New study aims to spot hidden heart attack risks with High-Tech imaging

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presenting to the clinic with a diagnosis of Acute Coronary Syndrome. * Having a significant (total or subtotal) culprit lesion detected during the index angiography procedure and having successfully undergone percutaneous coronary intervention (PCI) for this lesion. * Having at least one distant non-culprit lesion with moderate stenosis (between 50% and 90%) according to visual angiographic evaluation in coronary arteries (or side branches with a diameter \>2.5 mm) that are not major epicardial and not major left main coronary arteries. * Having TIMI III flow in the vessel containing the non-culprit lesion to be evaluated. * The patient being able to understand the nature of the study and signing the written informed consent form. * Patients for whom intracoronary hemodynamic evaluation is planned for treatment planning of the non-culprit lesion after the index procedure. Exclusion Criteria: Clinical Exclusion Criteria: * Advanced renal insufficiency to the extent that the patient cannot tolerate the additional contrast load required for intracoronary imaging (IC-OCT) (e.g., eGFR \< 30 mL/min/1.73 m²). * Known serious allergy or absolute contraindication to the hyperemic agents to be used (e.g., adenosine, papaverine), iodinated contrast agents, or mandatory antiplatelet/anticoagulant therapy. * Patients presenting to the hospital due to heart failure and cardiogenic shock. * Additional investigation required due to in-stent restenosis of a non-culprit vessel. * Patients with blood disorders, bleeding disorders, cancer, end-stage liver or kidney failure, patients with active bleeding, and pregnant women. Angiographic and Procedural Exclusion Criteria: * Presence of significant stenosis in the left main coronary artery (LMCA) or the patient having previously undergone coronary artery bypass graft (CABG) surgery. * Failure of PCI on the culprit lesion in the index procedure, no-reflow, etc. The vessel containing the non-culprit lesion has technical impediments that prevent safe passage of the IC-OCT catheter or pressure/flow wire (e.g., excessive tortuosity, advanced angulation, very dense calcification, or chronic total occlusion \[CTO\]).