Urine-Guided diuretic dosing could revolutionize ER heart failure care
NCT ID NCT04481919
First seen Jan 05, 2026 · Last updated Jun 23, 2026 · Updated 26 times
Summary
This study tests whether using urine sodium levels to guide diuretic dosing improves outcomes for emergency department patients with acute heart failure. About 474 adults with fluid overload will be randomly assigned to either the urine-guided protocol or standard care. The goal is to see if this personalized approach leads to better clinical status and less congestion.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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VA Tennessee Valley Health Service
Nashville, Tennessee, 37232, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
diuretic therapy (furosemide or similar) guided by urine sodium levels
What this could lead to
If successful, this could provide a more effective way to manage fluid overload in acute heart failure, reducing hospital stays and improving recovery.
What could go wrong
This is a Phase 2 trial with 474 participants, so results are preliminary. The protocol may not outperform standard care, and diuretics carry risks like kidney strain or electrolyte imbalances.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.