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Can a Triple-Dose of ICU tweaks save more brains after cardiac arrest?

NCT ID NCT05564754

Disease control Sponsor: Region Skane Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose fever control, high vs. standard blood pressure target). The goal is to see which approach leads to more people alive and with good brain function at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Feedback-controlled temperature device; vasopressors; sedation drugs
What this could lead to
If it works, this could establish a standard ICU protocol to improve survival and brain function after cardiac arrest.
What could go wrong
This is a large trial but still testing combinations of existing treatments; results may not show a clear winner or may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 3,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Out-of-hospital cardiac arrest 2. Sustained ROSC - defined as 20 minutes with signs of circulation without the need for chest compressions 3. Unconsciousness defined as not being able to obey verbal commands (FOUR-score motor response of \<4) or being intubated and sedated because of agitation after sustained ROSC. 4. Eligible for intensive care without restrictions or limitations 5. Inclusion within 4 hours of ROSC Exclusion Criteria: 1. On ECMO prior to randomization 2. Pregnancy 3. Suspected or confirmed intracranial hemorrhage 4. Previously randomized in the STEPCARE trial 5. Trauma or hemorrhage being the presumed cause of arrest

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Hypoxia, Brain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest with successful resuscitation Hypoxia, brain

Contacts and locations

Locations

  • Austin Hospital

    Melbourne, Victoria, Australia

  • Bern University Hospital

    Bern, Switzerland

  • Bristol Royal Infirmary

    Bristol, United Kingdom

  • Cardiff University Hospital

    Cardiff, United Kingdom

  • Centre Hospitalier de Luxembourg

    Luxembourg, Luxembourg

  • Charite University Hospital

    Berlin, Germany

  • Christchurch Hospital

    Christchurch, New Zealand

  • DCCM ICU

    Auckland, New Zealand

  • Essex Cardiothoracic Centre

    Basildon, United Kingdom

  • Ghent University Hospital

    Ghent, 9000, Belgium

  • HUB Hôpital Erasme

    Brussels, 1077, Belgium

  • Hallands hospital

    Halmstad, Halland County, Sweden

  • Helsingborg Hospital

    Helsingborg, Skåne County, Sweden

  • Helsinki Helsingforgs University Central Hospital

    Helsinki, Finland

  • Jorvi Hospital

    Espoo, Finland

  • Jyväskylä Hospital

    Jyväskylä, Finland

  • Kalnes Hospital

    Kalnes, Norway

  • Karlstad hospital

    Karlstad, Sweden

  • Karolinska University Hospital

    Stockholm, Sweden

  • King Abdulaziz Medical City

    Riyadh, Saudi Arabia

  • Kings College Hospital

    London, United Kingdom

  • Kuopio University Hospital

    Kuopio, Finland

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Liverpool Hospital

    Liverpool, New South Wales, Australia

  • Lübeck University Hospital

    Lübeck, Germany

  • Meilahti Hospital

    Helsinki, 00290, Finland

  • Middlemore ICU

    Auckland, New Zealand

  • Nepean Hospital

    Kingswood, New South Wales, Australia

  • North Estonia Medical Centre, Tallinn

    Tallinn, 13409, Estonia

  • North Shore ICU NZ

    Auckland, New Zealand

  • Oslo University Hospital

    Oslo, Norway

  • Oulu University Hospital

    Oulu, Finland

  • Princess Alexandra Hospital

    Brisbane, Queensland, Australia

  • Royal North Shore Hospital

    Sydney, New South Wales, Australia

  • Sahlgrenska University Hospital

    Gothenburg, Sweden

  • San Martino Hospital Genova

    Genova, Italy

  • Skaraborg Hospital Skovde

    Skövde, Sweden

  • Skåne University Hospital

    Lund, Skåne County, Sweden

  • Skåne University Hospital Malmö

    Malmö, Skåne County, Sweden

  • Soerlandet Hospital Arendal

    Arendal, Norway

  • St Bartholomew's Hospital

    London, United Kingdom

  • St Gallen Hospital

    Sankt Gallen, Switzerland

  • St George Hospital

    Sydney, New South Wales, Australia

  • St Georges University Hospital

    London, United Kingdom

  • St Vincents University Hospital

    Dublin, Ireland

  • Stavanger University Hospital

    Stavanger, Norway

  • Tampere University Hospital

    Tampere, Finland

  • Tan Tock Seng Hospital

    Singapore, Singapore

  • The Prince Charles Hospital

    Brisbane, Queensland, Australia

  • The Sutherland Hospital

    Sydney, New South Wales, Australia

  • Tubingen University Hospital

    Tübingen, Germany

  • University Hospital Zürich

    Zurich, Switzerland

  • University Hospital of Umeå

    Umeå, Sweden

  • Wellington Hospital

    Wellington, New Zealand

  • Whangarei ICU

    Northland, New Zealand

  • Ziekenhuis Oost-Limburg Hospital

    Lanaken, 3620, Belgium

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