Sound wave therapy aims to spark memory in early Alzheimer's

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Amnestic MCI or Mild Alzheimer's diagnosis * Age 50-90 * English-speaking * Ability to provide informed consent * Normal or corrected-to-normal hearing and vision Exclusion Criteria GENERAL * Participation in another clinical trial * Active use of immunotherapeutic medications for cognition (Aduhelm, Leqembi, Kisunla) * Moderate to Severe Alzheimer's * Inability to provide informed consent MRI-Related: * Weight exceeding 275 pounds * Pregnancy, suspicion of pregnancy, or attempting to become pregnant * Claustrophobia * Difficulties during previous MRIs * Top permanent retainer (bottom only is okay), 5 or more non-removable gold-teeth, metal braces, top spacers, and/or palate expanders * Any of the following implants: Cardiac Pacemaker, Aneurysm clips, Cochlear implants, Defibrillator, Electrodes or wires, Magnetically-activated device, Spinal cord stimulator, Infusion or insulin pumps, Implanted drug infusion device, Deep brain stimulation device * Non-removable hairpieces, hairpiece extensions, and/or piercings * Facial tattoos or permanent makeup * Metal implants that are MR-incompatible, or where participant is unable to provide sufficient information to determine MR compatibility * Previous injury by metallic foreign body (e.g., bullet, BB, shrapnel) where the object entered the body and participant lacks doctor's confirmation that it was fully removed Medical: * Diagnosis of one or more of the following neurological disorders: Parkinson's disease, Lou Gehrig's disease (ALS), Multiple sclerosis, Cerebral Palsy * Diagnosis of one or more of the following genetic disorders: Cystic Fibrosis, Sickle Cell Disease * Diagnosis of one or more of the following psychiatric disorders: Bipolar, Psychosis * Psychiatric illness that has not been controlled for at least two months (if controlled \>2 months, with or without medication, they are not exclusionary) * Severe lung, liver, heart, and/or kidney disease/s (e.g., heart failure, liver failure, and etc...) * Diagnosis of thyroid disorder or change of thyroid medication dose within the last 3 months * Cancer treatment/s with chemotherapy and/or radiation to head and neck, or stage 4 (metastatic) cancer * Autoimmune disorder or viral infection such as HIV, COVID 19, or hepatitis C that has caused current problems with cognition/memory * History of substance abuse in the past year * History of stroke (Transient ischemic attack / mini-stroke not exclusionary if symptoms lasted \<1 week) * History of 2 or more seizures or diagnosis of epilepsy, unless the seizures occurred prior to age 5 alongside a fever. * History of brain tumor, brain aneurysm, brain hemorrhage, or subdural hematoma (transient ischemic attack not exclusionary) * Head injury that resulted in loss of consciousness lasting \>30 minutes, cognitive issues lasting \>18 months, and/or brain abnormalities visible in CT or MRI scan * Uncontrolled high blood pressure or diabetes * Heart attack within the last year