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Exercise may rewire heart cells: new study in heart failure patients

NCT ID NCT07582094

Knowledge-focused Sponsor: Chang Gung Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how high-intensity interval training (HIIT) changes heart cells in people with heart failure. Forty stable patients were split into two groups: one did 36 sessions of HIIT plus standard medication, the other took medication only. Researchers measured fitness, heart function, and cellular changes to understand exercise's benefits at a molecular level.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high-intensity interval training
What this could lead to
If successful, this could reveal how exercise improves heart health at a cellular level, potentially guiding better rehabilitation programs for heart failure patients.
What could go wrong
This is a small, completed study with only 40 participants, so results may not apply to all heart failure patients. It focuses on biological markers, not direct treatment outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Aug 2019

Finished

Jul 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with heart failure, diagnosed according to the Framingham HF diagnostic criteria (McKee et al. N Engl J Med 1971, 285:1441-1446), who had stable clinical presentations greater than 4 weeks and received individualized patient education under optimized guideline-based management (Mao et al. J Cardiovasc Med (Hagerstown) 2015, 16:616-624), were initially surveyed. Exclusion Criteria: * Individuals aged \<20 years and \>80 years * Pregnancy * Cardiac transplantation within the next 6 months * Moderate to severe chronic obstructive pulmonary disease * Decompensated HF * Non-cardiac disease prohibiting cycling exercise * Estimated glomerular filtration rate of \< 30 mL/min/1.73 m\^2 * Absolute contraindications for exercise suggested by the American College of Sports Medicine (Pescatello et al. ACSM's guidelines for exercise testing and prescription. 9th ed. Philadelphia, PA.: Wolters Kluwer/Lippincott Williams \& Wilkins; 2014).

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Conditions

The condition(s) this trial relates to.

heart failure Motor Activity Ventricular Remodeling

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

Contacts and locations

Locations

  • Keelung Chang Gung Memorial Hospital

    Keelung, 204, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.