Nicotine patch trial aims to boost memory in seniors
NCT ID NCT02720445
First seen Nov 01, 2025 · Last updated Jun 21, 2026 · Updated 35 times
Summary
This study tested whether daily nicotine patches could improve memory and daily function in 348 people with mild cognitive impairment (MCI). Participants wore either a nicotine patch (up to 21 mg) or a placebo patch for two years. The goal was to see if nicotine, known to affect brain receptors linked to memory, could help slow or improve thinking problems.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Augusta University Movement and Memory Disorders
Augusta, Georgia, 30912, United States
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Brain Matters Research
Delray Beach, Florida, 33445, United States
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Brain Matters Research
Stuart, Florida, 34997, United States
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Central Arkansas Veterans Healthcare System
North Little Rock, Arkansas, 72205, United States
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Central States Research (formerly Tulsa Clinical Research)
Tulsa, Oklahoma, 74104, United States
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Georgetown University
Washington D.C., District of Columbia, 200072145, United States
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Glenn Biggs Institute at the University of Texas Health
San Antonio, Texas, 78229, United States
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Headlands Eastern MA LLC
Plymouth, Massachusetts, 02360, United States
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Houston Methodist Neurological Institute
Houston, Texas, 77030, United States
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Integrative Clinical Trials
New York, New York, 11229, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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Kingfisher Cooperative, LLC
Spokane, Washington, 99202, United States
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LeHigh Valley Hospital
Allentown, Pennsylvania, 18105, United States
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Miami Jewish Health Systems
Miami, Florida, 33137, United States
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Mount Sinai School of Medicine
New York, New York, 100296552, United States
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Neurology Clinic, P.C.
Cordova, Tennessee, 38018, United States
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New York University Medical Center
New York, New York, 100166055, United States
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Northwestern University
Chicago, Illinois, 606113010, United States
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Nuvance Health Medical Practice Ct, Inc.; Associated Neurologists, PC
Danbury, Connecticut, 06810, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Penn State Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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Perseverance Research Center
Scottsdale, Arizona, 85254, United States
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Providence Brain and Spine Institute
Portland, Oregon, 97225, United States
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Ralph H. Johnson VA Health Care System
Charleston, South Carolina, 294011113, United States
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SUNY Upstate Medical University
Syracuse, New York, 13210, United States
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Sharp Neurocognitive Research Center
San Diego, California, 92123, United States
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Syrentis Clinical Research
Santa Ana, California, 92705, United States
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USC Rancho Los Amigos
Downey, California, 90242, United States
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University at Buffalo (UBMD)
Buffalo, New York, 14203, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Washington Memory and Brain Wellness Center
Seattle, Washington, 98195, United States
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University of Wisconsin
Madison, Wisconsin, 53706, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212, United States
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Velocity Clinical Research - Boise
Meridian, Idaho, 83642, United States
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Velocity Clinical Research - Syracuse
East Syracuse, New York, 13057, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Nicotine transdermal patch
What this could lead to
If it works, this could point toward a treatment that slows memory decline in people with mild cognitive impairment.
What could go wrong
This is a Phase 2 trial with moderate size, so results are not definitive. Nicotine can be addictive and may cause side effects like skin irritation or sleep problems.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.