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Could chilling the body after cardiac arrest save more brains?

NCT ID NCT06776549

Disease control Sponsor: Kagawa University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Participants are randomly assigned to either hypothermia or normothermia, and the study tracks survival, neurological outcomes, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temperature control (hypothermia at 33-34°C versus normothermia)
What this could lead to
If cooling improves outcomes, it could become a standard way to protect the brain and boost survival after cardiac arrest requiring ECMO.
What could go wrong
The trial is still testing this approach, and cooling may not improve outcomes or could carry risks like infection or bleeding. Results are not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 468 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * OHCA * Age of 18-75 years, known or estimated * An initial cardiac arrest rhythm of ventricular fibrillation/pulseless ventricular tachycardia or pulseless electrical activity Exclusion Criteria: * ECMO initiated after sustained return of spontaneous circulation (ROSC) and patients with sustained ROSC before ECMO initiation * OHCA of presumed non-cardiac etiology * Time from emergency call or witnessed arrest to hospital arrival of \>60 min * Time from hospital arrival to ECMO initiation of \>60 min * Pre-hospital ECPR * Unavailability of the ECMO heat exchanger for temperature control * Glasgow Coma Scale score before temperature control of \>8 * Core body temperature upon hospital arrival of ≤32ºC * Surgical intervention before temperature control (e.g., surgical intervention for the primary disease or complications related to resuscitation/ECMO procedures) * Do Not Attempt Resuscitation) order confirmed prior to temperature control * Limitations in intensive care before temperature control * Known cerebral performance category (CPC) of 3-4 before cardiac arrest * Known chronic obstructive pulmonary disease with home oxygen therapy * Known or suspected pregnancy * Concomitant illness, such as malignancy, shortens life expectancy (180-day survival unlikely) * Consent not obtained or withdrawn by the participant or surrogate * Other reasons, physician's decision not to enroll the patient

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Conditions

The condition(s) this trial relates to.

cardiac arrest Out-of-Hospital Cardiac Arrest post-cardiac arrest syndrome sudden cardiac arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ecmo treatment Out-of-hospital cardiac arrest (OHCA) Post-cardiac arrest syndrome Temperature

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    29 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Asahikawa Medical University Hospital

    NOT_YET_RECRUITING

    Asahikawa, Hokkaido, 0788510, Japan

  • Ebina General Hospital

    RECRUITING

    Ebina, Kanagawa, 2430432, Japan

  • Hitachi General Hospital

    RECRUITING

    Hitachi-shi, Ibaraki, 317-0077, Japan

  • Hokkaido University Hospital

    RECRUITING

    Sapporo, Hokkaido, 0608648, Japan

  • Hyogo Emergency Medical Center

    RECRUITING

    Kobe, Hyōgo, 6510073, Japan

  • Hyogo Prefectural Kakogawa Medical Center

    RECRUITING

    Kakogawa, Hyōgo, 6758555, Japan

  • Institute of Science Tokyo Hospital

    RECRUITING

    Tokyo, 1138519, Japan

  • Japanese Red Cross Musashino Hospital

    RECRUITING

    Tokyo, 1808610, Japan

  • Kagawa University Hospital

    RECRUITING

    Kita-gun, Kagawa-ken, 7610793, Japan

  • Keio University Hospital

    RECRUITING

    Tokyo, 1608582, Japan

  • Kurume University Hospital

    RECRUITING

    Kurume, Fukuoka, 8300011, Japan

  • Kyoto Second Red Cross Hospital

    NOT_YET_RECRUITING

    Kyoto, Kyoto, 6028026, Japan

  • National Hospital Organization Disaster Medical Center

    RECRUITING

    Tokyo, 1900014, Japan

  • Nippon Medical School Hospital

    RECRUITING

    Tokyo, 1138603, Japan

  • Okayama University Hospital

    RECRUITING

    Okayama, Okayama-ken, 7008558, Japan

  • Okinawa Prefectural Nanbu Medical Center & Children's Medical Center

    RECRUITING

    Shimajiri-gun, Okinawa, 9011193, Japan

  • Osaka Saiseikai Senri Hospital

    RECRUITING

    Suita, Osaka, 5650862, Japan

  • Oshima Prefectural Hospital

    RECRUITING

    Amami, Kagoshima-ken, 8940015, Japan

  • Saiseikai Yokohamashi Tobu Hospital

    RECRUITING

    Yokohama, Kanagawa, 2308765, Japan

  • Saitama Red Cross Hospital

    RECRUITING

    Saitama, Saitama, 3308553, Japan

  • Sapporo Medical University Hospital

    RECRUITING

    Sapporo, Hokkaido, 0608556, Japan

  • Sendai Medical Center

    RECRUITING

    Sendai, Miyagi, 9838520, Japan

  • St. Luke's International Hospital

    RECRUITING

    Tokyo, 1048560, Japan

  • Tohoku University Hospital

    RECRUITING

    Sendai, Miyagi, 9808574, Japan

  • Tokyo Metropolitan Bokutoh Hospital

    RECRUITING

    Tokyo, 1308575, Japan

  • Tokyo Metropolitan Tama Medical Center

    RECRUITING

    Tokyo, 1838524, Japan

  • Tottori Prefectural Central Hospital

    RECRUITING

    Tottori-shi, Tottori, 6800901, Japan

  • Toyooka Public Hospital

    RECRUITING

    Toyooka, Hyōgo, 6688501, Japan

  • Tsuyama Chuo Hospital

    RECRUITING

    Tsuyama, Okayama-ken, 7080841, Japan

More trials for these conditions

Other studies related to the condition(s) this trial covers.