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Virtual brain training shows promise for pain and memory in seniors

NCT ID NCT05373745

Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two virtual, 8-week programs (Active Brains 1 and 2) in 267 older adults with chronic pain and early cognitive decline. Both programs taught skills like relaxation, cognitive training, and positive psychology to help manage symptoms. Researchers measured changes in physical function, step count, and walking ability, and followed participants for 6 months to see if improvements lasted.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
behavioral intervention (Active Brains 1 and Active Brains 2 programs)
What this could lead to
If successful, these programs could offer a practical, non-drug way for older adults to better manage chronic pain and early memory issues at home.
What could go wrong
This is a completed study comparing two behavioral programs, not a test of a new drug or cure. Results may show only modest benefits, and what works in a study may not work for everyone in daily life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

267 people

The number who actually took part.

Started

Jun 2022

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and female outpatients, age 60 years or older * Have nonmalignant chronic pain for more than 3 months * Reports early cognitive decline (subjective or objective) * Telephone Interview for Cognitive Status-30 score greater than or equal to 17 * Functional Activities Questionnaire score less than 9 * Able to perform a 6-minute walk test at an accelerated pace * English fluency/literacy * Willingness and ability to participate and use an ActiGraph watch and smartphone app to view and sync the step count and sleep data * Free of concurrent psychotropic or pain medication for at least 2 weeks prior to initiation of treatment, OR stable on current psychotropic or pain medication for a minimum of 6 weeks and willing to maintain a stable dose * Cleared by a medical doctor for study participation and no self-reported concerns about physical functioning on the revised Physical Activity Readiness Questionnaire (PAR-Q; score 0) Exclusion Criteria: * Diagnosed with dementia or neurodegenerative disease * Diagnosed with medical illness expected to worsen in the next 6 months * Diagnosed with serious untreated mental illness (i.e., schizophrenia) or untreated substance use disorder * Current suicidal ideation reported on self-report * Engaging in regular mindfulness practice \> 45 min/week or has completed a course of cognitive behavioral therapy in the past 3 months * Regular use of a digital-monitoring device * Engagement in regular intensive physical exercise for \>30 minute daily

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Cognitive Dysfunction Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Mild cognitive impairment Older adults Physical activity

Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.