Chang Gung Memorial Hospital

This study tests a new drug called HCB101 combined with standard treatments (cetuximab or bevacizumab plus chemotherapy) in people with advanced or metastatic colorectal cancer. The goal is to find a safe dose and see if the combination shrinks tumors. About 40 adults will partic…

This study tests whether adding proton radiotherapy to standard immunotherapy (atezolizumab and bevacizumab) can better control advanced liver cancer that cannot be removed by surgery. About 45 adults with unresectable hepatocellular carcinoma will receive the combination therapy…

This study tests whether adding Kremezin (AST-120) to standard care can help people with acute kidney disease recover better. The goal is to lower harmful toxins in the blood and prevent the disease from becoming chronic. About 100 adults aged 18-80 with moderate kidney injury wi…

This study tests whether transplanting healthy gut bacteria (fecal microbiota transplantation) can help people with severe gut graft-versus-host disease that hasn't responded to steroids. About 35 adults who had a stem cell transplant and now have this complication will receive t…

This study tests an experimental drug called DAOIB in 123 people with mild Alzheimer's disease or mild cognitive impairment. Participants take the drug for 24 weeks and have regular blood tests and memory assessments. The goal is to see if certain blood markers can predict who wi…

This study compares two surgical methods for fixing a torn ACL, the main knee ligament. Forty adults will be randomly assigned to receive either a single-bundle or double-bundle reconstruction, both combined with an extra ligament repair. Researchers will track knee stability, fu…

This study tests a new treatment for people with advanced liver cancer that cannot be removed by surgery. It combines precise proton radiation with two immunotherapy drugs (tremelimumab and durvalumab) to boost the immune system's attack on the tumor. About 45 participants will r…

This study is testing a new combination of three drugs (S-1, nab-paclitaxel, and gemcitabine) in people whose pancreatic cancer has spread to other parts of the body. The goal is to find the safest and most effective dose and to see how well the drugs shrink tumors. About 70 part…

This study tests whether a phenylalanine-free diet can safely lower high blood phenylalanine levels in critically ill adults in the intensive care unit. High phenylalanine is linked to serious problems like brain dysfunction and higher death risk. The diet uses a special milk for…

This study tests adding the immunotherapy drug dostarlimab to standard chemotherapy and radiation for a rare and aggressive type of cervical cancer called small cell neuroendocrine cervical carcinoma. The goal is to see if this combination can delay cancer growth and improve surv…

This study tests whether combining a statin with ezetimibe works better than a statin alone to lower LDL (bad) cholesterol below 70 mg/dL in people who recently had a stroke. About 300 adults with atherosclerosis and high LDL will be randomly assigned to one of the two treatments…

This study is testing whether transferring healthy gut bacteria (via fecal transplant) can improve both stomach issues and autism-related behaviors in 60 people aged 7-30 with autism and gastrointestinal problems. Researchers will measure changes in gut symptoms, social skills, a…

This study tests a non-invasive brain stimulation technique called theta burst stimulation (TBS) on the right inferior frontal gyrus in 60 people with autism aged 8 to 30. The goal is to see if it can reduce core symptoms like social difficulties and repetitive behaviors, and imp…

This study tests whether brief mindfulness breathing, heart rate biofeedback, or pain education before shoulder surgery can reduce pain, improve shoulder function, sleep, and mood afterward. About 120 adults with chronic shoulder pain scheduled for surgery will be randomly assign…

This study tests whether combining an NMDA-enhancing drug with an antioxidant can improve thinking and memory better than the NMDA drug alone. Researchers will enroll 80 people with early Alzheimer's or mild cognitive impairment. Participants will take the combination for 24 week…

This study tests whether an injection made from donated amniotic tissue can reduce pain and improve knee function in people with knee osteoarthritis. About 160 adults with moderate knee arthritis will receive either the amniotic injection, a standard hyaluronic acid injection, or…

This study tests a new rehabilitation program for stroke survivors that combines robot-assisted arm training with task-oriented therapy in a circuit format. The goal is to improve arm movement, daily function, and quality of life. The study will enroll 87 adults who have had a st…

This study is testing whether virtual reality (VR) and mixed reality (MR) games can help stroke survivors improve arm and hand function. About 45 adults who had a stroke will try these high-tech mirror therapy systems or standard therapy. The goal is to see if the VR/MR approache…

This study tests a medicine called DAOIB to see if it can help with memory and thinking problems caused by long COVID. About 40 adults with long COVID and brain fog will take DAOIB for 24 weeks. Researchers will check their thinking skills, mood, and quality of life every 8 weeks…

This study tests if watching online interactive videos can improve bowel symptoms, reduce psychological distress, and boost quality of life in people who have had rectal cancer. About 110 adults with stage I-III rectal cancer will participate. The videos are designed to help mana…

This study tests whether a cushion called DaSuit® can reduce discomfort and improve posture in adults with low back pain that gets worse when sitting. Twenty adults aged 20 to 50 will sit on either the DaSuit® or a placebo cushion for 10 minutes, then have their spine imaged and …

This study looks at whether a multimedia education program (like videos and interactive materials) can reduce anxiety and improve self-care knowledge in people having cataract surgery. About 118 adults will be randomly assigned to receive either standard instructions or the multi…

This study tests if laser acupuncture can reduce shoulder pain and improve movement in people who have had a stroke. About 58 adults with shoulder pain starting 7 days to 6 months after their stroke will receive the treatment. The goal is to see if this needle-free approach helps…

This study tests whether adding low-level laser acupuncture to standard diet and exercise helps obese menopausal women lose more weight and improve body shape. Forty women aged 45-55 with a high BMI or waist-to-hip ratio will receive either lifestyle changes alone or lifestyle ch…

This study looks at whether a simple blood test that finds leftover cancer cells (circulating tumor cells) can help doctors decide if oral cancer patients need extra chemotherapy after their usual treatment. About 100 people who have finished surgery and chemoradiation for oral c…

This study compares newer laser techniques for cataract or vision correction surgery to see which causes less inflammation and helps eyes heal better. Researchers will measure natural antioxidants in tears and eye fluid before and after surgery in 1,000 adults. The goal is to fin…

This study looks at small molecules called microRNA and tumor cells floating in the blood of 300 cancer patients before and after they receive immunotherapy. The goal is to see how these markers change with treatment. No new treatment is given; the study only observes and measure…

This study looks at how getting older and having tired muscles affect a person's balance and walking. Researchers will test 140 healthy adults (young and old) before and after exercises that tire out their arms or legs. The goal is to understand these effects better, not to provi…

This study looks at head and neck cancer patients who had radiation therapy to see how often they develop blood vessel narrowing or brain issues. Researchers will follow 800 adults who received radiation within the last 6 years and have had brain scans. The goal is to better unde…

This study is creating a library of video and audio recordings to help teach and assess clinical skills in occupational therapy. Researchers will record teaching sessions, skill demonstrations, and real therapy interactions involving therapists, trainees, and patients. The goal i…

This study looks at how well people can control their hip muscles and whether that affects their balance, walking, and fall risk. Researchers will compare healthy adults of different ages with people who have Parkinson's disease. The goal is to better understand what causes balan…

This study creates and tests a training program for Care Food Specialists—workers who focus on food preparation and oral health in long-term care. About 150 healthy students in Taiwan will take the course and be assessed on their knowledge, attitudes, and behaviors before and aft…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to identify biological markers that predict disease progression and help create personalized prevention and treatment plans. Part…

This study looks at whether a simple blood test can help doctors predict how well immunotherapy will work for people with head and neck cancer. Researchers will measure certain markers on tumor cells found in the blood and compare them to standard tissue tests. The goal is to mak…

This study is testing a new AI program designed to help nursing home staff and families communicate better. Researchers will develop the AI using real conversations and then test it with 210 residents, families, and staff over 6 months. The goal is to see if the AI improves menta…

This study aims to find out if certain chemicals in the body can predict how well rectal cancer responds to treatment and whether side effects like radiation proctitis occur. Researchers will collect blood, urine, tissue, and stool samples from 250 people with locally advanced re…

This study looks at why cancer patients have a much higher risk of blood clots. Researchers will compare blood samples from 120 people with and without cancer who need a procedure to remove a clot. They aim to understand how tumor cells in the blood may trigger clotting and how c…

This study explores whether artificial intelligence can estimate a person's cognitive test scores by analyzing a short speech recording. 150 adults aged 50 and older will tell a story based on a picture while their voice is recorded. The AI's predictions will be compared to stand…