Mild cognitive impairment

This trial tests whether a compound called 2-HOBA can safely reduce harmful protein modifications in the brain that are linked to Alzheimer's disease. About 48 people with mild cognitive impairment or mild Alzheimer's will take either 2-HOBA or a placebo daily for 12 weeks. Resea…

This study investigates whether a special cooking oil called diacylglycerol (DAG) oil can improve thinking skills and reduce body weight in adults aged 45 to 75 who have both obesity and mild cognitive impairment. Participants replace their usual cooking oil with either regular r…

This study tests whether a daily 240 mg dose of Ginkgo biloba extract can change certain blood markers linked to Alzheimer's disease in people with mild cognitive impairment. Over 6 months, 120 participants will be randomly assigned to receive either Ginkgo biloba or a placebo. T…

This study tests whether a mild electrical stimulation applied to the ear (via a small device) can improve memory and thinking in people with type 2 diabetes who also have mild cognitive impairment. The trial will involve 38 participants who will either receive the active stimula…

Researchers at Emory University are studying a modified Argentine tango program called Adaptango for adults with Parkinson's disease, mild cognitive impairment, or dementia, alongside younger adults. Over three months, participants take part in biweekly choreographic sessions tha…

Researchers are testing whether short bouts of Baduanjin, a traditional Chinese mind-body exercise, can improve thinking and memory in older adults with mild cognitive impairment. The trial enrolls 240 people aged 51 to 80 across multiple centers in China. Half receive routine he…

This pilot trial compares an adapted form of mindfulness-based cognitive therapy with a health education program in older Black adults who have chronic pain and early cognitive decline. The goal is to see if the mindfulness approach can improve quality of life and reduce how much…

This trial tests a mobile app called the Social Reminder System, designed to help people with memory concerns stay socially engaged. The app sends reminders on a home tablet when a trusted friend or family member is nearby, potentially encouraging more visits and interactions. Re…

This study tests whether a structured cognitive training program can improve memory, attention, and other thinking skills in older adults who have type 2 diabetes and mild cognitive impairment. Participants will be randomly assigned to either the cognitive intervention or a contr…

This study tests a sleep therapy called SleepSMART for older veterans who have both insomnia and mild cognitive impairment (MCI). The therapy adapts standard insomnia treatment with extra memory and learning support. Researchers will compare SleepSMART to standard therapy in 150 …

This study tests a mobile app called LifeBio Memory that helps older adults with mild cognitive impairment share their life stories using photos, voice recordings, and culturally tailored prompts. The app aims to improve quality of life, reduce depressive symptoms and loneliness,…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests whether combining a gentle brain stimulation technique (rTMS) with walking and eye exercises can improve balance and reduce fall risk in 30 adults aged 18-80 with or without mild cognitive impairment. Participants will practice stepping onto targets while their e…

This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

This study tests whether a digital exercise program using video games (exergames) can improve quality of life and physical function in older adults with mild cognitive impairment living in care homes. Thirty-eight participants will either play exergames or do standard physiothera…

This early-phase study tests whether brivaracetam, a seizure medication, can calm overactive brain areas and improve thinking in 25 adults aged 45–70 with mild Alzheimer's or mild cognitive impairment. Participants will have brain activity monitored via scalp and depth electrodes…

Researchers are studying whether navigational memory fades before other spatial memory in people with Parkinson's disease and related conditions. The pilot includes 80 participants: those with mild or advanced Parkinson's, those with parkinsonism, and healthy volunteers. Particip…

This study looks at whether a virtual reality (VR) program called CAST can help older adults with mild cognitive impairment (mild memory problems) stay socially and mentally engaged. Researchers will test how easy and enjoyable the VR system is for 312 people aged 65 and older. T…

This study is developing and testing an intelligent software system designed to provide cognitive and social support to older adults with mild cognitive impairment (MCI). The software adapts to each user's abilities and needs. Researchers will enroll 290 participants aged 62 and …

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study will follow 1,000 older adults from under-resourced communities who have early memory concerns or mild cognitive impairment. Participants will be monitored through phone or video visits, with data collected on thinking skills, brain scans, and blood samples. The goal i…

This study will test if wearable devices like smartwatches and rings can detect early signs of mild cognitive impairment and Alzheimer's disease in 150 adults aged 65 and older. Participants will wear the devices for 30 days while researchers collect data on activity, sleep, and …

This study tests whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, can improve the brain's natural waste-clearing system (glymphatic function) in people with mild cognitive impairment. Researchers will give TMS to 20 participants to see …