Ferrara

    Ferrara, FE, 44124, Italy

  • Azienda Ospedaliero Universitaria di Parma

    Parma, PR, Italy

  • NICVD Karachi

    Karachi, Pakistan

  • Ospedale Annunziata

    Cosenza, Italy, 87100, Italy

  • Ospedale Civile di Baggiovara

    Baggiovara, MO, Italy

  • Ospedale Maggiore della Carità Novara

    Novara, Italy

  • Ospedale Mater Salutis Legnago

    Legnago, VR, Italy

  • Ospedale Santa Maria Goretti

    Latina, Italy

  • Ospedale Santa Maria della Misericordia Rovigo

    Rovigo, RO, Italy

  • Ospedale dell'Angelo Mestre

    Mestre, VE, 30100, Italy

  • Ospedale di Bolzano

    Bolzano, Italy, 39100, Italy

  • Policlinico Casilino

    Roma, Italy

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Other studies related to the condition(s) this trial covers.