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Heart valve fix may boost brain power, study says

NCT ID NCT05614986

Knowledge-focused Sponsor: Baylor Research Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 81 people with mild memory problems who were getting a heart valve replacement (TAVR). Researchers tested their thinking and memory with a 5-minute quiz before the procedure and again 30 days and 6 months after. The goal was to see if fixing the heart valve could also improve brain function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

81 people

The number who actually took part.

Started

Jan 2022

Finished

Feb 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing TAVR with mild cognitive impairment

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 years or older 2. Undergoing a TAVR procedure 3. Possible MCI as determined by procedures already used in the TAVR clinics, including 1 of the 4: 1. MMSE \< 27 2. History of MCI, dementia, or stroke (CVA or TIA) 3. History of prescription treatment for MCI 4. Discretion of the investigator, physician, or clinic staff 4. Scores 25 or less on the mini MoCA exam Exclusion Criteria: 1\. In another research study that doesn't allow dual enrolment, or dual enrolment has not been granted.

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aortic stenosis Mild cognitive impairment

Contacts and locations

Locations

  • Baylor Heart and Vascular Hospital

    Dallas, Texas, 75226, United States

  • Baylor Scott & White All Saints at Fort Worth

    Fort Worth, Texas, 76104, United States

  • Baylor Scott & White Medical Center - Temple

    Temple, Texas, 76508, United States

  • Baylor Scott and White The Heart Hospital Baylor Plano

    Plano, Texas, 75029, United States

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