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Can induced hypothermia save more lives after In-Hospital cardiac arrest?

NCT ID NCT07086703

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 4 times

Summary

This trial tests whether cooling patients to 33°C (therapeutic hypothermia) improves survival and brain function compared to keeping them at normal body temperature after an in-hospital cardiac arrest. About 788 comatose adults who had a cardiac arrest in the hospital will be randomly assigned to either cooling or controlled normothermia. The main goal is to see if more patients have a good neurological outcome at 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Induced hypothermia (cooling to 33°C)
What this could lead to
If cooling works, it could become a standard treatment to improve survival and brain recovery after in-hospital cardiac arrest.
What could go wrong
This is a large but early-stage trial, and previous studies have shown mixed results. Cooling may not improve outcomes and could cause side effects like infection or heart rhythm problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 788 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * IHCA (unwitnessed IHCA with initial asystole; these patients may still be eligible if visible or audible signs of life were witnessed within 10 minutes after IHCA (no-flow duration ≤10 minutes, in keeping with the non-inclusion criteria for HYPERION study). * Sustained ROSC (Return Of Spontaneous Circulation) defined as signs of circulation for 20 minutes without chest compressions * At least 1 mg of epinephrine * Coma defined as an inability to obey verbal commands (Glasgow Coma Scale motor response \<6 or Full Outline of UnResponsiveness (FOUR) score motor response \<4) after sustained ROSC * Eligible for intensive care without restrictions or limitations * Inclusion within 90 minutes of ROSC * Age 18 years or older * Next of kin informed about the trial and having consented to participation of the patient in the trial (patients with coma are unable to consent). If no next of kin can be contacted during screening for the study, trial inclusion will be completed as an emergency procedure by the ICU physician, in compliance with Country of inclusion law. * Healthcare costs covered by a healthcare insurance system Exclusion Criteria: * Temperature at admission \<30°C * Obvious or suspected pregnancy * Intracranial bleeding * Dependent on others for activities of daily living before hospitalization * Patient under curators, guardianship or under protection of justice * Correctional facility inmate * Patient who does no speak French

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Conditions

The condition(s) this trial relates to.

cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    31 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHM - Hôpital Nord

    RECRUITING

    Marseille, France, 13015, France

  • APHP - Hôpital Ambroise Paré

    RECRUITING

    Paris, France, 92200, France

  • APHP- Hôpital Cochin

    RECRUITING

    Paris, France, 75679 cedex 14, France

  • APHP-Hôpital Saint-Antoine

    RECRUITING

    Paris, France, 75517, France

  • CH Brocéliande Atlantique

    RECRUITING

    Vannes, France, 56017 cedex 1, France

  • CH Dubois Brive

    RECRUITING

    Brive-la-Gaillarde, France, 19312 cedex, France

  • CH Public du Cotentin

    RECRUITING

    Cherbourg, France, 50102, France

  • CH d'Angoulême

    RECRUITING

    Angoulême, France, 16000, France

  • CH de Roanne

    RECRUITING

    Roanne, France, France

  • CHD Vendée

    RECRUITING

    La Roche-sur-Yon, France, 85025 Cedex, France

  • CHR d'Orléans

    RECRUITING

    Orléans, France, 45100, France

  • CHRU de Strasbourg

    RECRUITING

    Strasbourg, France, 67091 cedex, France

  • CHRU de Tours

    RECRUITING

    Tours, France, 37044 Cedex 9, France

  • CHRU- Hôpital Roger Salengro

    RECRUITING

    Lille, France, 59307 cedex, France

  • CHU Bocage

    RECRUITING

    Dijon, France, 77908, France

  • CHU Charleroi

    RECRUITING

    Charleroi, Belgium

  • CHU Clermont-Ferrand

    RECRUITING

    Clermont-Ferrand, France, 63003 cedex 1, France

  • CHU Dupuytren

    RECRUITING

    Limoges, France, 87042 Cedex 1, France

  • CHU Les Abymes

    RECRUITING

    Pointe-à-Pitre, La Guadeloupe, 97110, Guadeloupe

  • CHU de Caen

    RECRUITING

    Caen, France, 14033, France

  • CHU de Nantes

    RECRUITING

    Nantes, France, France

  • Clinique Saint-PIerre

    RECRUITING

    Ottignies, Belgium, Belgium

  • Hôpital André Mignot

    RECRUITING

    Le Chesnay, France, 78150, France

  • Hôpital Edouard Herriot

    RECRUITING

    Lyon, France, 69437, France

  • Hôpital Erasme

    RECRUITING

    Brussels, Belgium

  • Hôpital Privé Jacques Cartier

    RECRUITING

    Massy, France, 91300, France

  • Hôpital Sainte-Musse

    RECRUITING

    Toulon, France, 83100, France

  • Hôpital Simone Veil

    RECRUITING

    Cannes, France, 06414 cedex, France

  • Hôpital Universitaire de Bruxelles

    RECRUITING

    Jette, Belgium, Belgium

  • Hôpital Universitaire de Gand

    RECRUITING

    Ghent, Belgium, Belgium

  • Hôpital de l'Archet

    RECRUITING

    Nice, France, 06200, France

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Other studies related to the condition(s) this trial covers.