Amsterdam Umc, Location Vumc

This trial tests a computer-assisted reintegration protocol for employees on sick leave due to musculoskeletal disorders, such as back, neck, or shoulder pain. The protocol helps occupational health professionals follow national guidelines and Dutch law when guiding employees bac…

This study looks at whether irreversible electroporation (IRE) can safely and effectively treat recurrent pelvic tumors in people who cannot have surgery, radiation, or other local treatments. IRE uses electrical pulses to destroy cancer cells without cutting or heating tissue. R…

This trial is investigating whether giving a combination of chemotherapy and immunotherapy before surgery, and continuing immunotherapy after, can improve outcomes for people with a rare and aggressive type of bile duct cancer. Participants will be randomly assigned to receive ei…

This trial tests whether extending the compression pause from 3 to 5 seconds during mechanical CPR helps rescuers deliver two effective breaths more often. It includes adults who had a cardiac arrest outside the hospital and were treated with a LUCAS device. The study compares th…

This trial tests whether an accelerated, precisely targeted brain-stimulation protocol can outperform the standard approach for people with treatment-resistant depression. Participants receive either the new accelerated intermittent theta burst stimulation (iTBS) or the standard …

This study tests whether a single, high dose of radiation given before repeat breast-conserving surgery is safe and effective for women whose breast cancer has returned after previous treatment. The trial will enroll 25 women aged 50 or older with small, low-risk tumors. The goal…

This trial investigates whether a single, high dose of MRI-guided radiation given before surgery can completely eliminate low-risk breast cancer. Women aged 50 and older with small, early-stage tumors receive one radiation dose, then wait 6 to 12 months before surgery to see if t…

This study is testing a new approach for people with pancreatic cancer that can be surgically removed. Before surgery, patients receive a combination of chemotherapy (mFOLFIRINOX), an immunotherapy drug (pembrolizumab), and targeted radiation (SABR). After surgery, they continue …

This study looks at whether using a temporary mechanical heart pump during a high-risk heart procedure (PCI) can improve safety and outcomes. About 98 adults with weak hearts and complex blockages will be randomly assigned to receive the pump or standard care. The goal is to see …

This study tests whether the drug sotatercept can improve right heart function in people with pulmonary arterial hypertension (PAH). PAH causes high blood pressure in the lungs, straining the right side of the heart. Sotatercept targets the underlying blood vessel changes, not ju…

This study tests whether a special PET scan tracer, [18F]F-AraG, can visualize activated T-cells in tumors and healthy tissue of patients with advanced non-small cell lung cancer. The goal is to see if changes in tracer uptake during anti-PD-1 immunotherapy can predict how well t…

This trial is testing two experimental PET imaging tracers to see if they can show T cell activity in lung cancer tumors. People with non-small cell lung cancer who are about to have surgery after standard chemo-immunotherapy will receive two PET scans. The scans will be compared…

This study tests a wearable device called Cue2Walk that automatically detects freezing of gait in people with Parkinson's disease and provides rhythmic cues to help them keep walking. The study will compare the device's effectiveness and cost against usual care in 84 participants…

This study tests a non-invasive brain stimulation technique called TMS for adults with obsessive-compulsive disorder (OCD) who did not improve enough with standard exposure therapy. 250 participants will receive either real or sham TMS combined with therapy for 5-7 weeks. The goa…

This study tests whether a 12-week functional power training program (MegaPower) helps children with cerebral palsy achieve their personal participation and activity goals better than usual care. The trial will include 66 children aged 4-12 who can walk with or without help. Rese…

This study tests a gentle brain stimulation technique called rTMS to see if it can reduce severe fatigue and concentration problems in people with long COVID. Researchers will give 66 adults either real or fake (placebo) stimulation over six weeks. The goal is to find a safe, non…

This trial tests five different dialysis approaches in people with end-stage kidney disease to see how each affects salt stored in tissues and the health of small blood vessels. Participants receive each method in random order over four weeks. Researchers use MRI scans and skin p…

This study follows 500 breast cancer patients whose cancer has returned in the same area (locoregional recurrence). They receive standard care: re-irradiation with or without hyperthermia (heat therapy). The goal is to track side effects, quality of life, and survival over five y…

This observational study aims to find early biomarkers that can predict if a person's lung scarring (pulmonary fibrosis) will get worse quickly. Researchers will follow 450 adults with various types of interstitial lung disease, including IPF and other fibrotic conditions. Partic…

This study, called YoPA, is testing whether getting teenagers directly involved in designing changes to their neighborhoods can help them be more active, sleep better, and spend less time on screens. Researchers in Denmark, the Netherlands, Nigeria, and South Africa will work wit…