MILD COGNITIVE IMPAIRMENT

This study tested whether a common antiviral drug, valacyclovir, could slow memory decline in 50 older adults with mild cognitive impairment (early memory loss) who also carry the herpes simplex virus. Participants took either the drug or a placebo for 52 weeks. The goal was to s…

This study tested the drug baricitinib, currently used for arthritis, in 17 people with Alzheimer's disease, ALS, or early memory problems. The goal was to see if the drug could reach the brain and reduce inflammation linked to these diseases. Participants took the drug for 24 we…

This study tested an experimental drug called XPro1595 in 208 people with early Alzheimer's who also had signs of brain inflammation. The goal was to see if the drug could improve thinking, memory, and daily function compared to a placebo. Researchers also checked for safety and …

This study tested a physical activity program called Tiempo Juntos para la Salud (Time Together for Health) in 234 Spanish-speaking Latinos aged 55 and older with mild cognitive impairment. The program encouraged moderate exercise to improve thinking, heart health, and sleep. Par…

This study tested whether a personalized treatment plan, based on each person's test results, works better than standard care for people with mild memory problems or early dementia. 73 adults aged 45-76 took part. The approach involved blood, urine, and stool tests, lifestyle cha…

This study tested whether a nasal insulin spray combined with the diabetes drug empagliflozin can safely improve memory and thinking in people with early Alzheimer's or mild cognitive impairment. 47 adults aged 55-85 with signs of Alzheimer's in their brain took part. The goal wa…

This study tested a vaccine called ABvac40 in 134 people with very mild Alzheimer's or mild cognitive impairment. The vaccine aims to train the immune system to attack a specific protein (Aβ40) linked to Alzheimer's. The main goal was to check safety and immune response over 24 m…

This study tested whether an AI tool called AcceXible can detect early signs of dementia or mild cognitive impairment by analyzing how people describe images. Researchers recorded speech from 273 adults aged 55 and older, including healthy volunteers and those with memory concern…

This study tested whether an artificial intelligence system could detect mild cognitive impairment and Alzheimer's disease by analyzing people's self-figure drawings. Over 3,400 older adults participated, drawing themselves on paper. The goal was to create a simple, non-invasive …

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict if someone with mild memory problems will develop Alzheimer's. Over 1,000 older adults with either mild cognitive impairment or Alzheimer's dis…

This study looked at whether a blood test can accurately diagnose Alzheimer's disease, instead of the usual spinal fluid test. Researchers tested 342 adults visiting memory clinics. They measured certain proteins in the blood and compared results to standard diagnostic methods. T…

This study tested whether a non-invasive, painless technique called repetitive transcranial magnetic stimulation (rTMS) can help prevent memory decline in people with mild cognitive impairment (MCI) or those at high genetic risk for Alzheimer's disease. Researchers used brain sca…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. Researchers enrolled 253 women aged 65 and older with a history of cardiovascular disease who were not alrea…

This study looked at whether lithium, a medication already used for mood disorders, could delay or prevent Alzheimer's disease in older adults with mild cognitive impairment (MCI). Researchers measured memory, thinking skills, and brain changes in 83 participants over time. The g…

This study tested whether a chicken extract and a peptide supplement could help prevent memory and thinking decline in older adults without dementia. 276 people aged 55-75 with either mild memory concerns or mild cognitive impairment took the supplements or a placebo for two year…

This study tested a non-invasive brain stimulation method called tACS in 17 people with early to moderate Alzheimer's. The goal was to see if daily sessions over 2-4 weeks could safely reduce amyloid and tau buildup in the brain and improve memory and thinking. Participants recei…

This small pilot study tested whether combining a gentle, non-invasive brain stimulation technique (high-definition transcranial direct current stimulation) with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants comp…

This study looked at whether different types of exercise can improve thinking and memory in older adults with mild cognitive impairment, a condition that can lead to dementia. Researchers compared aerobic training (like walking), resistance training (like lifting weights), and a …

This study tested whether taking part in arts activities (like painting, music, or theater) can improve mental health and well-being in adults with psychiatric diagnoses. Over 500 participants were randomly assigned to either an art program or a waitlist. The main goal was to see…

This study tested a computer-based program that combines mental exercises and relaxation techniques for people with mild cognitive impairment (MCI), a condition that causes slight but noticeable memory and thinking problems. The program was designed to be used at home, making it …

This study tested whether a special light treatment could help people with mild cognitive impairment or early Alzheimer's disease. 25 participants who also had sleep problems and lived at home took part. The goal was to see if the light could improve thinking, sleep, and how the …

This study tested whether a special turmeric supplement (MERIVA®) taken for 6 months could improve memory and thinking in 85 older adults (age 60+) with metabolic syndrome. Participants were given either the supplement or a placebo, and their cognitive performance was measured us…

This study tested whether 6 months of weekly Kundalini yoga classes with daily meditation could improve memory and thinking in 81 older adults with mild cognitive impairment, compared to weekly memory training classes with daily homework. The goal was to see if these activities h…

This study tested whether a non-invasive magnetic brain stimulation technique (TMS) can reduce apathy—a severe lack of motivation—in older Veterans with mild memory problems. About 100 participants received either real or sham stimulation over 20 sessions. The goal was to see if …

This study tested if a noninvasive brain stimulation technique called repetitive Transcranial Magnetic Stimulation (rTMS) could improve memory in people with mild cognitive impairment (MCI). 69 participants were randomly assigned to receive active rTMS to one of two brain areas o…

This study tested whether tesamorelin, a drug that increases growth hormone, can improve memory and thinking in people with HIV who have mild cognitive issues. Seventy-three participants took the drug along with a text-messaging app to help them stay on track. The main goal was t…

This study looked at whether an 8-week program of social activities over video calls could improve quality of life and reduce loneliness in older adults, including those with mild memory problems. About 99 people aged 65 and older took part. The results help us understand if simp…

This study tested whether a program that combines talk therapy, brain training exercises, and healthy lifestyle coaching is practical and helpful for people with mild cognitive impairment, traumatic brain injury, multiple sclerosis, or long COVID. Fifteen participants received th…

This study tested whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can improve memory and thinking in older veterans with mild cognitive impairment or dementia. Researchers measured changes in memory tests and blood markers after treatme…

This study looked at whether combining cognitive training (brain exercises) with aerobic training (like walking or cycling) can improve thinking skills and quality of life in older adults with mild cognitive impairment (MCI). 44 participants aged 60 and older with mild memory iss…

This study explored whether music improvisation training can improve self-regulation and brain health in older adults, including those with mild cognitive impairment. Fifty-three participants aged 60 and older with little to no music background took part. The goal was to see if i…

This study tested a new, drug-free approach to help older adults with mild cognitive impairment or early Alzheimer's disease. The treatment combined a gentle electrical current applied to the head (tDCS) with cognitive training and a special light shined up the nose (near infrare…

This study looked at whether music therapy singing sessions can improve memory, language, and quality of life in 100 people with Alzheimer's disease or mild cognitive impairment. Over 12 months, participants worked with a licensed music therapist and were compared to a control gr…

This study tested an experimental drug called SAGE-718 in 174 people with mild memory problems or mild dementia caused by Alzheimer's disease. The main goal was to see if the drug could improve thinking skills, especially processing speed, compared to a placebo. The trial has bee…

This study tested a special sleep therapy program, called Sleep-SMART, for older veterans who have both mild memory problems and trouble sleeping. The program adds memory-support strategies to standard insomnia therapy to help veterans learn and stick with the treatment. Thirty v…

This study tested whether a mix of cognitive training, physical exercise, healthy lifestyle advice, and computer-based activities could help older adults (ages 50-75) with or at risk for mild cognitive impairment. 120 participants were randomly assigned to either the active progr…

This study tested a combination of nutrients (a kit) in 23 adults aged 50-80 to see if it could improve muscle strength, thinking skills, and immune function. Participants took the supplement and were measured on walking distance, leg strength, and cognitive tests. The goal was t…

This study tested a live-streaming group program called Brain Health Together for older adults with mild memory problems. 208 participants joined from home to learn about brain-healthy habits like exercise, social connection, and healthy eating. The goal was to see if the program…

This study tested a new approach to help active-duty service members who had a mild traumatic brain injury (concussion) at least 6 months ago and still struggle with attention and memory. Researchers combined a gentle brain stimulation technique called tDCS with computer-based co…

This study tested whether a digital cognitive behavioral therapy program for insomnia (Sleepio) is practical and helpful for people with mild cognitive impairment or mild dementia who also have sleep problems. Thirty participants were enrolled to see if they would stick with the …

This study tested whether a daily nicotine skin patch could improve memory, thinking, and daily function in people with mild cognitive impairment (MCI). About 348 participants wore either a nicotine patch or a placebo patch for 2 years. The goal was to see if nicotine, known to a…

This study tested a training program for people with mild to moderate Alzheimer's disease. The training used personal photos and videos to recreate familiar situations, aiming to improve orientation to time, place, and person. 126 participants were assigned to either the training…

This study tested a new in-home technology designed to help Spanish-speaking caregivers of people with dementia, Alzheimer's, or mild cognitive impairment. Six caregivers used the system for six months to see if it could lower their stress, anxiety, and loneliness. The goal was t…

This study tested a computer program called SUPERBRAIN DEX designed to improve memory and thinking in people with mild cognitive impairment (MCI), a condition that can be an early sign of Alzheimer's. 140 adults aged 50 to 85 took part. The goal was to see if using the software w…

This study tested whether a non-invasive brain stimulation technique called iTBS rTMS could improve memory in 25 adults with mild cognitive impairment (MCI). The goal was to see if the treatment is practical and if it might help with memory. Participants received either real or f…

This study tested whether wearable devices like Apple Watches could help reduce anxiety, burden, and loneliness in people caring for a family member with dementia or mild cognitive impairment. 63 caregivers in the U.S. used the technology at home for 6 months. The goal was to see…

This study tested a new training program called SEMAT that teaches people with early-stage Alzheimer's or mild cognitive impairment how to use memory aids like calendars and lists. The goal was to help them stay independent in daily life. 68 older adults took part, and researcher…

This study tested a non-invasive electrical stimulation on the skin to see if it could improve long-term memory in people with mild cognitive impairment (MCI). 80 older adults with MCI received either real or fake stimulation while learning word pairs. Their memory was tested rig…

This small study tested a specially designed video game called Hometown Bound to see if it could improve memory and thinking in people with mild cognitive impairment after cancer treatment or an ICU stay. Nine adults played the game three times a week for four weeks. Researchers …

This study tested whether learning to play Go or Chess could improve thinking skills in 80 people with mild cognitive impairment or subjective cognitive decline. Participants were split into groups that played Go, Chess, both, or neither for 12 weeks. The goal was to see if these…

This study looked at whether a daily drink made from perch essence could improve thinking and memory in people with mild cognitive impairment (MCI). Fifty-four adults aged 45 and older with MCI were split into two groups: one drank perch essence twice a day for 24 weeks, and the …

This study tested whether long-term exposure to a special light can improve sleep and memory in 73 people with mild cognitive impairment or early Alzheimer's disease living at home. Participants used the light at home, and researchers measured changes in thinking skills and sleep…

This study looked at whether combining exercise with a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can help improve memory in people with mild cognitive impairment or Alzheimer's disease. Researchers tested 60 adults aged 50 and older …

This study looked at whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory loss or early dementia. Twenty-five participants took either the drug or a placebo for one year. Researchers tracked side effects and measured thinking s…

This study looked at three different online wellness programs to see if they could help improve memory, thinking, and brain function in adults aged 55 and older who were experiencing memory problems. The goal was to find out which program worked best for supporting brain health. …

This study tested if computer-based cognitive fitness activities could improve thinking and depression in 38 older adults who were already taking antidepressants. Participants did brain training exercises, and researchers measured changes in their mental flexibility, memory, and …

This study looked at whether a whey protein called alpha-lactalbumin could improve mood and thinking in healthy older adults, including those with mild memory issues. The protein is thought to help the brain make serotonin, a chemical that affects mood and memory. Researchers gav…

This study tested whether levetiracetam, a medication used for epilepsy, can reduce abnormal brain overactivity and improve memory and thinking in people with early Alzheimer's disease. Fifty-eight participants received the drug or a placebo to see if it calms brain signals and b…

This study tested whether a dietary supplement called citicoline could improve sleep and thinking in 100 older adults with mild cognitive impairment (MCI), a condition that can lead to Alzheimer's disease. Participants took citicoline or a placebo for several months. Researchers …

This study tested a program where a pharmacist works with people with dementia, their caregivers, and their doctor to review and safely stop medications that may no longer be helpful. The goal was to reduce the number of pills taken, making life simpler and safer. The study inclu…

This study looked at whether a specially designed light therapy can improve sleep, thinking, mood, and behavior in people with Alzheimer's disease or mild cognitive impairment. About 100 participants received either the active light or a placebo for 6 months. The goal was to see …

This study tested a non-invasive brain stimulation technique called HD-tDCS in 269 people with mild cognitive impairment or early Alzheimer's. The goal was to see if different doses could improve brain connectivity and memory. Participants received the stimulation while undergoin…

This study looked at whether people with mild cognitive impairment or Alzheimer's dementia can understand and make decisions about receiving their PET scan results, which show protein buildup in the brain. Researchers also checked how patients and their care partners reacted emot…

This study tested a special device that sprays insulin into the nose to see how much gets into the brain. Insulin is a hormone that helps control blood sugar, but it may also affect memory. The study included 20 adults with mild memory problems or normal cognition. Researchers me…

This study looked at how older adults make decisions about where to live and how to get care if they develop memory loss or Alzheimer's disease. Researchers followed 293 participants over time to see if they had made plans for staying at home or moving to a care facility. The goa…

This study looked at whether a program called Patient Priorities Care can work in regular doctor visits for people with dementia or mild cognitive impairment. 178 participants received a packet before their appointment and could talk with a trained helper about their personal car…

This small study tested whether real-time neurofeedback (a type of brain training) could improve memory-related brain activity in older veterans with mild cognitive impairment. Four veterans aged 60 and older participated. The goal was to see if this non-invasive approach could h…

This study looked at whether certain hormone levels in the blood are different in people with Alzheimer's disease, mild memory problems, or normal aging. Researchers measured IGF-I and IGFBP-3 in 693 older adults to see if these levels are linked to thinking and memory. The goal …

This study looked for chemical markers in blood and urine that could help detect Alzheimer's disease early. Researchers compared samples from 95 people with normal aging, mild cognitive impairment, or Alzheimer's. The goal is to develop a simple test that catches the disease befo…

This study looked at whether replacing a narrowed heart valve (TAVR) can improve thinking and memory in 81 adults with mild cognitive impairment. Researchers tested participants with a 5-minute quiz before the procedure and again at 30 days and 6 months after. The goal was to see…

This study tested whether giving insulin through the nose can help people with mild memory problems. Researchers measured how much insulin reached the brain fluid and checked its effect on memory. The study included 13 adults with normal cognition or mild cognitive impairment.

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted care. 26 residents, family members, and staff took part to see if the robot helped with engagement and mood. The goal was to understa…

This study looked at whether text message reminders help people over 55 with normal thinking or mild memory issues follow a daily morning light routine. The light therapy is meant to adjust the body's internal clock. Twenty healthy adults took part, and researchers measured their…

This study checked if a Spanish version of the Frail'BESTest, a test that measures balance and fall risk, works correctly for frail people over 60 who also have mild memory problems. Researchers tested 83 residents in care facilities. The goal was to make sure the tool is reliabl…

This study tested whether specially designed tablet games, called VibrantMinds, can measure and improve cognitive skills in older adults with mild cognitive impairment or dementia. 26 participants aged 65 and older played the games, and researchers tracked changes in thinking, mo…

This study tested whether a personalized computer program that lets seniors with mild cognitive impairment choose their own enjoyable activities can improve their attitudes toward computers and make standard brain training more effective. About 50 older adults from senior living …

This pilot study tested an online educational program called the Brain Health Support Program (BHSP) designed to teach people about dementia and how to lower their risk through lifestyle changes like diet, exercise, and social connection. Twenty adults with mild memory concerns o…

This study tested a program called Keeping on Course for people with mild cognitive impairment (MCI) and their care partners. The goal was to teach communication skills to help them feel more in control while coping with MCI. 29 dyads participated in the program, which was delive…

This study looked at whether a non-drug approach called Strategy Training could slow down disability in older adults with mild cognitive impairment (MCI). Researchers tested 105 participants on daily tasks like shopping and bill paying to see if training helped them need fewer cu…

This study looked at whether a 12-week time-restricted feeding plan (eating only during a set window each day) is practical and acceptable for older adults (ages 65-80) who have mild cognitive impairment and obesity. The goal was to see if people would stick with the diet and to …

This study looked at 150 people with mild memory issues to see if a special MRI scan (pCASL) can give similar information as a standard PET scan. The goal is to find a simpler, cheaper way to detect early brain changes. Participants had MRI, PET, and spinal fluid tests, and were …

This study involved over 6,000 Medicare patients with mild cognitive impairment or dementia. Researchers wanted to see if a special brain scan (amyloid PET) helps doctors make better treatment decisions and improves patient outcomes. The study focused on including people from div…

This study collected brain wave (EEG) data from 29 people at different stages of Alzheimer's disease, from those with no symptoms to severe dementia. Researchers also included people with a related condition called dementia with Lewy bodies. The goal was to see if EEG patterns co…

This pilot study tested a 12-week mobile-health program designed to increase physical activity in people with mild cognitive impairment (MCI) and their caregivers. Sixteen participants with amnestic MCI and their caregivers were enrolled to see if the program was feasible and acc…

This study tested a simple idea: sending gentle reminders (nudges) to doctors and caregivers to help reduce or stop certain high-risk medications in people with dementia. Researchers worked with 250 patients aged 65 and older to see if this approach was practical and could be mea…

This pilot study tested whether remote smartphone tests of thinking, memory, and motor skills can identify older adults who might develop confusion (delirium) after spine surgery. 34 participants completed the tests before surgery. The goal was to see if this approach could help …

This study looked at the gut bacteria of 44 adults aged 50-90, including healthy volunteers, people with mild cognitive impairment, and those with early Alzheimer's disease. Researchers wanted to see if lifestyle changes could alter the gut microbiome and possibly slow memory dec…

This completed study tested whether an AI platform can detect mild cognitive impairment and dementia by analyzing speech. Researchers compared language patterns from 196 older adults (55+) with standard cognitive tests. The goal was to see if speech changes can serve as a screeni…

This study looked at whether a simple home exercise program (the Otago Exercise Program) could reduce fall risk in older adults (65+) who have mild memory problems and recently broke a hip from a fall. About 60 participants were followed for 6 months. The goal was to see if the e…