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Brain games for psychosis prevention: a new hope?

NCT ID NCT06582901

Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether computer-based cognitive training, combined with group therapy, can improve thinking skills and daily functioning in Tunisian youth at clinical high risk for psychosis. Fifty-four participants will either receive the cognitive training program or an enhanced usual care group. The goal is to see if this approach is feasible and helps reduce the chance of developing psychosis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive training (computer-based brain exercises) plus group therapy
What this could lead to
If it works, this could point toward a non-drug way to help young people at risk of psychosis think more clearly and function better in daily life.
What could go wrong
This is a small, early feasibility study with only 54 participants, so results may not apply broadly. The intervention is time-intensive and may not show clear benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2023

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 28 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meets Comprehensive Assessment for At Risk Mental States (CAARMS) criteria for Clinical High Risk * If under the age of 18, the subject has a parent or guardian who can sign consent forms * Premorbid Intelligence Quotient not less than 70 * Sufficient fluency in Arabic, French, or English to avoid invalidating research measures * Residence likely within commuting distance of Razi University Hospital Exclusion Criteria: * Evidence of known neurological disorder, e.g. epilepsy or significant head injury that could account for the CHR symptoms * Evidence of significant and habitual alcohol or substance use in the 6 months prior to study entry * Evidence that the clinical high-risk symptoms were substance-induced

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Conditions

The condition(s) this trial relates to.

psychotic disorder prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Clinical high risk for psychosis (CHR)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Razi University Hospital

    RECRUITING

    Tunis, Tunisia

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