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Zapping the brain to sharpen memory: new trial tests TMS in older adults

NCT ID NCT03574207

Symptom relief Sponsor: University of Nebraska Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in healthy adults and in older adults with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's. Researchers will use face-word association tasks and brain scans to measure changes. The study enrolls 48 participants across three groups: young adults, healthy older adults, and those with aMCI.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial magnetic stimulation (TMS)
What this could lead to
If it works, this could point toward a non-invasive treatment to improve memory in people with mild cognitive impairment.
What could go wrong
This is a small, early pilot study. Results may not generalize, and memory improvements may be modest or not lasting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2019

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The investigators anticipate enrolling 48 subjects total: * 16 healthy young adults (age 19-35) * 16 healthy older adults (demographically matched to aMCI group for age, sex, and educational attainment) * 16 older adults diagnosed with amnestic mild cognitive impairment (aMCI) Inclusion Criteria: 1. Adults 19 years of age and older 2. Healthy adults without history of psychiatric or neurological disease OR previous diagnosis of amnestic MCI 3. Must be able to provide informed consent 4. Must have the ability to comply with basic instructions and have the ability to sit comfortably still for TMS, neuroimaging, and other study procedures. 5. Right-handed based on self-report (pre-screening) and evaluation with a standard test. Exclusion Criteria: 1. Individuals who have ferrous metal implanted in their body (other than in their teeth) or any other non-removable medical and/or metallic implant 2. Individuals who have increased intracranial pressure 3. Individuals who have any major medical illness (e.g., cancer, HIV+, hepatitis, heart disease) 4. Individuals who have confounding/dual diagnoses (e.g., comorbid mental illness and substance use disorder) 5. Individuals with current diagnoses of alcohol or substance abuse/dependence 6. Individuals with epilepsy, any history of seizures, or using medication that lowers seizure threshold 7. Individuals with any neurological disorder other than aMCI (e.g., stroke, traumatic brain injury) 8. Pregnant females --- as determined by urine pregnancy test --- will be excluded from this study due to uncertainty of the effects of MRI and TMS on the fetus 9. Not right-handed based on self-report (pre-screening) or evaluation with a standard test 10. Not a native English speaker.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Memory Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Memory loss Mild cognitive impairment

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Nebraska Medical Center

    RECRUITING

    Omaha, Nebraska, 68198, United States

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