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Could High-Intensity workouts and diet tame chest pain from tiny heart vessels?

NCT ID NCT06681896

Symptom relief Sponsor: Royal United Hospitals Bath NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether a 24-week personalized program called MICROFIT—combining high-intensity interval training with a personal trainer and Mediterranean-style dietary advice—is feasible for people with microvascular coronary dysfunction, a condition where small heart blood vessels don't work properly, causing chest pain. About 40 participants will be randomly assigned to either MICROFIT plus usual care or usual care alone. The study focuses on whether people can stick with the program and whether it shows promise in reducing angina symptoms, as measured by questionnaires and heart tests.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MICROFIT - a 24-week personalized program combining high-intensity interval training (HIIT) with a personal trainer and Mediterranean-style dietary advice
What this could lead to
If this program proves feasible and shows promise, it could lead to a larger trial testing whether exercise and diet can reduce chest pain and improve quality of life in people with microvascular angina.
What could go wrong
This is a small feasibility study, so results may not be conclusive. The exercise program is intense and may be hard for some to stick with, and it's unclear if it will meaningfully reduce symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 * Angina or angina equivalent symptoms * Unobstructed coronary arteries at the time of coronary angiogram. This will be defined as plaque causing \<40% epicardial vessel stenosis or 40-90% with a fractional flow reserve (FFR) ≥0.8 * Evidence of microvascular dysfunction on ICA (CFR \<2.5 and/or AchFR \<1.5) Exclusion Criteria: * New York Heart Association class III/IV heart failure * Severe left ventricular impairment (ejection fraction≤35%) * Severe heart valve disease * Significant cardiomyopathy (as assessed by a cardiologist) * Severe hypertension (defined as blood pressure \>180/120mmHg (despite three anti-hypertensive agents) * Uncontrolled arrhythmia * A history of aortic dissection, recent (\<6 months) acute pulmonary embolus, deep vein thrombosis, stroke or transient ischaemic attack, severe autonomic or peripheral neuropathy, acute systemic illness or fever, severe acute or chronic renal failure, severe pulmonary fibrosis or interstitial lung disease (in line with other trials investigating HIIT exercise) * Pregnancy or breastfeeding (at any point during the study. Patients becoming pregnant during the study will be asked to withdraw due to additional radiation exposure and risks from HIIT) * Physical inability to participate in exercise * Significant claustrophobia or metallic implants which would limit MRI imaging * Intolerance to regadenoson testing (high degree atrioventricular block, severe asthma or airways disease) * Current participation in another intervention-based trial * Inability to fully understand the verbal and written descriptions of the study and instructions provided during the study duration.

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Conditions

The condition(s) this trial relates to.

coronary microvascular disorder Microvascular Angina

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Coronary microvascular dysfunction (CMD) Microvascular angina Microvascular coronary dysfunction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal United Hospitals Bath NHS Foundation Trust

    RECRUITING

    Bath, BA1 3NG, United Kingdom

  • University Hospitals Bristol and Weston NHS Foundation Trust

    RECRUITING

    Bristol, BS2 8ED, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.