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Can shedding pounds reboot the Heart's exercise engine?

NCT ID NCT06576050

Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to understand the link between obesity, exercise intolerance, and HFpEF, and whether weight loss can improve heart function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Gastric sleeve surgery (weight loss surgery)
What this could lead to
If successful, this could clarify whether weight loss surgery can improve exercise tolerance and potentially reverse some signs of heart failure with preserved ejection fraction.
What could go wrong
This is a small, early study (21 participants) that only observes changes, not a controlled trial. Results may not apply to all patients, and surgery carries inherent risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

21 people

The number who actually took part.

Started

Jan 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects undergoing gastric sleeve bypass weight loss procedure

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for weight loss surgery (gastric sleeve procedure) * 40 years or older * PMH one or more of the following: 1. Diabetes Mellitus 2. Hypertension requiring medical treatment 3. Age \>65 years 4. History of HFpEF 5. Echocardiographic findings: left atrial enlargement (LAE), left ventricular hypertrophy (LVH), or right ventricular systolic pressure \>40 mmHg (RVSP) Exclusion Criteria: * Previous Bariatric surgery * Pregnancy * History of systolic heart failure, past or present LVEF of \<40% * Inability to perform exercise testing on a cycle ergometer (i.e. orthopedic conditions that preclude cycling or walking, recent systemic illness that compromises exercise capacity). * Any contraindication to performing exercise testing or any history of ventricular arrhythmia, any recent (within the last 3 months) or untreated supraventricular arrhythmia, elevated blood pressure at the time of presentation for exercise testing (\>155 mmHg systolic, or \>95 mmHg diastolic blood pressure), active or recent exacerbation of congestive heart failure, or history of reactive airways disease that is induced by exercise). * Acute myocardial infarction (3-5 days) or unstable angina * Uncontrolled symptomatic arrhythmias * Active endocarditis * Acute myocarditis or pericarditis * Symptomatic severe aortic stenosis * Acute pulmonary embolism or DVT * Suspected dissecting aneurysm * Uncontrolled asthma * Room air desaturation to \<85% * Acute non-cardiopulmonary disorder that may affect exercise performance (infection, orthopedic problem)

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Conditions

The condition(s) this trial relates to.

diastolic heart failure heart failure Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure Heart failure with preserved ejection fraction Obesity Weight loss

Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.