Heart failure checklist aims to boost lifesaving drug use
NCT ID NCT06847438
First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times
Summary
This study tests whether giving heart failure patients a one-page checklist of recommended medications helps doctors prescribe them more often. The checklist lists guideline-approved drugs and doses for heart failure with reduced ejection fraction. Researchers will enroll 4000 patients across cardiology clinics to see if this simple tool increases use of these lifesaving medications.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- EPIC-HF checklist (a one-page patient activation tool listing recommended heart failure medications)
- What this could lead to
- If this works, it could help more heart failure patients get the right medications, potentially improving their health and reducing hospital visits.
- What could go wrong
- This is a large but early-stage behavioral study, not testing a new drug. The checklist may not change prescribing habits as hoped, and results may vary across clinics.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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3,966 people
The number who actually took part.
- Started
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Mar 2025
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ejection fraction (EF) less than or equal to 40% by echocardiogram performed in the prior 18 months * Diagnosis of heart failure Exclusion Criteria: * Heart failure (HF) etiology for which GDMT is not indicated: including hypertrophic or restrictive cardiomyopathy (e.g. amyloid cardiomyopathy), constrictive pericarditis, or complex congenital heart disease * End-stage HF requiring continuous inotrope infusion, heart transplant, or left ventricular assist device * Estimated glomerular filtration rate (eGFR) \< 15 mL/min/1.73m\^2 * Any conditions other than HF that are likely to alter the patient's status over 6 months, indicated by active hospice status
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Emory Johns Creek Hospital
Johns Creek, Georgia, 30097, United States
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Emory Saint Joseph's Hospital
Atlanta, Georgia, 30308, United States
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Emory University Hospital
Atlanta, Georgia, 30322, United States
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Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a smartphone app keep heart failure patients out of the hospital?
- Can better training get doctors to talk about what matters most to dying veterans?
- Can AI read heart ultrasounds as well as trained sonographers?