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Could a 2-Second longer pause in CPR save more hearts?

NCT ID NCT06824961

Disease control Sponsor: Amsterdam UMC, location VUmc Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests whether extending the compression pause from 3 to 5 seconds during mechanical CPR helps rescuers deliver two effective breaths more often. It includes adults who had a cardiac arrest outside the hospital and were treated with a LUCAS device. The study compares the percentage of pauses where both breaths are given, and also looks at whether the heart restarts and survival with good brain function improves.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Mechanical CPR with a 5-second ventilation pause
What this could lead to
If a longer pause helps, it could improve ventilation and increase the chance of restarting the heart during cardiac arrest, potentially saving more lives.
What could go wrong
The trial is early and results may not show a clear benefit. Longer pauses might reduce blood flow during compressions, and outcomes depend on many factors beyond pause duration.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 692 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥16 years of age) * OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel * LUCAS® 3.1 has been used during the resuscitation attempt Exclusion Criteria: * Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses * Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest (CA)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ambulance Amsterdam

    RECRUITING

    Amsterdam, North Holland, 1075LB, Netherlands

  • Regionale Ambulance Voorziening Kennemerland - Ambulancezorg GGD Kennemerland

    RECRUITING

    Haarlem, North Holland, 2015CK, Netherlands

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