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Could a broccoli sprout compound protect aging hearts?

NCT ID NCT05408559

Disease control Sponsor: Texas Tech University Health Sciences Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study tests whether a supplement called sulforaphane, found in broccoli sprouts, can help prevent age-related declines in heart function. Researchers will give the supplement or a placebo to adults over 60 with a type of heart failure called HFpEF. They will measure heart function, exercise ability, and muscle strength before and after 24 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sulforaphane (broccoli sprout extract)
What this could lead to
If it works, this could point toward a simple dietary supplement to help protect heart function in older adults.
What could go wrong
This is an early-phase trial with a small number of participants, so results may not apply broadly. The supplement may not improve heart function or exercise capacity as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Started

Jul 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 60 years * Diagnosis of HFpEF (HF symptoms with a normal EF (\>/=50 %) * Ability to walk more than 500 feet (by self-report) * Willing to avoid taking all over the counter antioxidant phytochemical supplements (vegetable or fruit-containing supplement pills) during the study Exclusion Criteria: * Inability to provide informed consent * Diagnosis of active cancer * Inability to read and understand the SF-36 in English * Participants using over the counter antioxidant supplements * Participants with pulmonary or other issues which restrict walking capacity * On oxygen therapy

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Conditions

The condition(s) this trial relates to.

diastolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diastolic dysfunction Diastolic heart failure Systolic dysfunction

Contacts and locations

Locations

  • Texas Tech University Health Sciences Center (TTUHSC)

    Lubbock, Texas, 79430, United States

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Other studies related to the condition(s) this trial covers.