Could a smartphone alert replace daily blood thinners for AF?
NCT ID NCT06922695
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only restart when an implanted heart monitor detects an AF episode and sends a smartphone alert. The goal is to see if this on-demand strategy can reduce bleeding risks while still preventing strokes, and whether it is safe and acceptable to patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Pill-in-pocket anticoagulation (taking blood thinners only when an atrial fibrillation episode is detected, instead of daily)
- What this could lead to
- If successful, this approach could allow some people with atrial fibrillation to take blood thinners only when needed, reducing bleeding risks and offering a new treatment option.
- What could go wrong
- This is a small pilot study, so results may not apply broadly. There is a risk that intermittent anticoagulation could increase stroke risk if episodes are missed or alerts are delayed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2025
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Participant is willing and able to give informed consent for participation in the trial. 2. Understand the risk and willing to discontinue oral anticoagulation (OAC). 3. Any gender aged 18 years or above. 4. Non-valvular paroxysmal atrial or persistent atrial fibrillation (AF) with a current rhythm control strategy. Paroxysmal patients must have \< 3 documented or symptomatic episodes of \>1 hour duration in the previous 3 months. Persistent patients must have been in continuous sinus rhythm for at least 4 weeks prior to enrolment. 5. CHA2DS2-VASc score between 1 and 3 in men and between 2 and 4 in women. 6. Able to take direct-acting oral anticoagulant (DOAC) in guideline recommended doses. 7. Left atrial (LA) diameter on echocardiogram less than 5 cm (anteroposterior dimensions) or LA volume less than 48 ml/m2. Exclusion Criteria: 1. Any contraindication to OAC therapy with a DOAC in guideline recommended doses. 2. Mechanical heart valve prosthesis or moderate-to-severe mitral valve stenosis. 3. Permanent atrial fibrillation. 4. Hypertrophic cardiomyopathy. 5. Documented previous thromboembolic event (stroke, transient ischaemic attack or systemic embolism). 6. Spontaneous echo contrast observed in any imaging modality. 7. History of intracardiac thrombi. 8. History of congenital heart disease. 9. Severe chronic renal disease (eGFR \<15 ml/m) or on renal replacement therapy. 10. Pregnant or planning pregnancy. 11. Indication for OAC other than atrial fibrillation. 12. Inability to comply with protocol. 13. Smartphone with operating system (OS) not compatible with MyCareLink Heart app. 14. Contraindication for implantable cardiac monitor. 15. Visual or physical impairment that prevents ability to read and acknowledge smartphone/watch notifications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Oxford University Hospitals NHS Trust, John Radcliffe Hospital
Oxford, Oxfordshire, OX3 9DU, United Kingdom
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Other studies related to the condition(s) this trial covers.
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