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Could a cheap vitamin shield the aging brain during heart surgery?

NCT ID NCT06326996

Disease control Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study tests whether giving thiamine (vitamin B1) during coronary artery bypass surgery can reduce the memory and thinking problems that sometimes follow the procedure. Older adults with coronary heart disease who are scheduled for bypass surgery and have low thiamine levels may receive either a thiamine infusion or a placebo. Researchers will compare cognitive function, blood markers, and quality of life between the two groups to see if this simple intervention makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Thiamine (Vitamin B1) infusion
What this could lead to
If effective, a low-cost thiamine infusion could help preserve memory and thinking skills in older adults after heart bypass surgery.
What could go wrong
This is a small early-phase trial, so results may not apply broadly. Thiamine is generally safe, but its benefit for cognition is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 52 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with Coronary Heart Disease (CHD) scheduled for Bypass Grafting (CABG) * Thiamine deficiency before CABG * European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) \>1.5% * Off-pump surgery Exclusion Criteria: * Dementia at baseline \[Montreal Cognitive Assessment (MoCA) \<21 within 5 days before CABG\] * Current in-take of thiamine * Known thiamine allergy * Uncontrolled blood glucose levels * Unable to give consent due to illness * History of hyperlactatemia * Recent (within several years and/or up to the judgment of the PI/co-PIs) cerebral incidents (seizure or head trauma resulting in loss of consciousness and/or concussion) * Stroke * Diagnosed psychiatric diseases (clinical depression, schizophrenia, manic-depression) * Patients with history of alcohol or substance abuse * Acute or chronic infections (tuberculosis, hepatitis, or encephalopathy) * Diagnosed neuro-degenerative diseases (Alzheimer's or Parkinson's disease) * Chronic immunodeficiency (including HIV) * Congenital brain deficits will also be excluded

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary artery bypass grafting Coronary heart disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UCLA

    RECRUITING

    Los Angeles, California, 90095, United States

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