University Of California, Los Angeles

This study tests two strategies to help doctors communicate better about the HPV vaccine, which prevents several cancers. About 100,000 children ages 9-13 who haven't had the vaccine yet will take part across up to 72 clinics. The goal is to see if online training or extra team s…

This study is testing whether a probiotic supplement can help adults with obesity lose weight and reduce food addiction. Researchers will look at changes in gut bacteria and metabolism. The study involves 100 adults aged 18-50 with a BMI between 25 and 40. Participants will take …

This pilot study will test whether a hybrid closed-loop insulin pump (a 'smart' pump that adjusts insulin automatically) can help 40 adults with poorly controlled type 1 diabetes (A1c over 8.5%) from diverse backgrounds in Los Angeles. The goal is to see if it's possible to run a…

This study compares two FDA-approved artificial disc implants (Mobi-C and Simplify) used in neck surgery for conditions like herniated discs or pinched nerves. About 20 adults aged 18-60 who haven't improved with non-surgical care will be randomly assigned to receive one of the i…

This study looks at how safe and effective a custom-made stent graft is for treating complex aortic aneurysms (bulging blood vessels near the kidneys or chest). About 50 people at high risk for open surgery will receive the graft. Researchers will track serious complications like…

This study is testing whether a 16-week ketogenic diet (low carbs, high fats, medium protein) is safe and helpful for teens and young adults (ages 12–21) with bipolar disorder who are experiencing depression or mixed episodes. Participants will continue their usual medications wh…

This study tests a new MRI technique that highlights acidic areas around glioblastoma tumors, which may contain cancer cells not visible on standard scans. Surgeons will use this information to remove extra tissue during surgery, aiming to improve survival. The trial includes abo…

This study tests a gene therapy for children with ADA-SCID, a severe immune disorder often called 'bubble boy disease.' The treatment uses the child's own blood stem cells, which are modified in a lab to correct the genetic defect and then returned to the body. The goal is to res…

This study tests a new way to help people with HIV who have stopped taking their medication. Instead of a one-size-fits-all approach, participants can choose which services they receive and how. The goal is to see if this choice helps more people achieve an undetectable viral loa…

This study tests a daily oral supplement designed to boost nitric oxide, a natural chemical that helps blood vessels relax and stay clot-free. As we age, blood vessels can become less efficient, raising the risk of heart disease. The supplement aims to lower levels of PAI-1, a bl…

This study looks at whether taking prebiotics (a type of fiber) can improve gut health in people with ulcerative colitis, a form of inflammatory bowel disease. About 70 adults with active symptoms will take a prebiotic supplement for 8 weeks. Researchers will track changes in sym…

This study looks at 90 stroke patients who need emergency clot removal. It compares two forms of general anesthesia to see which one better maintains blood flow to the brain and improves recovery. The goal is to find the best anesthesia method for future larger trials.

This study tests whether smartphone tools can help people with HIV achieve and maintain viral suppression (low virus levels). It enrolls 1,000 adults who face challenges like substance use, mental health issues, or barriers to care. Participants use their phones to track adherenc…

This study tests whether injecting antibiotics around chronic wounds can help them heal better than standard care alone. About 60 adults with non-healing wounds on their arms, legs, or trunk will either receive the injections plus usual wound care, or usual care only. The study l…

This study tests a support package for people with HIV in Malawi who often miss treatment when they move. It includes counseling, a hotline, and longer medication supplies. Researchers want to see if this approach is acceptable and practical for patients and healthcare workers. T…

This study follows 100 men with prostate cancer who choose to have high-intensity focused ultrasound (HIFU) as their treatment. The goal is to see how well the procedure destroys cancer tissue and how it affects quality of life, including urinary, bowel, and sexual health. Partic…

This early-phase study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop their daily anti-rejection medications. Ten adults with a stable, well-functioning kidney from a matched living donor will receive a conditioning tr…

This study tests a system that uses a special pill sensor to track when HIV medication is taken. If doses are missed, the system alerts a care team who can help with social issues like food or housing that might be getting in the way. The goal is to see if this approach helps 110…

This study is testing a smartphone app with phone coaching to help teens and young adults who are overweight after a stem cell transplant. The goal is to see if the app can help them lose weight and improve their health. The study will include 20 people aged 13 to 30 who are at l…

This study compares two ways to create a connection between an artery and vein (called a fistula) for dialysis in people with end-stage kidney disease. The newer method uses a device through the skin with local anesthesia, while the traditional method requires open surgery and ge…

This study adapts a peer-led program for pregnant and breastfeeding women who drink alcohol. Researchers will test whether trained mentor mothers can help 100 women reduce alcohol use and improve adherence to HIV prevention or treatment medications. The goal is to support healthi…

This study tests whether a drug called ferric citrate can safely lower a hormone linked to heart and bone problems in children with chronic kidney disease. About 160 kids aged 6-18 will take either the drug or a placebo for 12 months. The goal is to see if the drug improves miner…

This study tests whether a one-time infusion of donor stem cells, combined with low-dose radiation and immune therapy, can retrain the immune system to accept a liver transplant without lifelong anti-rejection drugs. The goal is to safely wean 12 adult liver transplant recipients…

This study tests a new treatment for people who have had a stroke caused by a blood clot. A weak electrical current is applied to the scalp to increase blood flow to the brain and protect tissue at risk of damage. The goal is to find the safest and most effective dose. About 120 …

This study looks at whether a calorie-controlled, anti-inflammatory diet combined with walking can reduce heart disease risk factors in men with advanced prostate cancer who are on hormone therapy (ADT). The researchers want to see if African American men respond differently than…

This early study tests the safety of implanting a spinal cord stimulator in people with neck-level spinal cord injuries who rely on ventilators to breathe. The goal is to see if the device can help them breathe more on their own. The study involves 12 adults who are at least one …

This study aims to develop a simple, non-invasive test using light sensors to diagnose myofascial pelvic pain, a condition that affects up to 26% of women. Researchers will test the device on 110 women with chronic pelvic pain to see if it can accurately detect muscle problems wi…

This study tests an online program to help at-risk UCLA students prevent type 2 diabetes. About 80 students with prediabetes or high risk will take part. The program focuses on weight loss and healthy habits, and researchers will see if it works and is easy to use.

This study tests a new way to prevent HIV by giving a long-acting injectable medication called lenacapavir to people who are unhoused or unstably housed in Los Angeles County. A mobile health van brings the shots directly to shelters, encampments, and community centers. The goal …

This study tests a program called MEPS that uses a mobile app, peer mentors, and small rewards to help people recently released from jail get HIV testing, PrEP (a daily pill to prevent HIV), and substance use treatment. About 300 people in California will take part. The goal is t…

This study tests whether giving penicillin to pregnant women at high risk can prevent them from getting syphilis. About 500 women in Rio de Janeiro will receive either the antibiotic or standard care during their third trimester. The goal is to protect both mother and baby from i…

This study tests whether injecting a drug called anakinra into the knee soon after an ACL injury can prevent arthritis from developing years later. About 32 people aged 18 to 35 with a confirmed ACL tear will receive either the drug or a placebo. Researchers will track pain, func…

This study tests whether a special nerve block (QL block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 80 adults having a planned hip replacement will take part. The study will measure pain levels and how quickly patients can stand up a…

This study tests a new way to manage pain after a double lung transplant. Instead of relying only on strong pain medicines, doctors will use a cold-therapy probe during surgery to numb the nerves near the incision. The goal is to see if this method reduces the need for opioids an…

This study compares cognitive behavioral therapy (CBT) to usual care for children aged 6-14 with autism who have emotional dysregulation, such as anxiety or irritability. About 100 children will participate, with their therapists receiving either weekly expert online coaching or …

This study looks at how voice therapy works for people with vocal fold lesions (like nodules). Researchers want to see if specific exercises actually lower the pressure between the vocal folds when they collide. 60 adults aged 18-40 with these lesions will be studied before and a…

This study tests whether a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) can safely increase brain activity in a memory-related area and possibly improve memory. About 144 adults aged 50–90 with mild cognitive impairment or mild Alzheimer's will…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can help reduce both knee arthritis pain and depression in older adults. Thirty volunteers aged 50 and older with chronic knee pain and moderate-to-severe depression will receive rTMS whil…

This study looks at whether Xiidra, an FDA-approved eye drop for dry eye, can help glaucoma patients who have eye discomfort from using multiple eye pressure-lowering medications. About 75 adults who already take glaucoma drops and have dry eye symptoms will receive Xiidra as par…

This study looks at whether treating ongoing sleep problems after PTSD therapy can also improve heart health in older adults. About 167 veterans aged 50 and older with PTSD and insomnia will receive talk therapy for PTSD, followed by a non-drug sleep program if needed. Researcher…

This study tests whether taking vitamin B1 (thiamine) capsules can improve brain function in adults with type 2 diabetes. Many people with diabetes are low in thiamine, which may affect the blood-brain barrier and thinking skills. Researchers will use brain scans, memory tests, a…

This study tests whether a series of online group discussions can help Black American women with breast cancer feel less depressed and less tired. About 90 women will take part in either the online groups or receive materials to use on their own. The goal is to see if sharing exp…

This study tests a program called Reminder-Focused Positive Psychiatry (RFPP) for teens aged 11-15 with PTSD. The program helps teens cope with trauma reminders and aims to reduce PTSD symptoms and improve well-being. Sixty teens will be randomly assigned to either RFPP or a gene…

This study tests a talk therapy called Emotional Awareness and Expression Therapy (EAET) for veterans with long-term muscle or bone pain. About 84 veterans from up to 7 VA hospitals will try EAET to see if it reduces pain and improves mental health. The goal is to find out if thi…

This study tests whether a low dose of buprenorphine (0.15 mg) can improve social motivation in 40 adults with schizophrenia. Social motivation problems—like low desire to connect with others—are common and have no approved treatments. Participants will receive both the drug and …

This study combines psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy (CBT) to treat depression. Researchers want to see if this approach is practical and helpful for 50 adults aged 21-60 with major depression. Participants will receive two d…

This study tests whether the drug cytisinicline can change how the brain reacts to seeing smoking-related images. 64 daily smokers who are not trying to quit will receive either the drug or a placebo and undergo brain scans. The goal is to see if the drug reduces brain activity l…

This study tests whether mild electrical stimulation of the spinal cord can help improve bladder function in men with spinal cord injury. The goal is to increase urine flow and volume, making catheterization easier. The trial involves 24 participants who will attend testing sessi…

This study looks at how to best manage pain in children after surgery for a broken elbow. It compares two pain medicine combinations: one with acetaminophen and ibuprofen (no opioids) and another with acetaminophen and oxycodone (an opioid). The goal is to see if the opioid-free …

This study tests a noninvasive, personalized brain stimulation treatment (TMS) for people aged 18-65 with chronic symptoms after a mild concussion or brain injury, such as headache, dizziness, brain fog, or anxiety. Participants will have a 66% chance of receiving active TMS and …

This study tests a device that uses mild electrical pulses to relax pelvic floor muscles and reduce chronic pelvic pain in women. Researchers want to see if nurses without special training can deliver this treatment as effectively as a doctor. Sixty women with myofascial pelvic p…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in older adults with mild cognitive impairment or subjective memory complaints. About 70 participants will be randomly assigned to receive either …

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can reduce symptoms of borderline personality disorder (BPD). Up to 30 adults with BPD will be randomly assigned to receive either real or sham (placebo) stimulation…

This study looks at whether doing a positive mood exercise before exposure therapy can improve treatment for public speaking anxiety. About 94 adults with social anxiety will take part. They will be randomly assigned to either a positive mood treatment or a relaxation treatment b…

This early-stage study tests whether repeated low-intensity focused ultrasound pulses can safely reduce tremors in people with essential tremor. Twenty adults will receive six treatment sessions over two weeks, with tremor severity measured before and after. The goal is to see if…

This early-stage study tests whether a non-invasive brain stimulation technique called deep rTMS can safely improve memory in people with mild-to-moderate Alzheimer's disease. Researchers will compare active stimulation to a placebo in 54 older adults, using memory tests, brain s…

This study tests a new method to reduce fear in people with phobias (like spiders or snakes) using brain scans and unconscious training. Instead of facing their fears directly, participants get a kind of brain feedback that works without them even noticing. The goal is to lower f…

This study tests whether fun computer-based brain exercises can help young people at high risk for psychosis think more clearly and function better at school, work, or with friends. Fifty-four participants in Tunisia will either do 12 weeks of cognitive training or receive standa…

This study is testing a smartphone app designed to help teenagers with obesity lose weight. The app is based on the idea that replacing unhealthy coping behaviors with healthy ones can stop overeating. Researchers will enroll 38 teens aged 14-21 to see if the app is easy to use a…

This study compares a 6-week mindfulness program to a sleep education class to see which better improves sleep in first- and second-year college students. About 240 UCLA students aged 18-22 who have trouble sleeping will participate. Researchers will track sleep quality, inflamma…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve both depression and chronic pain symptoms. Fifty-four adults with moderate depression and pain will receive 30 sessions of active treatment, along with surveys, blood draws, MRIs, and EEGs…

This study tests whether cannabidiol (CBD), a compound from cannabis, can help people who want to quit smoking reduce their cigarette use. About 120 adults with tobacco use disorder will receive either CBD or a placebo twice daily for 56 days. Researchers will measure nicotine le…

This study tests a sleep improvement program designed specifically for older Korean immigrants who have trouble sleeping. The program adapts standard sleep therapy to fit Korean culture and language. Researchers will work with 32 volunteers aged 60 and older to see if the program…

This study looks at whether a program called Help Texts, which sends weekly supportive messages about grief and coping, can reduce sadness and help college students who have lost a loved one. About 126 UCLA students who lost someone close in the past year will either get the text…

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study tests a 6-week mindfulness program designed to reduce stress, depression, and burnout in 80 healthcare workers from UCLA Health. Participants will learn practices like loving-kindness and compassion to improve well-being and reduce inflammation. The goal is to see if t…

This study looks at whether giving children a nerve block in the arm before elbow fracture surgery helps control pain afterward. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either the nerve block or standard care. Researchers will…

This study compares remote training (telerehabilitation) to in-person visits for teaching people with low vision how to use magnifiers and visual apps for daily tasks like reading. It also tests whether Bluetooth sensors can detect when patients stop using their devices, so help …

This study tests whether a faster, personalized version of brain stimulation (rTMS) is safe and practical for people hospitalized with severe depression. Thirty adults who haven't improved with standard treatments will receive up to 25 sessions over two weeks, with the stimulatio…

This study tests a non-invasive technique called focused ultrasound to stimulate a deep brain region (the thalamus) in people who have been in a coma or minimally conscious state for over a month after a severe brain injury. The goal is to see if this can safely improve their lev…

This study compares two proven emergency care methods for teens and young adults (ages 13-24) who come to the ER with suicidal thoughts or actions. The goal is to see which approach better prevents suicide attempts and helps them start mental health treatment. Researchers will fo…

This study tests whether a special belt with laser lights can reduce long-term back pain in people who had spinal fusion or decompression surgery. About 80 adults who have had back pain for over 3 months after surgery will wear either a laser belt or a normal brace. Researchers w…

This study looks at two ways to decide the best treatment for anxiety and depression in 1,000 community college students. Participants will be placed into one of three care levels: self-guided online help, coach-guided online therapy, or care from a clinician. The goal is to see …

This study tests a new virtual reality training designed to help people with depression and low positive affect feel more joy and pleasure. 80 adults will be randomly assigned to either the VR reward training or a memory training control group for 7 weeks. The goal is to see if t…

This pilot study tests whether drinking one cup of pomegranate juice daily for 8 weeks can lower gut inflammation and improve quality of life in 30 adults with mild-to-moderate ulcerative colitis. Researchers will also check how the juice affects gut bacteria. Participants must f…

This study tests whether adding a home-based telerehabilitation program to usual care helps people with arm weakness after a stroke. About 202 participants who had a stroke 90-150 days ago will be randomly assigned to either receive telerehabilitation plus usual care or usual car…

This study tests a procedure called hemorrhoidal artery embolization (HAE) for people with internal hemorrhoids who have not had success with other treatments or cannot have surgery. HAE blocks the blood supply to the hemorrhoid tissue to reduce symptoms, especially bleeding. Abo…

This study looks at whether small changes to the electronic health record system can help doctors prescribe fewer unnecessary acid-reducing pills (PPIs). The study involves 372 UCLA Health primary care doctors. The goal is to see if changing the default prescription length from 9…

This study looks at whether thinking about a supportive person can help people with social anxiety disorder feel less fear. Researchers will show pictures of a loved one or a stranger while giving mild electric shocks to see if the loved one's image reduces fear. The goal is to u…

This study looks at whether wearing a continuous glucose monitor (CGM) for just 24 hours after giving birth can help predict a woman's long-term risk of developing type 2 diabetes. About 50 women who had gestational diabetes will wear the sensor and complete surveys. The goal is …

This study looks at how writing about your experiences can change your brain and body. Healthy adults aged 65 and older will write once a week for 6 weeks and complete online surveys. Participants also visit UCLA twice for a brain scan (fMRI), a blood sample, and more questionnai…

This study looks at whether cannabis works differently for pain relief and carries different abuse risks in men versus women. Researchers will give cannabis to 160 people aged 21-55 who already use it 1-7 days a week. They will measure pain tolerance, drug effects, and blood leve…

This study compares two web-based apps to see which one better helps Latinas with anxiety or depression start mental health treatment. One app uses an interactive story with a character who gives treatment advice, while the other provides standard information and resources. The g…

This study looks at 140 infants (6-8 months old) who have an older sibling with autism, putting them at higher risk. Researchers want to find out whether starting a parent coaching program at 9, 12, or 15 months leads to the best language and communication skills by age 2. Famili…

This study looks at how smoking high-potency cannabis changes pain perception and feelings of a 'good drug effect' in people who use cannabis nearly every day. Researchers will also measure how long THC stays in the blood. The goal is to understand these effects both during norma…

This study aims to develop algorithms that can help people with paralysis move again using assistive devices like robotic arms or wheelchairs. Researchers will record brain and muscle signals from 50 healthy volunteers as they perform, imagine, or attempt movements. The goal is t…

This study looks at a hormone called secretin in teenagers with anorexia who are being fed in the hospital. Some of them urinate a lot, which can delay their recovery. Researchers want to see if secretin levels differ between those who urinate excessively and those who don't. Par…

This study looks at whether sinus surgery improves lung function and quality of life in adults with cystic fibrosis who also have chronic sinusitis. Researchers will compare people who have surgery with those who only receive medical treatment. The goal is to understand the real-…

This study tests a new AI model that predicts which patients with chronic diseases will have the highest medical costs. The top 500 patients each month are randomly split into two groups: 250 are offered a personalized care management program, and 250 are placed on a waitlist. Re…

This study tests a new system to classify placenta accreta during surgery, aiming to improve surgical planning and outcomes. About 60 pregnant people at risk for this condition will have their ultrasounds and surgical findings compared. The goal is to see if this classification h…

This study explores whether artificial intelligence can simplify the complex language used in clinical trial consent forms. Researchers will test AI-generated simplified versions with 230 participants, including older adults, doctors, and ethics board members. The goal is to see …

This study tests two programs in public schools: one helps educators use proven techniques to reduce challenging behaviors in autistic children, and the other helps school leaders keep these techniques in use over time. About 373 teachers and students in grades K-5 will take part…

This study looks at how age and sex change the way people react to THC, the main active ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who already use cannabis weekly or monthly. They will measure pain relief, feelings of being high, an…

This study looks at how memories are strengthened during sleep by recording brain activity in people with epilepsy. Researchers will use sounds and mild electrical pulses during sleep to see if they can improve memory. The goal is to understand memory processes better, not to tre…

This study looks at whether seeing a picture of a supportive person can help people with social anxiety unlearn fear. Researchers will compare how healthy volunteers and those with social anxiety respond to fear cues paired with either a support figure's image or a stranger's smi…

This study aims to create a checklist of signs and symptoms that can reliably tell doctors when a CT scan is not needed after a blunt injury (like a car crash). By studying 12,000 emergency room patients, researchers hope to reduce unnecessary scans, which expose people to radiat…

This study tests whether a program called TransAction helps transgender women in Ho Chi Minh City improve their HIV prevention and care. Participants will attend individual counseling, skill-building groups, and social events. The goal is to see if this approach helps more people…

This study looks at how modern cystic fibrosis medicines affect sinus disease and sense of smell in children ages 2 to 8. Researchers will use MRI scans, smell tests, and quality-of-life surveys over two years. The goal is to understand if these treatments help improve sinus and …

This study looks at why people with alcohol use disorder feel motivated to drink. Researchers will ask 210 adults aged 21-65 about their mood, habits, and thinking, then give them alcohol through an IV and see how hard they press a button for more. The goal is to understand the r…

This study follows 80 youth aged 9-19 with bipolar disorder to learn what affects their mood over time. Researchers will track symptoms, inflammation, and family relationships. The goal is to improve diagnosis and treatment for young people with this condition.

This study looks at whether using surgical mesh during breast reconstruction after mastectomy is safe and helpful. About 120 women will be randomly assigned to get reconstruction with or without mesh. The goal is to compare complication rates and patient satisfaction to guide fut…

This study tests whether a program that pairs people in the ER with a trained peer recovery specialist helps them connect to addiction treatment and support services. Researchers will follow 400 adults who came to the ER for a substance use-related issue, comparing those who get …

This study tests whether artificial intelligence can create easy-to-understand summaries of eye doctor notes. About 460 adults receiving eye care will get either the usual medical notes or notes with an AI-generated plain language summary added. Participants will answer surveys r…

This study looks at whether brain scans can help predict which people with chronic low back pain will get good pain relief from spinal cord stimulation (SCS). Researchers will scan the brains of 42 adults before they receive SCS as part of their normal care, then check their pain…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the part that makes you high). Researchers will give both substances to 30 regular cannabis users (ages 21-55) who are not seeking treatment. They will measure drug effects, pain relief…

This study looks at whether telling patients to arrive 15 minutes before their appointment helps them show up on time. Researchers will compare this to just asking patients to come early without a specific time. The goal is to improve clinic flow and make visits smoother for ever…

This study collects information from people with ASXL-related disorders (such as Bohring-Opitz syndrome) to learn how these conditions progress and are managed. Researchers will use surveys and medical records to gather data. The goal is to improve treatment and care for these ra…

This study follows 250 adults in the intensive care unit (ICU) to learn why some become frail and lose muscle. Researchers will track hospital stays, falls, and readmissions to find factors that can be changed. The goal is to identify targets for future treatments to help patient…

This study looks at high-achieving Black, Latinx, and Asian American high school students who succeed despite stress. Researchers want to see if mindfulness training can reduce the physical and mental health problems that often come with this kind of resilience. About 504 student…

This study looks at how spinal cord stimulators affect the brains of 20 adults with chronic low back pain. Researchers will use fMRI scans to compare brain activity when the stimulator is on versus off. The goal is to find patterns that predict who will benefit most from this tre…

This study looks at how brain activity syncs up between two people during social interactions, aiming to understand why social connection is harder for those with schizophrenia. About 100 participants—half with schizophrenia and half without—will have their brain waves recorded w…

This study looks at how gut bacteria and diet relate to irritable bowel syndrome (IBS). Researchers will measure substances in stool from people with IBS and healthy volunteers after a special diet. The goal is to understand what causes IBS symptoms, not to test a treatment. Abou…