Amsterdam Umc, Location Vumc

This study looks at whether using a temporary mechanical heart pump during high-risk angioplasty (a procedure to open blocked heart arteries) improves safety for people with weak hearts. About 98 adults with severe coronary artery disease and reduced heart function will be enroll…

This study tests whether sotatercept, a new drug that targets the root cause of blood vessel scarring in the lungs, can improve right heart function in people with pulmonary arterial hypertension (PAH). About 20 adults with moderate to severe PAH will receive injections every thr…

This study tests a new treatment for women with a return of breast cancer after prior lumpectomy and radiation. Instead of standard radiation after surgery, patients receive a single, high-dose radiation session directly to the tumor before surgery. The goal is to shrink the tumo…

This study is testing a new approach for people with pancreatic cancer that can be removed with surgery. Before surgery, patients receive a combination of chemotherapy, immunotherapy, and targeted radiation. After surgery, they continue with chemotherapy and immunotherapy. The go…

This study tests if a non-invasive brain stimulation technique called TMS can reduce OCD symptoms in people who didn't improve with standard exposure therapy. 250 adults will receive either real or fake TMS alongside their regular therapy for 5-7 weeks. Researchers will track sym…

This study tests a device called Cue2Walk that automatically detects when people with Parkinson's disease freeze while walking and provides rhythmic cues to help them keep moving. The goal is to see if it improves quality of life and reduces freezing compared to usual care. About…

This study tests a gentle brain stimulation method called rTMS to see if it can reduce severe fatigue and concentration problems in adults with long COVID. 66 participants will receive either real or placebo rTMS over six weeks. The goal is to improve energy and thinking by targe…

This study tests whether a 12-week functional power training program helps children with cerebral palsy (ages 4-12) achieve their personal activity goals, like walking or playing with peers. About 66 children will either receive the training or continue their usual care. The goal…

This study brings together teenagers (ages 12-18) from disadvantaged areas in Denmark, the Netherlands, Nigeria, and South Africa with researchers and local leaders. Over three years, the teens will help design and test changes to their neighborhoods—like parks and streets—to mak…

This study follows 500 breast cancer patients whose cancer has returned in the same area. They will receive additional radiation therapy, some with and some without hyperthermia (heat treatment). The goal is to compare side effects, quality of life, and cancer control over five y…

This observational study aims to find early warning signs (biomarkers) that can predict when lung scarring (fibrosis) will get worse in people with various interstitial lung diseases. Researchers will follow 450 adults with conditions like idiopathic pulmonary fibrosis (IPF) or o…