New Dual-Pacing strategy could boost heart function in failure patients
NCT ID NCT07664189
First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times
Summary
This pilot study tests whether a new pacing method called LOT-CRT, which paces two areas of the heart at once, works better than standard pacing alone in people with heart failure. Ten patients will each receive a special pacemaker and try both pacing settings for 6 months each. Researchers will compare heart function, symptoms, and quality of life to see which approach is more effective.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cardiac resynchronization therapy pacemaker (CRT-P) with leads in the left bundle branch area and coronary sinus
- What this could lead to
- If successful, this could point toward a more effective pacing strategy to improve heart function and quality of life in heart failure patients.
- What could go wrong
- This is a very small pilot study with only 10 patients, so results may not apply to everyone. The crossover design is exploratory, and the approach may not show clear benefits over standard pacing.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 10 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2026
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years 2. Standard CRT-P indications according to ESC 2021 (EF ≤50%, QRS ≥130 ms, sinus rhythm or controlled AF) 3. NYHA class II-IV 4. Coronary venous anatomy suitable for placement of a coronary sinus electrode. 5. Signed informed consent. 6. Successful implantation of electrodes in the coronary sinus and in the left bundle branch area (LBBAP) Exclusion Criteria: 1. Concomitant indication for implantation of an implantable cardioverter-defibrillator (ICD) or CRT-D 2. Significant uncorrected valvular disease or scheduled or anticipated cardiac surgery during the study period. 3. Anatomical or technical contraindication for lead implantation in the coronary sinus or for lead implantation in the coronary sinus (such as sinus stenosis, coronary sinus branches unsuitable for cannulation, inability to advance and/or stabilize the lead, among others) 4. Persistent atrial fibrillation with uncontrolled rate 5. Comorbidities that may limit life expectancy to \<1 year 6. Participation in another clinical trial that could confound the evaluation of results within the last 6 months. 7. Pregnancy or inadequate contraception 8. In the researcher's opinion, the participant would not comply with the activities and visits outlined in the study protocol
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Clinica CardioVID
Medellín, Antioquia, 050036, Colombia