MILD COGNITIVE IMPAIRMENT

This study compares two diets—a low-carb (ketogenic) diet and a low-fat diet—in 120 adults with mild cognitive impairment (early memory loss). Participants follow their assigned diet for 16 weeks, then return to normal eating. Researchers measure changes in thinking skills, brain…

This study tests a 12-week program for people with mild cognitive impairment (early memory loss) and their main caregivers. The program includes professional-led sessions and caregiver support. Researchers will measure changes in thinking, memory, quality of life, and physical he…

This early-stage study tests a drug called CpG 1018 that aims to stimulate the immune system in people with mild cognitive impairment or mild Alzheimer's dementia. The main goal is to check the drug's safety and tolerability at three different dose levels. The study involves 39 p…

This early-stage trial tests a gene therapy that delivers a protein called BDNF directly into the brain. The goal is to slow or prevent brain cell loss in people with early Alzheimer's or mild cognitive impairment. The study involves 12 participants and focuses on safety and memo…

This study tests whether a daily supplement called Sabroxy® (made from the Oroxylum indicum tree bark) can improve insulin resistance and memory in 140 adults aged 40-80 with mild cognitive impairment and insulin resistance. Participants take either the supplement or a placebo fo…

This study looks at whether a heart procedure called catheter ablation can slow or improve memory loss in people with mild cognitive impairment and persistent atrial fibrillation (an irregular heartbeat). About 120 adults aged 60-80 will be randomly assigned to either medication …

This study tests whether a smartphone app with reminders and education can help older adults (60+) with mild memory problems stick to their blood pressure medication routine. About 100 participants will use the app or receive standard education for 16 weeks. The goal is to see if…

This study tests an experimental drug, senicapoc, in people with mild or early Alzheimer's disease. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks. This is an early-phase …

This study tests a weekly injection called mazdutide in 420 people with type 2 diabetes who also have mild memory problems or early dementia. The goal is to see if the drug can slow down or improve thinking and memory decline over 76 weeks. Participants are randomly assigned to r…

This study tests whether metformin, a common diabetes medicine, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). Researchers will give metformin or a placebo to 54 people aged 60-75 for 26 weeks. They will use brain scans a…

This study is testing whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 people aged 55 to 89 will take rapamycin for 12 months. Researchers will monitor side effects and check if the drug reaches the…

This study explores whether a simple smell test can help detect early signs of Alzheimer's and other brain diseases. Researchers will have 250 adults with mild memory or behavior concerns, plus healthy older adults, take a 45-minute at-home smell test. The goal is to develop a lo…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults, including healthy volunteers and those with memory problems, using a high-sensitivity scanner…

This study is testing whether a new blood test can accurately diagnose the cause of memory problems, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If successful, it…

This study looks at whether specific brain-training exercises can help older adults with mild memory problems delay or prevent dementia. About 1,300 people aged 55–89 with mild cognitive impairment will try different combinations of cognitive training or general mental stimulatio…

This study tests whether a 6-month online educational program called Brain Health PRO can help people at risk for dementia make lasting lifestyle changes—like improving diet, exercise, sleep, and social connections. About 700 Canadian adults with mild memory concerns or risk fact…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during a hospital stay. One program uses hospital staff, while the other also involves family members or care partners. The goal is to see which approach works better to reduce confus…

This study tests a pressure-sensor mat and linked software program designed to improve thinking and balance in older adults. About 205 community-dwelling seniors aged 65+ will participate in group training sessions led by a fitness coach. The mat tracks foot placement on a screen…

This study tests a system called Sense4Safety that uses home sensors and a coach to help older adults with mild cognitive impairment reduce their risk of falling. About 200 people aged 65 and older who live in senior communities will take part. The system monitors movement, spots…

This study tests a smart virtual reminiscence therapy (SVR) designed to reduce behavioral and psychological symptoms like agitation, anxiety, and depression in older adults with mild cognitive impairment or early dementia. About 60 participants will use the AI-powered talk therap…

This study tests whether personalized, virtual music therapy sessions can boost memory and mood in people with mild Alzheimer's disease or mild cognitive impairment. Sixty participants will receive two 30-minute music sessions per week for 8 weeks. Researchers will measure change…

This study tests whether combining an NMDA-enhancing drug with an antioxidant can improve thinking and memory better than the NMDA drug alone. Researchers will enroll 80 people with early Alzheimer's or mild cognitive impairment. Participants will take the combination for 24 week…

This study tests a 3-month exercise program for people with mild cognitive impairment (early memory loss) due to Alzheimer's. Participants will do exercises that combine physical and mental tasks twice a week. Researchers want to see if this improves walking, balance, and thinkin…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, have MRI brain scans, and complete memory and physical te…

This study explores whether group drumming can help reduce pain and improve well-being in people with early Alzheimer's or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will take part in community drum circles while researchers measure pain…

This study tests whether doing special visual exercises on a computer can improve attention and thinking speed in older adults with mild cognitive impairment (MCI). About 40 people aged 60 and older will either do these exercises or watch TV for 30 days. Researchers will compare …

This study explores whether rhythmic light therapy can improve memory and brain function in people with mild cognitive impairment. Twenty participants will attend three sessions with different light patterns while their brain activity is recorded. The goal is to see if certain li…

This early-phase study is testing whether psilocybin, a hallucinogenic drug, can safely help with depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive the drug in a supportive setting. The main goal is to see if depres…

This study tests whether a simple smell training program can improve memory, thinking, and daily function in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Thirty participants aged 55-89 will be randomly assigned to either smell training…

This study looks at whether a safe, non-invasive brain stimulation technique called TMS can help older adults (ages 60-85) who have mild memory problems and depression. Researchers want to find the best dose of TMS to improve both mood and thinking. The goal is to gather informat…

This study looks at whether a special type of brain stimulation, combined with aerobic exercise, can improve thinking and walking ability in older adults who are both frail and have mild memory problems. About 45 people aged 60-90 will take part. The goal is to find a better way …

This study looks at whether over-the-counter hearing aids can improve communication for people over 60 with mild hearing loss and mild cognitive impairment or early Alzheimer's. Participants and their communication partners will try either hearing aids first or special communicat…

This study tests whether a non-invasive device that uses focused ultrasound waves on the brain can safely improve movement problems in people with Parkinson's disease. About 60 adults with Parkinson's will receive either real or sham (fake) ultrasound sessions. Researchers will m…

This early-stage study tests whether breathing slightly low-oxygen air in short sessions (intermittent hypoxia training) is safe and can improve memory and thinking in adults aged 55–79 with mild cognitive impairment. Participants are randomly assigned to receive the real treatme…

This study tests whether a 6-week home-based virtual reality program, guided remotely by a therapist, can improve memory, attention, and social skills in adults aged 40-80 with early memory concerns. Participants will be randomly assigned to either the VR program or traditional p…

This study tests whether a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) can safely increase brain activity in a memory-related area and possibly improve memory. About 144 adults aged 50–90 with mild cognitive impairment or mild Alzheimer's will…

This study tests whether playing online games with others can reduce loneliness and improve social connections in older adults, including those with mild cognitive impairment (MCI). Researchers will measure changes in feelings of isolation, loneliness, and quality of life. The go…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can improve cognitive control in healthy adults and older adults with mild cognitive impairment (MCI). Participants play a cognitive video game while a brain-computer interfac…

This small pilot study tests whether a non-invasive brain stimulation technique called rTMS can reduce apathy in people with dementia or mild cognitive impairment. Apathy—lack of interest or motivation—is common and disabling. The study includes 10 participants, some already taki…

This study looks at whether low-intensity exercise that combines physical and mental activities can help improve memory and thinking in older adults with mild cognitive impairment (MCI). Researchers will compare a group that does this exercise three times a week for three months …

This study looks at whether a simple home-based walking program can help improve memory, thinking speed, and brain structure in older adults who have both chronic kidney disease and mild cognitive impairment. About 144 participants aged 55 and older will walk regularly for 6 mont…

This study tests a safe, non-invasive brain stimulation technique called RS-tDCS+ that is used at home alongside computer-based cognitive training. The goal is to improve attention and concentration in active-duty service members and veterans who have had a mild traumatic brain i…

This study tests whether playing soft sounds during deep sleep can make cognitive training more effective for people with Parkinson's disease and mild memory problems. Fifty participants will do a 5-week brain fitness program at home while using a sleep device that either plays r…

This study looks at whether a dental mouthpiece works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older with moderate-to-severe sleep apnea will be randomly assigned to use ei…

This study tests a small device worn on the ear that sends gentle pulses to a nerve, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four adults aged 55 to 89 will use the device at home for 30 minutes daily over four we…

This study is testing a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, …

This study looks at whether eating only during a 10-hour daytime window (and fasting for 14 hours at night) can improve sleep, thinking, and brain health in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Researchers will compare two fasting schedu…

This study tests a computerized anxiety sensitivity treatment (CAST) in 388 older adults with mild cognitive impairment or mild Alzheimer's disease and their care partners. Participants attend two treatment sessions and are followed for six months. The goal is to see if CAST redu…

This study tests a program called the Green Activity Program, designed for people with mild memory issues or early Alzheimer's. The program encourages enjoyable outdoor activities like walking, gardening, or yoga with a friend or pet. Researchers want to see if the program is eas…

This study tests whether high-intensity interval training (HIIT) or moderate-intensity continuous exercise better improves thinking skills and physical fitness in older adults with mild cognitive impairment (MCI). Sixty-eight participants will exercise three times a week for eigh…

This study tests whether a gentle, non-invasive brain stimulation technique called tDCS can improve thinking and memory in people with Parkinson's disease who have mild cognitive problems. About 36 participants will receive either real or fake stimulation to see if it helps resto…

This study explores whether a non-invasive technique called repetitive transcranial magnetic stimulation (rTMS) can improve memory in healthy young and older adults, as well as in people with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's d…

This study tests whether a 12-week home-based strength training program, guided by video calls, is practical for adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Researchers will track how many people finish the program and how often they exercise. The goal i…

This study tests whether a special type of tai ji quan that combines physical movement with mental tasks can reduce falls in older adults with mild cognitive impairment (MCI). Researchers will enroll 336 people aged 65 and older who have memory complaints and a history of falls o…

This study tests a non-invasive brain stimulation method called deep TMS in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. The treatment uses a special coil to stimulate deeper brain areas fo…

This study tests whether a supplement called MitoQ can improve blood vessel health, physical mobility, and thinking skills in frail older adults aged 65 to 80. Participants take MitoQ or a placebo for a period, and researchers measure changes in walking speed, memory, and blood f…

This study looks at whether exercising before a gentle brain stimulation technique (tDCS) can improve memory in people aged 50+ with mild cognitive problems and heart or blood vessel risk factors. Participants will exercise and then receive brain stimulation, and their memory and…

This study tests a medical device called Neuclare that is placed on the head to see if it can temporarily improve thinking and planning skills in people with mild cognitive impairment or very early Alzheimer's disease. About 138 adults aged 55 to 90 who are already on memory medi…

This study is for adults who have had a stroke (blood clot or bleeding in the brain). Researchers want to learn why some people develop memory and thinking problems after a stroke, while others do not. They will use brain scans, blood tests, and memory tests to find clues. The go…

This study explores whether playing a navigation-based digital game can improve long-term memory in healthy older adults and those with mild cognitive impairment. Participants will play the game at home for up to 8 weeks and complete memory tests before, after, and 6 months later…

This study looks at why some people improve their thinking skills after a brain injury while others don't. Researchers will have 30 adults with mild cognitive problems do intensive computer-based brain exercises. They will measure changes in thinking, brain activity, and blood ma…

This study tests whether a supplement called nicotinamide riboside can affect brain energy and stress in people with mild memory problems or early Alzheimer's. Researchers will use home sensors to track sleep, movement, and walking speed over 12 weeks. The goal is to find new way…

This study looks at whether proteins in the blood can help predict if someone will develop Alzheimer's disease or memory problems. Researchers will test blood samples from 1,800 older adults and compare them with brain scans and thinking tests. The goal is to develop a simple blo…

This study aims to create a model that better predicts how different types of dementia will progress over time. Researchers will follow 500 people with early dementia or mild cognitive impairment, using blood tests and thinking assessments. The goal is to improve prognostic confi…

This study uses a safe, noninvasive light-based technique called fNIRS to measure brain activity in 200 adults with depression, bipolar disorder, or mild cognitive impairment. Researchers will compare brain patterns across groups and link them to symptom severity. The goal is to …

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to changes in the brain that cause memory problems in older adults. Researchers will use a gentle brain stimulation technique and blood tests to understand these connections. The st…

This study looks at whether hearing tests can detect early signs of memory and thinking problems in people with Mild Cognitive Impairment (MCI). Researchers will compare hearing and thinking abilities between 70 adults with MCI and healthy volunteers aged 55-80. The goal is to se…

This study aims to create a large, diverse group of 1,000 older adults (age 60+) to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will have yearly check-ups including memory tests, brain s…

This study looks at how mild cognitive impairment (MCI) affects the brain's ability to make quick decisions and move at the same time. Researchers will track hand movements and brain structure in 60 adults aged 45-90, including those with MCI and healthy volunteers. The goal is t…

This study is gathering data from 1,200 older adults (ages 60-90) who are either cognitively normal, have mild memory problems, or have mild-to-moderate Alzheimer's. Researchers will collect blood samples, digital measurements (like from apps or devices), and brain scans to see i…

This study explores whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Participants will receive daily brain stimulation sessions ov…

This study explores whether pharmacies can serve as community hubs to identify older adults with early memory issues or mild dementia. Over 1,000 participants aged 60+ will take a digital memory test at a pharmacy, and those with concerning results will be guided to doctors or su…

This study looks at how a gentle, non-invasive brain stimulation technique affects brain activity and memory in healthy older adults and those with mild memory problems. Researchers will use brain scans and memory tests to measure changes. The goal is to better understand how the…

This study uses special PET scans to measure inflammation in the brains of people with diseases like Alzheimer's, Parkinson's, and ALS, compared to healthy volunteers. Researchers want to see if certain proteins called COX-1 and COX-2 are higher in diseased brains. About 184 adul…

This study uses special eye scans to look for early signs of brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers will examine the tiny blood vessels and layers in the eyes of 2,000 adults—both healthy and with brain conditions—to see if eye changes c…

This study tests whether combining computer-based brain training with aerobic exercise can improve brain function in people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Researchers will measure changes in brain structure, blood flow, and thin…

This study looks at whether a tablet-based test called TabCAT can help primary care doctors find early signs of memory loss or dementia in older adults. The test is quick, scores itself, and links to the patient's medical record. Researchers will compare detection rates in 26 Kai…

This study tests whether a non-invasive brain stimulation technique called TMS can improve working memory in healthy older adults and those with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation for each participant. The goal is to u…

This study tests a new imaging tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers aged 50 and older, including healthy individuals. The goal is to better understand …

This study looks at whether improving deep sleep can help protect against Alzheimer's disease in older adults. Researchers will ask 116 people aged 65-85 with mild sleep issues to slightly reduce time in bed for four weeks to boost deep sleep. They will measure changes in memory,…

This study is looking for early warning signs of Alzheimer's disease in 800 healthy adults aged 50 to 80. Researchers will use brain scans, spinal fluid, and blood tests to track changes over about 4 years. The goal is to find better ways to screen for Alzheimer's before memory p…

This study uses special eye cameras to look for blood vessel changes and protein deposits in the retina of people with Alzheimer's or mild dementia. Researchers will compare these eye scans to those of healthy older adults. The goal is to find a simple, noninvasive way to spot ea…

This study looks at whether a Memory Support System (MSS) is practical for people with mild cognitive impairment (MCI) and their care partners at a clinic in Ontario, Canada. Researchers will ask 40 participants about their interest in the program, track how well they follow it, …

This study looks at whether a simple eating schedule—eating all meals within a 10-hour window each day—is practical for women with mild cognitive impairment (early memory loss). The goal is to see if women can stick to this routine, which might help delay Alzheimer's disease. The…

This study aims to identify early risk factors for Alzheimer's disease by following 850 adults with normal memory or mild cognitive issues. Researchers will track changes in thinking skills, brain scans, and spinal fluid markers over time, with a special focus on how blood sugar …

This study tests a web-based platform called LEAD that helps people in the early stages of Alzheimer's or mild cognitive impairment talk about and write down their end-of-life wishes. About 120 participants and their care partners will use the tool to see if it improves decision-…

This study tests whether playing an immersive virtual reality game can improve memory in 200 older adults with mild memory decline. Participants will undergo memory tests and brain scans to see if the training strengthens brain connections. The goal is to find a non-drug way to h…

This study follows nearly 3,000 people, including healthy volunteers and those with memory or movement problems, to track how brain diseases like Alzheimer's and Parkinson's develop over time. Researchers use advanced brain scans and tests to find early signs of disease. The goal…

This study is testing whether simple blood tests and brain scans can help doctors in primary care detect Alzheimer's disease and other memory disorders earlier and more accurately. Researchers will recruit 1,200 adults with mild memory or thinking complaints. The goal is to impro…

This study looks at whether the same amyloid deposits found in the brains of people with Alzheimer's disease can also build up in the heart and cause heart problems. Researchers will use special PET scans to check the hearts of 15 Alzheimer's patients who are already getting brai…

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis over time. The goal is to gather data, not to test a treatment, so there is no …

This study looks at how people with mild cognitive impairment (MCI) or Alzheimer's disease adjust their walking to changes in their environment. Researchers will test 10 older adults using special treadmills and walking tasks to measure how well they adapt their steps. The goal i…

This study explores whether a simple, non-invasive eye-tracking test using virtual reality can detect early cognitive decline in people with Alzheimer's disease, mild cognitive impairment, or depression-related memory problems. Researchers will measure how pupils react during mem…

This study explores whether artificial intelligence can estimate a person's cognitive test scores by analyzing a short speech recording. 150 adults aged 50 and older will tell a story based on a picture while their voice is recorded. The AI's predictions will be compared to stand…

This study looks at whether mild traumatic brain injuries (mTBIs) in Veterans increase the risk of dementia. Researchers will measure memory, brain waves, brain structure, and certain proteins in 800 participants. The goal is to find early signs of brain changes related to Alzhei…

This study looks at how stress hormones and certain genes might speed up memory loss in older adults with mild cognitive impairment. Researchers will test memory and collect blood and saliva samples after a short stressful task. Participants return after two years to see if stres…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild memory problems. Researchers want to see how tau relates to thinking skills, brain activity, and the risk of future decline. About 105 people aged 55–90 who …