MILD COGNITIVE IMPAIRMENT

This study tested whether a dietary supplement called citicoline could improve sleep and affect biological markers related to Alzheimer's disease in older adults with mild memory problems. One hundred participants were randomly assigned to receive either the supplement or a place…

This study tested a special device that sprays insulin into the nose, aiming to deliver it directly to the brain. Researchers wanted to see if this method could increase insulin levels in the fluid around the brain and potentially improve memory in people with mild cognitive impa…

This study tested whether a daily drink made from perch fish could help improve memory and thinking skills in people with mild cognitive impairment (MCI). For 24 weeks, 54 participants either drank the perch essence or a look-alike fish broth. Researchers measured changes in cogn…

This study tested whether gentle electronic reminders could help doctors and caregivers safely reduce unnecessary medications for people with dementia. Researchers sent automated messages to 250 primary care doctors and their dementia patients' caregivers before appointments, sug…

This Phase 2 study tested whether XPro1595 could help people with early Alzheimer's disease who show signs of brain inflammation. The trial involved 208 participants aged 50-85 who received either the drug or a placebo for 24 weeks. Researchers measured changes in memory, thinkin…

This study tested if a 12-week time-restricted eating plan was practical and acceptable for older adults with mild memory problems and obesity. Participants worked with a psychologist to fast for 16 hours on 2-3 days each week. Researchers measured changes in memory, thinking ski…

This study tested whether computer-based brain training exercises could improve thinking skills and reduce depression in older adults who were already taking antidepressants. Researchers enrolled 38 older adults with mild to major depression, some with mild memory concerns, and r…

This study tested whether a non-invasive brain stimulation technique could improve thinking skills in veterans with mild cognitive impairment or early dementia. Researchers used magnetic pulses on the forehead to stimulate brain areas involved in memory and decision-making. They …

This study tested whether a nasal insulin spray and a diabetes pill (empagliflozin), alone or together, could help people with early memory loss or Alzheimer's disease. It involved 47 adults aged 55-85 who showed early signs of Alzheimer's. The main goal was to check if the treat…

This study tested if a personalized, detailed treatment plan works better than standard care for people with early memory loss or mild dementia. For 9 months, one group followed a plan tailored to their specific test results, focusing on diet, exercise, and other lifestyle factor…

This study tested whether lithium, a medication long used for mood disorders, could help slow or prevent Alzheimer's dementia in older adults with mild memory problems. 83 participants with mild cognitive impairment were randomly assigned to take either lithium or a placebo pill …

This study tested whether an old, common blood pressure drug called spironolactone is safe and tolerable for older African American adults who have early memory and thinking problems. The goal was to see if the drug could help slow the decline in memory skills. A small group of 2…

This study tested whether wearing a nicotine skin patch daily for two years could improve memory, thinking, and daily function in older adults with mild cognitive impairment. Researchers enrolled 348 participants aged 55-90 who were experiencing early memory problems but not full…

This study tested a program to help reduce unnecessary or risky medications for people with dementia. A pharmacist met with patients and their caregivers via video call to review all medications based on the patient's personal health goals. The goal was to see if this approach sa…

This small pilot study tested whether combining physical exercise with a mild, non-invasive brain stimulation technique could help improve memory in people with mild cognitive impairment or early Alzheimer's disease. Researchers wanted to see if stimulating the brain during exerc…

This study tested whether a gentle, non-invasive form of brain stimulation could help people with early Alzheimer's disease. Researchers used a device to deliver a specific electrical frequency to the brain, hoping it would reduce the buildup of harmful proteins linked to memory …

This study tested whether a special daily light treatment at home could help people with early memory loss or mild Alzheimer's disease. Researchers wanted to see if the light could improve sleep, reduce body inflammation, help the body process sugar better, and slow cognitive dec…

This study tested whether a computer program called SUPERBRAIN DEX could help people with mild cognitive impairment (MCI), an early stage of memory and thinking problems. Researchers compared the software against a control group in 140 older adults to see if it safely improved co…

This study tested whether a high dose of the antiviral drug valacyclovir, commonly used for herpes, could slow down early memory loss linked to Alzheimer's disease. It involved 50 older adults who had mild memory problems, tested positive for herpes simplex virus, and showed earl…

This study tested whether a 12-week program of brain training, physical exercise, and healthy lifestyle coaching could help improve or maintain thinking skills in older adults. 120 participants, aged 50-75 with normal memory or mild memory concerns, were randomly assigned to eith…

This study tested whether different types of exercise could help control cognitive decline in older adults with mild memory problems. Researchers compared aerobic exercise, strength training, a combination of both, and basic balance exercises over six months. They measured change…

This study tested a combination of three non-drug therapies to see if they could help improve memory, thinking, and quality of life in older adults with mild cognitive impairment or Alzheimer's disease. Thirty-three participants received either the active treatment or a sham (pla…

This study tested whether an AI platform can detect early signs of mild cognitive impairment and dementia by analyzing people's speech. Researchers compared the AI's analysis of speech patterns with results from standard paper-and-pencil memory tests. The goal was to see if speec…

This study tested whether specific proteins in the blood can accurately diagnose Alzheimer's disease. Researchers compared blood test results from 342 patients with results from the current standard spinal fluid test and clinical assessments. The goal was to see if a less invasiv…

This study tested whether a simple, non-invasive brain wave recording (EEG) could help identify Alzheimer's disease at various stages. Researchers collected EEG data from 29 people, including those with no symptoms but at genetic risk, mild memory problems, and different stages o…

This study tested whether a special type of MRI scan (which doesn't use radiation) could work as well as a standard PET scan (which does) for spotting early brain changes in people with mild memory problems. Researchers compared the two scans in 150 people with mild cognitive imp…

This study tested whether a 24-week program of home-based physical activity and computer brain training could help prevent or delay memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older to compare different combinations of the exercise an…

This study tested whether daily supplements made from chicken extract or peptides could help prevent cognitive decline in older adults. 276 participants aged 55-75 who were concerned about their memory but didn't have dementia took either the supplements or a placebo for two year…

This study tested whether taking a special turmeric supplement for six months could help protect brain function in older adults with metabolic syndrome, a condition that increases the risk of memory problems and Alzheimer's disease. Researchers gave 85 participants either the tur…

This small pilot study tested an online educational program designed to teach people about dementia and lifestyle changes that may help prevent it. The study involved 20 adults who were at increased risk for dementia but did not have it yet. Researchers wanted to see if the onlin…

This study tested whether a simple home exercise program could help prevent future falls in older adults who have memory concerns and recently broke a hip from a fall. Researchers compared the exercise program to usual care in 60 participants over six months. The goal was to see …

This study tested whether a 6-week online sleep therapy program (Sleepio) is practical and acceptable for people with mild memory problems or early-stage dementia who also have trouble sleeping. Thirty adults aged 50+ tried the program or were placed on a waitlist to see if it co…

This study tested whether a safe, non-invasive brain stimulation technique, combined with mental exercises, could improve concentration and memory in active-duty military members who had a past mild traumatic brain injury. Fifty-six participants received either real or fake (sham…

This small, early-stage study tested a new computer program designed to help people with mild cognitive impairment (MCI), which involves early memory and thinking problems. The program combined mind-body exercises like gentle movement and acupressure. Researchers mainly wanted to…

This study tested a new smart home system designed to help Spanish-speaking caregivers of people with dementia or memory problems. The system uses sensors and internet-connected devices to monitor the person being cared for and provide support to the caregiver. Researchers wanted…

This small pilot study tested whether a personalized program combining different types of therapy and lifestyle advice is practical and helpful for people with conditions affecting thinking and memory, like brain injuries or multiple sclerosis. Fifteen participants were randomly …

This study investigated whether learning to play the traditional board games Go or Chess could help people with early memory concerns. 80 participants with mild cognitive impairment or subjective cognitive decline were assigned to learn one game, both games, or be in a control gr…

This study tested whether gentle electrical stimulation applied to the skin could help improve memory in older adults with mild cognitive impairment. Participants were randomly assigned to receive either real stimulation or one of three control procedures while completing memory …

This study tested an oral medication called SAGE-718 to see if it could improve cognitive performance, specifically processing speed, in people with mild memory problems or early dementia due to Alzheimer's disease. It involved 174 participants who were randomly assigned to recei…

This study tested whether a noninvasive brain stimulation technique could improve memory in older adults with mild cognitive impairment. Participants received either active magnetic stimulation to specific brain areas or a placebo treatment over several weeks. Researchers measure…

This study tested whether a non-drug coaching method called Strategy Training could help older adults with mild cognitive impairment maintain their ability to perform daily tasks like shopping, managing medications, and paying bills. Researchers compared Strategy Training against…

This study tested a new in-home technology system designed to help family members caring for loved ones with dementia or memory loss. The system uses sensors, smart devices, and apps to monitor safety and provide support, aiming to reduce the caregiver's stress, anxiety, and feel…

This study tested whether a special brain training technique could help improve memory in older veterans. Researchers used a wearable headset that gives real-time feedback about brainwaves during memory tasks. The goal was to see if veterans could learn to adjust their brain acti…

This small pilot study tested whether a combination of gentle, non-invasive brain stimulation and computer-based memory training was a practical approach for people with mild cognitive impairment (MCI). Eight participants aged 50-90 with early memory loss completed the study. The…

This study tested whether having a special conversation about personal care priorities could help people with mild memory loss or dementia. 178 patients received information before a clinic visit and could talk with a trained helper about what matters most to them. Researchers th…

This study tested whether magnetic stimulation applied to the front of the brain could improve apathy—a severe loss of motivation—in older Veterans with mild memory problems. Participants received either real or fake stimulation over 20 sessions to see if it could restore motivat…

This study tested a 6-week virtual program designed to help couples where one partner has mild cognitive impairment (MCI). The program taught communication skills and coping strategies to help both partners feel more in control and less stressed. Researchers measured whether coup…

This small, completed study tested whether a non-invasive brain stimulation technique could improve memory in people with mild cognitive impairment (MCI). Researchers wanted to see if it was practical to run this type of trial and to gather early data on whether stimulating diffe…

This study tested whether participating in arts activities like theater, dance, music, or museum visits could improve mental health. Over 500 adults in Greece with conditions like depression, anxiety, or schizophrenia were randomly assigned to either join weekly arts sessions for…

This study tested whether an existing injectable medication called tesamorelin could improve memory and thinking skills in older adults living with HIV who were experiencing mild cognitive problems. Researchers enrolled 73 participants who also had excess abdominal fat, as this i…

This study tested whether a single drink containing a special milk protein (alpha-lactalbumin) could improve mood and thinking skills in healthy older adults, including some with mild memory concerns. Researchers compared the effects of this protein to other proteins by measuring…

This study tested whether a friendly robot could help people with dementia or memory problems feel more socially connected and engaged. For three weeks, residents, their families, and staff in an assisted living community tried using a robot that led activities like trivia and ga…

This study tested whether an 8-week program of social video calls could improve quality of life for older adults, including those with mild memory concerns. About 100 participants aged 65+ were randomly assigned to either start the video social groups immediately or wait 8 weeks.…

This study tested whether regular music therapy sessions focused on singing could help improve memory, language, and quality of life for people with Alzheimer's disease or mild cognitive impairment. Over 100 participants were assigned to different schedules of music therapy for a…

This study tested a new sleep therapy program designed for older veterans who have both memory problems and trouble sleeping. The program combines standard sleep therapy with special memory support strategies to help participants follow the treatment better. Researchers wanted to…

This study tested whether three different online wellness programs could help improve thinking skills and brain connections in older adults experiencing memory problems. Seventy-seven participants aged 55 and older were randomly assigned to take part in either online Tai Chi, a m…

This study tested whether a gentle electrical stimulation applied to the scalp could help improve memory and thinking in people with mild cognitive impairment or early Alzheimer's disease. Researchers gave different amounts of stimulation to 269 participants while using brain sca…

This study tested whether a special, tailored lighting treatment could help people with Alzheimer's or dementia sleep better and improve their mood and thinking. Researchers compared the active light treatment to a placebo light for six months in 101 participants. They measured c…

This study tested a new way to help older adults with mild memory problems get more benefit from computer brain training. Researchers wanted to see if first making computers more enjoyable and personal for participants would help them engage better with the training that followed…

This completed study aimed to understand if specific proteins in the blood (IGF-I and IGFBP-3) are linked to Alzheimer's disease and memory problems. Researchers compared levels of these proteins in three groups: people with Alzheimer's, people with mild memory issues, and health…

This small, completed study tested three different nasal spray devices to see how well they could deliver insulin into the brain's fluid. Researchers also checked if the insulin had any short-term effects on memory. The main goal was to gather information to help design better fu…

This study looked at whether daily text message reminders help people with early Alzheimer's or mild memory problems stick to a morning light routine. Researchers enrolled 20 adults over 55 to test if the reminders improved their compliance. They used light sensors and sleep trac…

This study aimed to discover new signs in blood and urine that could help detect Alzheimer's disease earlier. Researchers analyzed samples from 95 people, including those with normal memory, mild thinking problems, and different stages of Alzheimer's. The goal was to find pattern…

This study aimed to find out if measuring certain proteins in the blood could help predict Alzheimer's disease. Researchers followed over 1,000 people with either mild memory problems or early Alzheimer's to see if their blood test results could forecast who would get worse or ho…

This study aimed to understand if and how a common heart valve replacement procedure (TAVR) affects memory and thinking skills in patients who already have mild cognitive impairment. Researchers followed 81 patients, testing their memory before the procedure, then 30 days and 6 m…

This study aims to understand if the community of bacteria in the gut is different in people with early Alzheimer's disease or mild cognitive impairment compared to healthy adults. Researchers will observe 44 participants, including those with memory issues and healthy volunteers…

This study explored how people with mild memory problems or early Alzheimer's disease understand and emotionally handle learning the results of their brain scans. Researchers educated 152 participants about brain proteins linked to Alzheimer's, then shared their personal scan res…

This small pilot study tested whether a smartphone app could measure thinking and memory skills in older adults before major spine surgery. The goal was to see if these remote tests could help identify patients who might be at higher risk for developing confusion (delirium) after…

This study looked at whether a special brain scan (amyloid PET) helps doctors make better care decisions for people with memory problems or dementia. It followed over 6,000 Medicare patients from diverse backgrounds to see if the scan results changed their treatment plans and hea…

This study tested a Spanish version of a balance assessment tool designed for frail seniors living in nursing homes who have mild memory problems. Researchers wanted to see if this specific test is a reliable and valid way to measure balance issues in this vulnerable group. The g…

This early-stage study tested whether baricitinib, a drug approved for rheumatoid arthritis, can get into the spinal fluid and reduce signs of brain inflammation in people with Alzheimer's disease, ALS, or early memory concerns. Seventeen participants took the pill daily for 24 w…

This study explored whether taking music improvisation classes could help improve self-regulation and thinking skills in older adults. Researchers enrolled 53 adults aged 60 and over, some with mild memory concerns and some without, to test the new training program. The goal was …