Eye ultrasound may predict brain damage after cardiac arrest
NCT ID NCT04838418
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a simple, painless eye ultrasound can help doctors predict brain damage and survival in people who have had a cardiac arrest. Researchers will measure the optic nerve sheath diameter in 80 adults and compare it with other tests. The goal is to find a fast, low-cost way to identify patients who may not recover, so treatment decisions can be made more accurately.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 80 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2021
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Male and female patients after cardiac arrest with subsequent ROSC, 18 years of age and older
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * age of 18 years or older * out of hospital cardiac arrest of non-traumatic cause with CPR and subsequent ROSC * Glasgow coma scale (GCS) ≤ 7 or sedation 30 minutes after ROSC achievment Exclusion Criteria: * unavailable first measurment of the optic nerve sheath diameter (ONSD) measured by transorbital ultrasonography 24±6 hours after ROSC achievement * refractory cardiac arrest * craniocerebral injury * intracranial tumor * active intracranial bleeding * haemorrhagic stroke and/or subarachnoid haemorrhage in the last 3 months * facial trauma affecting the eye area * active neuroendocrine tumor, small cell lung cancer, non-small cell lung * CPC 3-5 before cardiac arrest * sclerosis multiplex and/or optic neuritis of other etiology
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Hospital Plzen
Pilsen, Czechia
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Other studies related to the condition(s) this trial covers.
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