Can a gout drug cool down artery inflammation in diabetics?
NCT ID NCT04181996
First seen May 07, 2026 · Last updated Jun 19, 2026 · Updated 8 times
Summary
This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly assigned to receive colchicine or a placebo for 6 months. The goal was to see if colchicine could lower inflammation and potentially prevent future cardiovascular events.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Mazankowski Alberta Heart Institute
Edmonton, Alberta, T6G 2B7, Canada
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University of Ottawa Heart Institute
Ottawa, Ontario, K1Y 4W7, Canada
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
colchicine
What this could lead to
If it works, this could point toward a new way to prevent heart attacks and strokes in people with diabetes by targeting inflammation.
What could go wrong
This is a small, early-phase study (115 people) focused on imaging markers, not clinical events. Colchicine may not reduce inflammation enough or could cause side effects like stomach upset.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.