Watermelon juice: the new Heart-Health super drink?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female * Generally healthy * Postmenopausal * BMI 25-40 kg/m2 * Systolic blood pressure 120-139 mmHg and/or diastolic 80-89 mmHg * Fitzpatrick Skin type II-IV * Consume a typical Western diet (low in polyphenol/lycopene-rich foods and fiber) * Willing to maintain habitual dietary and exercise patterns for the study duration * Willing to maintain normal skin care products and pattern for the duration of the study * Willing to come to Baseline Visit B and Week 4 study visits without any makeup and skin products on * Subjects must read and sign the Institutional Review Board-approved written informed consent prior to the initiation of any study specific procedures or enrollment. A subject will be excluded for any condition that might compromise the ability to give truly informed consent. Exclusion Criteria: * Non-English speaker * Vegetarian/vegan * Known watermelon allergy * Skin-related prescription medication, supplements, or non-prescription cosmeceutical agents * Initiation of topical or oral prescription steroids and/or anti-inflammatory medications within 30 days prior to study enrollment * Excessive exposure to either natural or artificial sunlight. Exposure to sunlight will be evaluated using Fitzpatrick Skin Type test score. Individuals receiving scores higher than the upper cutoff of the proposed range for the specific skin type will be excluded * Screening laboratory values outside of the normal range that is considered clinically significant for study participation by the investigator * Documented chronic disease, including diabetes, renal or liver diseases, metabolic syndrome, active cancer, MI or stroke, history of gastric bypass or GI disease (e.g., Crohn's disease, IBD, diverticulosis, diverticulitis, etc.) * Taking medications or supplements known to affect metabolism or gut microbiota composition (antibiotics within the past 3 months, probiotics, fiber, etc.), unless willing to stop for the study duration * Taking exogenous hormones (e.g., hormone replacement therapy) * Recent weight fluctuations (\>10% in the last 6 months) * Smoker or living with a smoker * Use of \>20 g of alcohol per day * Unable or unwilling to comply with the study protocol (including unwillingness to avoid watermelon and other lycopene-rich foods for the whole duration of the study) * Unable to provide consent