University Of California, Los Angeles

This study tests whether a sodium lactate infusion is safe for people with severe traumatic brain injury in the intensive care unit. Researchers will monitor for side effects and measure biological markers. The trial involves 264 adults aged 18-80 with a low score on a brain func…

This study looks at whether treating enlarged veins in the stomach (gastric varices) early, before they bleed, is better than waiting and using standard medicines. About 68 adults with liver cirrhosis and gastric varices will either get a procedure called RTO or continue with cur…

This study tests whether trained peer navigators can help people living with HIV who also use substances stay connected to medical care and achieve viral suppression. Researchers will enroll 250 participants in Los Angeles County and track their HIV viral load, clinic attendance,…

This study tests a new, energy-packed therapeutic food (LO-RUTF) against the standard version in 125 children aged 6-59 months with severe acute malnutrition. The goal is to see if the new food helps kids recover faster and improves their brain development. Children will receive …

This study looks at whether sodium bicarbonate, a low-cost medicine, can work as well as potassium citrate to prevent kidney stones. About 30 adults with a history of kidney stones and low citrate levels will take sodium bicarbonate for a short time. Researchers will measure chan…

This study compares a new pain medicine called Suzetrigine to standard opioid painkillers for people recovering from ACL knee surgery. The goal is to see if Suzetrigine can provide similar pain relief while reducing the need for opioids and their side effects. About 140 participa…

This pilot study tests whether a non-invasive brain stimulation technique called rTMS can help reduce symptoms of anorexia nervosa in 45 people aged 14 to 24. Participants will receive 20 daily sessions of rTMS, which uses magnets to stimulate the brain, and will complete surveys…

This study looks at whether drinking a cup of watermelon juice each day for 4 weeks can help improve blood pressure, artery flexibility, and blood sugar in postmenopausal women who are overweight and have slightly high blood pressure. It also tests if the juice boosts the body's …

This study looks at whether the seizure drug brivaracetam can calm overactive brain activity in people with mild Alzheimer's or mild cognitive impairment. Researchers will place tiny electrodes in the brain to measure abnormal electrical signals. The goal is to see if reducing th…

This study tests a non-invasive device that uses mild electrical pulses to strengthen pelvic floor muscles in men who have urine leakage after prostate removal. The goal is to see if it is comfortable and works better than standard exercises. About 37 men who have had or will hav…

This study will test whether psilocybin (the active ingredient in magic mushrooms) combined with cognitive behavioral therapy in a group setting is acceptable and feasible for people with major depression. Thirty adults aged 21-60 with current depressive symptoms will participate…

This study looks at how oral THC and CBD are processed by the body and how they affect thinking and feelings. Researchers will measure drug levels in blood and saliva, and test performance on a smartphone app. The goal is to better understand these substances in people who use ca…

This study looks at whether adding a simple 'very low risk' label to lab results helps adults 65 and older better understand their chance of developing diabetes. About 1,200 participants will get either standard messages or enhanced ones with machine-learning risk info. Researche…

This study looks at whether data from phones and smartwatches can help predict how well treatment for depression during and after pregnancy works. About 250 women in their last trimester or first 12 weeks after giving birth will receive standard therapy and wear devices for 4 wee…

This study looks at how short-term inflammation changes mood and alcohol cravings in people with alcohol use disorder (AUD) compared to healthy volunteers. Researchers will give a low dose of a substance that causes temporary inflammation or a placebo to 64 adults. Participants w…

This study aims to understand why cognitive-behavioral therapy (CBT) helps people reduce repetitive negative thinking, a common issue in anxiety and depression. Researchers will track 500 adults over 16 weeks to see which parts of CBT are most effective. The goal is to improve fu…

This study tests whether a lightweight headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, like coma, after severe brain injury. The goal is to see if this tool can safely detect brain responses to sounds, touch, and m…