MILD COGNITIVE IMPAIRMENT

This study tests whether senolytic drugs—medicines that clear out aging 'zombie' cells—are safe and workable for people with early Alzheimer's or mild memory problems. About 48 adults aged 60 and older with elevated tau protein will receive either the drug or a placebo. The main …

This study tests whether the sleep medication trazodone can slow down memory decline in people who have both mild cognitive impairment (MCI) and obstructive sleep apnea (OSA). About 134 participants will take either trazodone or a placebo for one year. Researchers will measure ch…

This study looks at whether using hearing aids over the long term can slow down memory loss and reduce the risk of dementia in older adults. It follows 629 people aged 70-84 who already took part in a previous hearing study. Researchers will compare those who got hearing help rig…

This study tests a non-invasive brain stimulation technique to improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. The goal is to strengthen brain connections in the frontal lobe to help people compens…

This study tests whether computerized working memory training can slow the progression of mild cognitive impairment (MCI) to dementia. About 205 adults with MCI will be randomly assigned to one or two training periods or an active control group. Researchers will track memory, dai…

This study tests whether three common diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 adults aged 40 to 75 will take one of the drugs for 48 …

This study tests whether a drug already used for heart disease, nicorandil, can safely help people with a type of brain aging that looks like Alzheimer's but isn't. It includes 64 adults aged 75 and older who have mild memory problems and signs of hippocampal sclerosis. The main …

This study tests whether a device that delivers light and sound stimulation for 60 minutes each day can slow the decline in memory and daily living skills in people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inac…

This study tests whether using ultrasound to temporarily open the blood-brain barrier is safe and feasible for people with mild Alzheimer's or mild cognitive impairment who are already receiving standard antibody therapy. The goal is to see if this approach can help more medicati…

This study uses a safe, painless eye scan (OCT) to see if early Alzheimer's can be detected by measuring how support cells in the retina respond to light. Researchers will compare 100 people with early signs of Alzheimer's to those without any signs. If successful, this could lea…

This study is testing a new way to look at brain scans, called Cortical Disarray Measurement (CDM), to see if it can help doctors better diagnose Alzheimer's disease. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results with st…

This 7-year study tests whether a combination of gentle brain stimulation (tDCS) and computer-based cognitive exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression who are at higher risk. Part…

This study tests whether metformin, a common diabetes medication, can prevent Alzheimer's dementia in people with mild cognitive impairment. About 326 overweight adults aged 55-90 without diabetes will take either metformin or a placebo for 18 months. Researchers will track memor…

This study is testing a home-based program designed to help prevent long-term memory decline in older adults at risk for Alzheimer's disease. The program combines brain-training exercises with a gentle, non-invasive brain stimulation technique called tDCS, which is delivered by a…

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can improve brain energy use and reduce stress in people with mild memory problems or early Alzheimer's. Researchers will measure changes in brain chemistry and thinking skills over ti…

This pilot study tests a 12-month lifestyle program designed to lower stress and improve memory in 45 adults aged 50+ with mild cognitive impairment (MCI). Participants join group and individual activities focused on nutrition, exercise, and brain health. The study checks if the …

This study tests a light therapy that shines a special light on the forehead to see if it can help memory and thinking in people with early Alzheimer's or mild cognitive impairment. About 196 older adults (ages 65-85) will receive either the real light treatment or a fake one for…

This study tests whether taking vitamin D3, folic acid, and vitamin B12 for 6 months can slow memory loss in people aged 50-70 with mild cognitive impairment (MCI). 380 participants will be split into groups getting low or high doses of these vitamins or a placebo. The goal is to…

This study looks at whether giving caffeine to adults aged 70 and older after major surgery can lower their risk of postoperative delirium—a state of sudden confusion. Researchers will compare caffeine to a placebo in 250 participants. The goal is to see if this simple, everyday …

This study looks at whether a 12-month nurse-led support program can improve symptoms and quality of life for people with mild cognitive impairment or dementia living at home, and reduce stress for their caregivers. About 200 participants from Stanford's Alzheimer's Disease Resea…

This study compares two virtual symptom management programs for adults aged 60 and older who have both chronic pain and early signs of memory decline. The goal is to see which program better improves physical function, thinking skills, and emotional well-being. Participants will …

This study tests two types of memory training for people with Parkinson's disease who also have mild memory problems. 120 participants will be randomly assigned to one of two training programs and complete 8 sessions over 8 weeks. The goal is to see if these programs improve thei…

This early-phase study tests whether a mobile app that shares continuous glucose monitor data with a care partner can help older adults (65+) with type 2 diabetes and mild cognitive impairment manage their blood sugar. Fourteen participants and their care partners will use the ap…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can reduce heavy drinking and improve thinking skills in older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Researchers will measure changes in dri…

This pilot study tests whether lamivudine, an HIV medication, can reduce brain-damage markers in people with mild cognitive impairment (MCI) and early Alzheimer's signs. Twenty-three participants will take the drug for 24 weeks. The goal is to see if it lowers certain proteins in…

This study looks at whether a 12-week yoga program can improve brain function and thinking skills in older adults with heart failure and mild memory loss. Researchers will use brain scans, memory tests, and blood samples to measure changes. The goal is to see if yoga is a helpful…

This early-stage study tests whether a combination of two drugs, dasatinib and quercetin, is safe and feasible for people with mild cognitive impairment or Alzheimer's disease. The drugs target senescent ('zombie') cells that accumulate with aging. Twenty participants aged 55 and…

This study tests whether a combination of virtual reality exercises and computer-based brain training can improve memory and thinking in 172 older adults with heart failure who have mild cognitive impairment. Participants will use these tools at home or in clinic, and researchers…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study tests a nature-based program led by caregivers for people with mild cognitive impairment or dementia living at home. About 48 pairs (a person with memory issues and their caregiver) will be randomly assigned to either start the program right away or wait. The program i…

This study tests a computer-based brain-training program for people with mild cognitive impairment (MCI), an early stage of Alzheimer's disease. The training aims to improve working memory by teaching participants to increase certain brain activity. The goal is to see if this app…

This study tests a program that focuses on the strengths of people with mild dementia and their family caregivers, rather than their limitations. The program aims to improve thinking skills and make caregiving feel more manageable. About 272 older adults with mild dementia or mil…

This study tests a tablet app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app in weekly sessions over six weeks, the…

This study looks at whether increasing glutathione, a natural antioxidant in the body, can improve thinking and memory in older adults with mild cognitive impairment. Sixty participants will take either glutathione-boosting supplements or a placebo for 12 weeks, then stop for ano…

This study follows 1,400 people with early-stage Alzheimer's or mild cognitive impairment to track their healthcare costs, resource use, and quality of life over time. It is purely observational and does not test any new treatments. The goal is to better understand the economic a…

This study is testing whether smartphones and wearable devices can detect early signs of Alzheimer's disease better than standard questionnaires. Researchers will follow 3,500 adults, including healthy volunteers and those with mild cognitive impairment or Alzheimer's, to see if …

This study is for adults 18 and older who have a family history of Alzheimer's or early memory concerns. Researchers will measure participants' health, blood markers, and thinking skills every six months to see how personalized care plans might help prevent or treat Alzheimer's. …

This study looks at how a protein called tau builds up in the brain and how it relates to memory loss in older adults with mild cognitive impairment. Researchers will use special PET scans and high-resolution MRI to measure tau buildup and brain thickness. The goal is to better u…

This study uses a special brain scan called DaTSCAN to learn more about aging and diseases like Parkinson's, Alzheimer's, and dementia. Researchers will compare scan results with clinical diagnoses in 500 adults aged 40-90. The goal is to improve understanding and diagnosis of th…

This study from Stanford University uses cameras and sensors placed in the homes of 25 older adults (65+) to automatically track behaviors like mood changes and agitation. The goal is to see if these tools can help doctors detect and monitor early signs of dementia or other menta…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will follow 505 adults aged 50 and older to see how many experience mental fogginess (called postoperative cognitive dysfunction) up to 4.5 months after surgery. The goal …

This study looks at 800 people already enrolled in an Alzheimer's research center. Researchers use a special brain scan to measure amyloid, a protein linked to Alzheimer's. The goal is to see how amyloid builds up over time, which may help find the best time to start treatments i…

This study looks at whether a Mediterranean or Mediterranean-keto diet can improve gut and brain health in older adults living in rural areas, some with mild memory problems. About 61 people aged 55-85 will follow one of these diets for 10 weeks, with follow-ups up to a year. Res…

This study looks at whether older adults with mild memory problems or early Alzheimer's can use a tablet-based brain training app at home. Researchers want to see if the app is easy to use and acceptable to patients. 36 participants will try the app for two weeks and share their …

This study looks at how live music changes brain activity, heart rate, and anxiety in people with early Alzheimer's or mild cognitive impairment, and their caregivers. Researchers will measure brain waves and heart signals while participants listen to live or recorded music. The …

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning their personal Alzheimer's risk from brain scans. It includes 100 Black and White adults with mild cognitive impairment. The goal is to…

This study follows 100 people aged 60–85 over 5 years to see if problems with smell, hearing, or balance speed up memory loss and lower quality of life. Participants will have tests with a neurologist, psychologist, and ear-nose-throat doctor. The goal is to understand which sens…

This study looks at how a type of brain stimulation called theta-burst stimulation (TBS) affects thinking skills in people with mild cognitive impairment (MCI). Researchers will use brain scans and memory tests to see if they can predict who will benefit most. The goal is to bett…

This study looks at whether treating sleep problems can help reduce mood and behavior issues like anxiety, agitation, and irritability in people with early Alzheimer's or mild cognitive impairment. Researchers will give 150 adults either a sleep therapy program (CBT-I) or a contr…

This study will enroll 100,000 adults aged 45 and older to track early signs of Alzheimer's and Parkinson's disease using phone apps, voice recordings, and movement tests. Researchers aim to create better tools for early diagnosis by combining digital data with genetic and biolog…

This study uses a special MRI technique to measure brain stiffness in people with Alzheimer's, mild cognitive impairment, and healthy volunteers. Researchers want to see if brain stiffness can serve as a new marker to detect Alzheimer's disease. The study involves 450 participant…

This study looked at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. About 95 participants with mild memory concerns or at risk for cognitive de…

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…

This long-term study follows 1,500 adults with normal memory, mild cognitive impairment, or Alzheimer's disease. Researchers use brain scans, memory tests, and genetic data to understand how the disease progresses and to improve future clinical trials. The study also aims to incl…