University Of California, Los Angeles

This early-phase study tests whether the drug belumosudil can help people who get a kidney transplant along with a stem cell transplant from the same donor. The goal is to see if it is safe and allows patients to stop taking most anti-rejection drugs over time. Sixteen adults wit…

This study aims to improve blood pressure control among a diverse group of patients in Los Angeles County. Researchers will compare three approaches: training healthcare providers, educating patients with culturally tailored materials, and usual care. About 540 adults with high b…

This study planned to test a drug called Increlex (a growth factor) in children aged 4 to 18 with chronic liver disease and short stature. The goal was to see if it could help them grow better and improve their quality of life. However, the study was withdrawn before any particip…

This study tests a family-focused therapy program for 220 youth aged 13-25 who show early signs of psychosis risk. The therapy aims to reduce troubling symptoms and lower the chance of developing full psychosis over 18 months. Participants attend therapy sessions with a parent or…

This early-phase study tests whether a person's own stem cells can be safely grown in a lab and transplanted onto the eye to repair a damaged cornea. The trial involves 20 adults with limbal stem cell deficiency, a condition that causes vision loss. The main goals are to see if t…

This study looks at whether giving testosterone to men with low testosterone and kidney failure before a kidney transplant can help them recover better and more safely. About 50 men will receive testosterone for at least 3 months before their transplant, and their outcomes will b…

This study provides fenfluramine to people with Dravet syndrome whose seizures are not controlled by other medications. The goal is to make the drug available and check its safety. Participants must have a genetic diagnosis and have tried all standard seizure drugs.

This study tests whether mobile phone self-monitoring and feedback can help people reduce risky drug use over 12 months. About 458 adults from community health centers in Southern California will be split into three groups: one gets mobile tools plus brief counseling, one gets co…

This study looks at whether offering financial rewards helps hospitalized smokers quit. Over 1,000 participants will be assigned to different incentive programs to see which works best. The goal is to find effective, affordable ways to help people stop smoking for good.

This study looks at whether a tool called endobronchial ultrasound (EBUS) can help diagnose dangerous blood clots in the lungs (pulmonary embolism) in critically ill patients. These patients are often too sick to move for a standard CT scan. The study will enroll 60 adults in the…

This study enrolls 650 HIV-negative pregnant and breastfeeding women in South Africa who are at high risk of getting HIV. Researchers are testing a program that combines daily PrEP pills with extra counseling and community delivery for those who struggle to take the pills regular…

This study tests a handheld device that detects early signs of skin damage up to 10 days before bedsores appear. Nursing home staff will use the scanner during routine checks to decide when to start preventive care. The goal is to prevent painful pressure injuries, especially in …

This study tests whether a mobile app called LifeSkills Mobile can help young transgender women (ages 16-29) reduce their risk of getting HIV. About 5,100 participants across the U.S. will use the app or receive standard care. The main goal is to see if the app lowers new HIV inf…

This study tests whether giving a drug called angiotensin 2 during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 30 adults with end-stage liver disease will be randomly assigned to receive either the drug plus standard care, or…

This study tests a program to help more older adults on Medicare get their annual wellness visit. The program will be rolled out in 24 primary care clinics across the U.S. Researchers hope that by making these visits easier, more people will receive important preventive services …

This study tests a program called the 3 Wishes Project in safety-net hospitals, which serve diverse and disadvantaged patients. The program helps fulfill small, meaningful wishes for dying patients—like playing favorite music or connecting with loved ones—to improve their final m…

This study aimed to see if a daily curcumin supplement could improve memory and attention in adults aged 50-85 with age-related memory complaints. Participants would have taken curcumin or a placebo for up to 12 months and taken memory tests. However, the study was withdrawn befo…

This small study looks at whether a special flashed light therapy, used alone and then with online counseling, is acceptable and tolerable for teens aged 14–17 with ADHD and delayed sleep timing. Only 6 participants are enrolled to test feasibility, not effectiveness. The goal is…

This study looks at whether adding a speech-focused therapy (PROMPT) to a play-based therapy (JASPER) helps minimally verbal children with autism speak more words and combine them into phrases. Fifty-six children aged 3.5 to 5.5 years who use fewer than 20 words will receive eith…

This pilot study tests if a gentle, non-invasive brain stimulation method called TMS can help people with borderline personality disorder (BPD) better manage emotions and impulsivity. Up to 20 participants will receive MRI scans, up to 3 TMS sessions, and computer tests over 3 we…

This early-phase study looks at whether cannabigerol (CBG), a compound found in cannabis, can help with pain and appetite when taken alone or with THC. About 20 healthy adults who use cannabis occasionally will take part. Researchers will measure pain tolerance, hunger levels, an…

This study looks at whether adding a low dose of Adderall XR (a stimulant) to repetitive transcranial magnetic stimulation (rTMS) can better ease depression symptoms. About 30 adults with hard-to-treat depression will be randomly assigned to receive either Adderall or a placebo p…

This study tests a home-based, video-guided exercise platform for people with diabetic foot ulcers. The goal is to see if these exercises can improve blood flow and muscle activity to help wounds heal faster. About 15 adults with diabetic foot ulcers will participate, using a tab…

This study looks at whether a single 25 mg dose of psilocybin (the active ingredient in magic mushrooms) can be safely given to people with cocaine use disorder who want to quit. Ten adults from Los Angeles will take the drug in a comfortable room with two clinicians present, and…

This study tests whether a six-session biofeedback program can help adults aged 18-60 who still have breathing problems like shortness of breath even after seeing a lung specialist and trying standard treatments like inhalers. Biofeedback teaches people to control things like hea…

This study planned to test whether virtual reality guided mindfulness meditation could help adults with anxiety, depression, stress, and pain. Participants would have used a VR headset to meditate, and researchers would measure changes in their symptoms. However, the study was wi…

This study tests a type of brain stimulation called intermittent theta burst stimulation (iTBS) for people with major depression. It involves 30 adults who are already on stable antidepressant medication but still have significant symptoms. The goal is to see if iTBS can further …

This pilot study explores whether using a personalized frequency for repetitive transcranial magnetic stimulation (TMS) can safely and effectively ease symptoms in adults with severe major depressive disorder who haven't improved with multiple medications or therapy. Ten particip…

This pilot study tests whether a fast form of brain stimulation, called accelerated continuous theta-burst stimulation (acTBS), can safely reduce suicidal thoughts in adults hospitalized for suicidality. Forty participants with major depressive disorder will receive either real o…

This study gave pure CBD to 25 children aged 1-17 with severe epilepsy that didn't improve with other treatments. Parents kept seizure diaries to track changes before and after starting CBD, which was added to their current medications. The goal was to see if CBD could help reduc…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can safely reduce fatigue, brain fog, and other neuropsychiatric symptoms in people with Long-COVID. Ten adults with confirmed Long-COVID will receive either real or sham rTMS for 15 sessi…

This study tests a personalized, two-stage therapy approach for minimally verbal preschoolers with autism (ages 3-5) who use fewer than 20 words. Researchers will adjust the type and intensity of therapy based on each child's progress, aiming to improve spontaneous communication.…

This study tests a new therapy called Emotional Resolution (EmRes) to see if it can reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or practice mindfulness-based gratitude. The goal is to find a simple, effe…

This study tests whether a personalized digital app, paired with an electronic toothbrush, helps adults brush twice daily for two minutes. 230 participants from California dental clinics will use the app for 19 weeks. The goal is to see if digital coaching improves brushing habit…

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It works by injecting tiny beads into blood vessels that feed inflamed parts of the knee, reducing blood flow and inflammation. About 100 people with moderate to severe knee pain…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study is testing whether magnesium L-threonate, a form of magnesium that can reach the brain, improves sleep, recovery, and athletic performance in 100 UCLA varsity athletes aged 18-35. Participants take either the supplement or a placebo nightly for 4 weeks while wearing a …

This study looks at whether adding a steroid to a nerve block can provide longer pain relief and reduce the need for strong painkillers after a procedure to treat uterine fibroids or adenomyosis. About 28 women aged 30-60 will be randomly assigned to receive the nerve block with …

This early-phase study tests whether combining spinal cord stimulation with a drug can improve arm and hand movement in people with cervical spinal cord injury. About 12 participants will receive the treatment and have their motor function assessed. The goal is to enable better u…

This study tests a toolkit designed to help primary care practices increase the use of Medicare Annual Wellness Visits, which are check-ups focused on prevention. Over 13,000 patients aged 50 and older with Medicare will take part across 16 practices. The goal is to see if the to…

This study aimed to compare two FDA-approved devices used to seal the artery after a heart catheterization procedure. The goal was to see if using both devices together could shorten the time patients need to lie flat and recover. However, the study was withdrawn before enrolling…

This study aims to understand why some people with Parkinson's disease suddenly freeze while walking. Researchers will record brain activity from implanted deep brain stimulation devices as participants walk in virtual reality. The goal is to identify brain signals linked to free…

This study tests a brain implant, already approved for epilepsy, in 5 blind volunteers to see if stimulating the visual cortex can create visual sensations. The goal is to learn where to place the device and how much stimulation is needed to produce artificial vision. This early …

This study collects data from 10,000 people worldwide who are having a procedure called catheter ablation for fast or irregular heartbeats (ventricular tachycardia or PVCs). The goal is to track how well the procedure works and any complications over time. No new treatment is bei…

This study looks at whether a ketogenic diet (high fat, low carbs) is safe and possible for children in the ICU with sudden brain injuries like stroke or head trauma. The diet aims to provide an alternative fuel for the brain when it can't use sugar well. Researchers will check f…

This study looks at whether giving parents of young children $500 each month for 18 months can improve their family's financial security, reduce stress, and help their kids grow and develop better. About 600 parents in Pomona, California, are taking part, with some receiving the …

This study was designed to test if a non-invasive blood pressure monitor could measure how well the heart is pumping in people with a pulmonary embolism (a blood clot in the lungs). The goal was to see if these measurements could help doctors predict which patients are at risk of…

This study looks at whether adding memory drills to standard treatment helps veterans remember to do things later. About 75 veterans in an intensive program will either get usual care or usual care plus memory drills. Their memory will be tested at the start, end, and 3 months af…

This study looks at how the brain helps people with Parkinson's disease move more easily when they get certain cues, like visual or sound signals. Researchers will record brain activity during deep brain stimulation (DBS) surgery in 40 participants. The goal is to find brain sign…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and a national veterans' population, using both clinical data and molecular markers. The goal…

This study looks at whether a new training module helps medical students learn to talk to patients about firearm safety. About 360 students from UCLA will take part. Researchers will compare students who received the training with those who did not, using a simulated patient exam…

This early-phase study looks at whether terpenes—aromatic compounds found in plants—can reduce pain and how they interact with THC. About 45 adults who use cannabis regularly will take part. The goal is to measure pain relief and any drug-like effects, helping to understand if te…

This study looks at whether daily breathing exercises (called inspiratory muscle training) can improve mental and physical well-being in healthy adults. About 150 participants will be split into three groups: one does stronger breathing exercises, one does very light exercises, a…

This study looks at how breathing in secondhand hookah smoke or e-hookah vapor affects blood vessel health. Healthy non-smokers aged 21-49 will have their blood flow and artery stiffness measured before and after brief exposure to hookah smoke, e-hookah aerosol, or clean air. The…

This study looks at how people learn fear and safety by using virtual reality. Researchers will measure brain activity, heart rate, and sweat responses in 70 adults who already have a brain implant for epilepsy. The goal is to better understand anxiety and PTSD, which could lead …

This study looks at whether an artificial intelligence (AI) tool can make it easier for doctors to review patient charts before a visit. About 284 doctors at UCLA Health will either use the AI tool or continue their usual routine for 90 days. The goal is to see if the tool reduce…

This study aims to develop a more personalized way to treat major depression using repetitive transcranial magnetic stimulation (rTMS). Researchers will identify each participant's unique 'resonant frequency'—the stimulation frequency that best engages brain circuits—and compare …

This early-phase study at UCLA examines whether naltrexone, a drug that blocks opioid receptors, can stop reminders of social support figures from helping people overcome fear. Sixty healthy adults aged 18-35 will undergo a fear conditioning procedure with mild electric shocks, t…

This study follows 70 people who previously received gene therapy for a rare immune disorder called ADA-SCID. Researchers will track their health, survival, and any side effects over many years. No new treatment is given—this is purely an observation to see how well the gene ther…

This study aimed to see if a non-invasive device (ClearSight) can accurately measure how well the heart pumps blood in people with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Researchers planned to compare these readings with st…

This study was designed to see if a program called PCIP could help teens with PTSD in primary care settings, and whether it could be delivered via telehealth. It planned to enroll 44 teens and their caregivers to measure changes in PTSD knowledge, symptoms, and coping skills. How…

This study looks at how a single dose of the antidepressant citalopram, given through an IV, affects brain activity when combined with a type of brain stimulation called theta burst stimulation (TBS). Thirty adults with major depression who haven't gotten better with other treatm…

This study will check how well the HPV vaccine works in women living with HIV and find better ways to screen for cervical cancer. About 650 women will use a self-testing kit at home, and those with positive results will get further exams. The goal is to improve health outcomes fo…

This study tests a new tool that personalizes lab results for adults aged 65 and older with chronic kidney disease. The goal is to see if the new reports help patients better understand their health and feel less anxious. Researchers will compare the new reports to the standard o…

This study looks at how certain cues, like visual or auditory signals, help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to …

This study creates a registry of people who have recovered from COVID-19 and are willing to take part in future research. The goal is to have a ready pool of volunteers for studies on immune response, vaccine development, and blood plasma donation. Over 5,000 participants have al…

This study tests whether a community-based intergenerational mentoring program called Generation Xchange (GenX) can improve antiviral resistance in older African-American adults. Researchers will measure immune responses and track respiratory infections like colds, flu, and COVID…

This study aimed to see if breathing in nitric oxide gas could improve blood flow in the lungs of people with a serious pulmonary embolism (a blood clot in the lung). It planned to include 20 adults at one hospital, measuring heart and lung pressures before, during, and after the…