ATHEROSCLEROSIS

This study looks at whether an 8-week stress reduction program can reduce inflammation in the arteries of adults who feel stressed. Researchers will use special scans to measure changes in artery inflammation. The goal is to see if managing stress can help control atherosclerosis…

This study tests whether using just one blood thinner (single antiplatelet therapy) is safer and as effective as two blood thinners (dual antiplatelet therapy) in older adults or those at high risk of bleeding who have had a heart procedure with a drug-coated balloon. About 576 p…

This study tests whether choline fenofibrate, a drug that lowers fats in the blood, can reduce plaque buildup in the neck arteries of people with type 2 diabetes and mixed high cholesterol. About 56 adults will receive either choline fenofibrate or a comparison drug (policosanol)…

This study tests whether ziltivekimab, an anti-inflammatory drug, can reduce inflammation in the artery walls of people with heart disease. About 40 adults aged 50 and older with multiple blocked arteries and high inflammation levels will receive either the drug or a placebo. Res…

This study tests whether two drugs, colchicine and ticagrelor, can reduce inflammation and lower the risk of another stroke or heart attack in people who have already had a stroke. About 2,800 high-risk participants will take these medications alongside standard care. The goal is…

This study tests an experimental drug called selnoflast in 162 people with atherosclerosis (hardened arteries) who are at high risk for heart attacks or strokes. Participants will receive either selnoflast or a placebo on top of their usual heart medications. The goal is to see i…

This study looks at whether a smartphone app can help people with clogged arteries take their statin medication correctly. About 250 adults who need to start a strong statin will either get standard care or standard care plus the app. The main goal is to see if the app helps lowe…

This study tests whether two common blood thinners, clopidogrel and cilostazol, can slow the buildup of plaque in the neck arteries of people with type 2 diabetes. About 120 adults with diabetes and early signs of artery thickening will take one of the two drugs for a year. The g…

This early-stage study tests an injectable drug called IMC-001 in 18 people who recently had a heart attack or unstable angina. The goal is to see if it can safely make artery plaques more stable, reducing the risk of future heart problems. Participants receive either the drug or…

This study looks at whether a 12-week cardiovascular rehabilitation program (exercise training three times a week) can improve artery health and reduce inflammation in adults aged 40-70 with coronary artery disease. Researchers will measure artery thickness, blood vessel function…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study looks at whether adding omega-3 (fish oil) to a common cholesterol-lowering statin can reduce plaque buildup in the carotid arteries of people with type 2 diabetes and high cholesterol. About 105 adults will be randomly assigned to receive either atorvastatin plus omeg…

This study tests a new computer program that helps doctors diagnose blocked heart arteries from CT scans more accurately. Researchers will look at past scans from 1,000 patients to see if the software can reduce the need for invasive tests like angiograms. The goal is to make dia…

This study tests whether starting cholesterol-lowering treatment in the emergency department can help prevent future heart attacks and strokes. It involves 130 adults aged 40-75 who are at risk for heart disease but not yet on preventive medication. The approach follows national …

This study tests whether metformin, a common diabetes medicine, can lower the risk of death, heart attacks, and strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will be followed over time to see if metformin helps …

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect blood, tissue, and perform imaging tests like MRI and CT scans. The goal is to improve diagnosis and understanding of these conditions. P…

This study aims to create a smart computer program that helps doctors better understand the sounds from a handheld device used to check blood flow in arteries. Many doctors have little training in using this device, which can lead to mistakes or delays in diagnosing problems like…

This study looks at how a gene called TMEM230 might be involved in atherosclerosis, the buildup of fatty plaques in arteries that can lead to heart attacks and strokes. Researchers will analyze gene activity in blood and artery samples from 12 adults undergoing vascular surgery. …

This study looks at whether eating too much protein, especially from animal sources, might increase the risk of heart disease. Researchers will study blood samples from 24 adults aged 45-75 to see how protein affects immune cells linked to artery plaque buildup. The goal is to un…

This study looks at whether an 8-week stress reduction program can lower inflammation in the arteries of adults with stable heart disease. Participants must feel stressed and have a history of heart problems. Researchers will use special PET/MRI scans to measure changes in inflam…

This study looks at people with lipid disorders—conditions where fats like cholesterol are too high or too low in the blood. Researchers want to learn how these fats cause diseases like hardening of the arteries. Up to 2,000 adults and children (ages 2 and up) will have medical t…

This study looks at why heart disease affects women differently than men, especially after menopause. Researchers will measure inflammation and hormone levels in 6,000 women with chest pain. The goal is to understand how these factors influence heart attack risk and recovery, lea…

This study aims to learn more about rare genetic disorders that affect fat levels in the blood, such as too much or too little cholesterol or triglycerides. Researchers will follow 1,500 people aged 10 and older for up to 20 years to see how these conditions change and respond to…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study follows 2000 adults with suspected coronary artery disease who have had special imaging or pressure tests inside their heart arteries. Researchers will track major heart events like death, heart attack, or repeat procedures over many years. The goal is to learn which f…

This study looks at how the immune system's first response (innate immunity) reacts to certain environmental triggers. Researchers want to understand if these reactions are linked to long-term illnesses like asthma, heart disease, and cancer. Healthy volunteers aged 18 to 45 will…