Can targeted temperature control boost brain recovery after cardiac arrest?
NCT ID NCT07762144
First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This study follows 500 people who survived a cardiac arrest to understand post-cardiac arrest syndrome (PCAS), a complex condition that often leads to death or brain damage. Researchers will compare different temperature management strategies and other treatments to see which might improve survival and neurological outcomes. They will also develop a model to predict a patient's chances of a good recovery, helping doctors guide families in making care decisions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Targeted temperature management strategies and other interventions for post-cardiac arrest care
- What this could lead to
- If successful, this research could identify better ways to manage temperature and other treatments after cardiac arrest, potentially improving survival and neurological recovery, and lead to a tool to predict patient outcomes.
- What could go wrong
- This is an observational cohort study, so it cannot prove cause and effect. The findings may not apply to all patients, and the effectiveness of any specific intervention will need confirmation in future trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2014
- Expected to finish
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Dec 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This study will enroll all eligible patients presenting to the emergency departments of the six centers who satisfy the following inclusion and exclusion criteria
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients who have achieved return of spontaneous circulation (ROSC) after cardiac arrest; 2. With accessible intravenous or intraosseous vascular access; 3. Clinical manifestations meeting any one of the following criteria: presenting with post-resuscitation brain injury, post-resuscitation cardiac dysfunction, manifestations of systemic ischemia-reperfusion injury, or other ongoing deteriorating pathological changes. Exclusion Criteria: 1. Patients who have not achieved return of spontaneous circulation (ROSC) after cardiac arrest; 2. Patients who have declined cardiopulmonary resuscitation (CPR) (or whose legally authorized representative has refused CPR).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Emergency Dept of Peking University Third Hospital
Beijing, Beijing Municipality, 100191, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a forehead sensor save brains after cardiac arrest?
- Beyond survival: what shapes life after cardiac arrest?
- Can head position and cooling boost brain recovery after cardiac arrest?
- Could chilling the body after cardiac arrest save more brains?
- Could a 'robotic cough' stop deadly pneumonia in ICU patients?
- Updated cardiac arrest guidelines may boost survival, study hints