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New nerve block combo may cut opioid use after heart surgery

NCT ID NCT07658521

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding two ultrasound-guided nerve blocks to standard pain relief can lower opioid use and pain after coronary artery bypass grafting. 88 adults having elective bypass surgery will be randomly assigned to receive either the nerve blocks plus standard medications or standard medications alone. Pain scores, opioid use, and recovery milestones will be tracked for 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine
What this could lead to
If successful, this approach could reduce reliance on opioid painkillers and improve recovery after heart surgery.
What could go wrong
This is a small, early-stage trial (88 participants) testing a procedure, not a new drug. The nerve blocks may not significantly reduce pain or opioid use, and there are risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 88 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-65 years. * Scheduled for elective, isolated CABG via median sternotomy. * American Society of Anesthesiologists (ASA) physical status II-III. * Ability to understand the study procedures, provide written informed consent, and reliably report pain scores using the NRS. Exclusion Criteria: * Emergency surgery or pre-operative hemodynamics instability. * Known allergies or hypersensitivity to local anesthetics, paracetamol, morphine, or any study medication. * Coagulopathy, uncontrolled bleeding risk, or therapeutic anticoagulation that cannot be safely withheld per institutional guidelines (INR \> 1.5; platelets \< 100 × 10⁹/L at time of block). * Local infection or cellulitis at any planned injection site on the anterior or lateral chest wall. * Pre-existing chronic pain syndrome requiring daily opioid analgesia or known opioid dependence. * Significant cognitive impairment, severe psychiatric disorder, or inability to reliably use pain scales. * History of prior thoracic surgery or major chest wall deformity distorting anatomy or limiting the ultrasound window. * Pregnancy or breastfeeding. * Any other condition judged by the investigator to represent unacceptable risk or preclude study participation. * Patient refusal or withdrawal of consent.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain following coronary artery bypass grafting (CABG)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ain Shams University Hospitals

    Cairo, Cairo Governorate, 1181, Egypt

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