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Brain training may delay dementia in At-Risk seniors

NCT ID NCT04792528

Disease control Sponsor: Sorlandet Hospital HF Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether computerized memory training can slow mental decline in people with mild cognitive impairment (MCI), a stage between normal aging and dementia. About 205 participants from Norwegian memory clinics will do brain exercises on a computer or play a simple game (control group). Researchers will track memory, daily function, and quality of life for up to 4 years to see if training helps delay dementia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
computerized cognitive training (COGMED RM program)
What this could lead to
If it works, this could offer a non-drug way to delay dementia in people with mild cognitive impairment, potentially improving quality of life and reducing healthcare costs.
What could go wrong
This is an early-stage study with 205 participants, so results may not apply to everyone. The training may not slow decline, and benefits could be small or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

205 people

The number who actually took part.

Started

May 2021

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for the REACT MCI study: * Diagnosis of MCI, based on the Mayo/winblad criteria or confirmation of current MCI status within the last 6 months before study enrollment. * The ability to use and accessibility to an iPad or computer. * Fluent in Norwegian. * Spinal tap performed and results available Exclusion Criteria for the REACT MCI study: * Patients unable to undergo a MRI investigation based on claustrophobia or metal foreign bodies are excluded from the study. * Major psychiatric illness and current substance abuse * Recent stroke Inclusion Criteria for the REACT MCI Glymphatics substudy: * Enrollment in the REACT MCI study * Participant allocated to Sorlandet Hospital or Oslo University Hospital Exclusion Criteria for the REACT MCI Glymphatics substudy: * Individuals with known allergy against contrast solutions * Individuals with other serious allergies * Individuals with kidney failure or glomerular filtration rate \< 30 * Individuals younger than 18 or older than 80 * Pregnant or lactating women * For individuals \>70 years or with medications affecting kidney function the glomerular filtration rate needs to be less than week old.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment

Contacts and locations

Locations

  • N.K.S. Kløveråsen

    Bodø, 8076, Norway

  • NKS Olaviken Alderspsykiatriske sykehus - Hukommelsesklinikk

    Bergen, 5009, Norway

  • Oslo Universitetssykehus Ullevål

    Oslo, Norway

  • St. Olavs Hospital

    Trondheim, 7006, Norway

  • Sørlandet Sykehus Arendal

    Arendal, Norway

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