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Can cooling after cardiac arrest change how the body burns fuel?

NCT ID NCT06575101

Knowledge-focused Sponsor: Tang Ziren Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study looks at how therapeutic cooling after cardiac arrest affects the body's energy expenditure and which nutrients (sugars, fats, proteins) are burned for fuel. About 40 unconscious patients will be cooled to either 33°C or 36°C and given a fixed nutrition plan. Researchers will measure energy use at several time points during cooling and rewarming, and track neurological recovery at 28 days. The goal is to understand how cooling changes metabolism, which could help guide nutrition care for these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Target temperature management (cooling to 33°C or 36°C)
What this could lead to
If successful, this could help doctors tailor nutrition for unconscious cardiac arrest patients during cooling, potentially improving recovery.
What could go wrong
This is a small, observational study, so it cannot prove cause and effect. Results may not apply to all patients, and measuring energy use in critically ill patients is challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients(age \>18 years) who have been successfully resuscitated from cardiac arrest who meet the inclusion criteria.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Be admitted to the emergency department of Beijing Chao-yang Hospital, Capital Medical University; * Successfully resuscitated, and are unconscious after restoration of spontaneous circulation (ROSC); * Be admitted to the intensive care unit (ICU) for advanced life support such as endotracheal intubation after restoration of spontaneous circulation (ROSC); * Accepted target temperature management (TTM) therapy after restoration of spontaneous circulation (ROSC); Exclusion Criteria: * Age \> 18 years old； * Incomplete clinical data and loss of follow-up; * Traumatic brain injury or cerebrovascular accident revealed by computed tomography (CT)； * Severe metabolic abnormalities are known: cachexia, thyroid dysfunction, and cancer； * Indirect calorimetry measurement is not possible such as sustained oxygen concentration \> 70%； * There were no signs of resuscitation at the time of admission；

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Conditions

The condition(s) this trial relates to.

cardiac arrest nutritional disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest Nutrition Resting energy expenditure Targeted temperature management

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing chao-yang Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, China

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