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Arm cuff before surgery may shield heart, trial suggests

NCT ID NCT02427867

Disease control Sponsor: Università Vita-Salute San Raffaele Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether briefly inflating a blood-pressure cuff on the arm before non-cardiac surgery can reduce heart damage in high-risk patients. Over 1,200 participants will receive either the cuff procedure or no intervention. The goal is to see if this simple, low-cost technique lowers cardiac troponin levels, a marker of heart injury.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remote ischemic preconditioning (blood-pressure cuff inflation on the arm)
What this could lead to
If it works, this could offer a safe, low-cost way to prevent heart complications during non-cardiac surgery.
What could go wrong
This is the first large trial in non-cardiac surgery, so results are uncertain. The effect may be smaller than hoped or not translate to better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,217 people

The number who actually took part.

Started

Apr 2015

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * written informed consent * intermedial and high risk non cardiac surgery * general anesthesia * ongoing or recently suspended antiplatelet therapy Exclusion Criteria: * pregnancy * planned locoregional anesthesia without general anesthesia * unstable or ongoing angina * recent (\< 1 month) or ongoing acute myocardial infarction * inclusion in other randomised controlled studies in the previous 30 days * peripheral vascular disease affecting the upper limbs * cardiac surgery

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Conditions

The condition(s) this trial relates to.

myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myocardial ischemia Surgery

Contacts and locations

Locations

  • A.O.U. Pisana

    Pisa, Italy

  • Astana Medical University

    Astana, 010000, Kazakhstan

  • Azienda Ospedaliero Universitaria Careggi

    Florence, 50139, Italy

  • Azienda Sanitaria Universitaria Friuli Centrale "Santa Maria della Misericordia"

    Udine, 33100, Italy

  • Azienda Universitaria Ospedaliero Pisana

    Pisa, 56100, Italy

  • E.O. Ospedali Galliera

    Genova, 16128, Italy

  • Fondazione IRCCS. Istituto Neurologico Carlo Besta

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Rome, 00136, Italy

  • Fondazione Policlinico Universitario Campus Bio-Medico di Roma

    Rome, 00128, Italy

  • Fundación Cardioinfantil-Instituto de Cardiología

    Bogotá, 110131, Colombia

  • Humanitas Clinical Institute

    Rozzano, Lombardy, 20100, Italy

  • I.M. Sechenov First Moscow State Medical

    Moscow, Russia

  • IRCCS San Raffaele Scientific Institute

    Milan, 20132, Italy

  • Institute of Cardiovascular Diseases "Dedinje"

    Belgrade, Serbia

  • Loginov Moscow Clinical Scientific Center

    Moscow, 111123, Russia

  • National University Hospital

    Singapore, 119074, Singapore

  • Oncological Center No. 1 of the S. S. Yudin City Clinical Hospital of the Moscow Department of Health

    Moscow, 117152, Russia

  • Ospedale Cardinal Massaia

    Asti, 14100, Italy

  • Ospedale Regionale di Lugano

    Lugano, Switzerland

  • Saint-Petersburg State University Hospital

    Saint Petersburg, Russia

  • ULSS 4 Veneto Orientale, Ospedale di San Donà di Piave

    San Donà di Piave, 30027, Italy

  • University Hospital Centre Zagreb

    Zagreb, 10000, Croatia

  • Università degli studi della Campania Luigi Vanvitelli

    Naples, 80138, Italy

  • V.Negovsky Reanimatolgy Research Institute

    Moscow, Russia

  • Valle Olona Po hospital

    Busto Arsizio, Varese, Italy

  • Xijing Hospital

    Xi'an, 710032, China

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